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Interesting Studies: Probably low carb related in one way or another

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  • AlabasterVerveAlabasterVerve Posts: 3,157Member Member Posts: 3,157Member Member
    Re: New Evaluation of Isoflavone Exposure in the French Population

    Levels of phytoestrogen from #soy now reaching worrying levels in the French population.
    Expected to lengthen menstrual cycles, acts as endocrine-disruptors, & display toxic effects on reproduction & on mammary and pituitary carcinoma.

    Source
    | Via

    Related:
    Removing isoflavones from modern soyfood: Why and how? Source | Via
    Dear men: There’s no evidence that eating Impossible Whoppers will give you breasts Media
  • AlabasterVerveAlabasterVerve Posts: 3,157Member Member Posts: 3,157Member Member
    Re: Katz, Willett, and Hu disgrace themselves once again

    Backlash Over Meat Dietary Recommendations Raises Questions About Corporate Ties to Nutrition Scientists

    The True Health Initiative (THI) is a nonprofit founded and headed by David Katz, MD. The group’s website describes its work as “fighting fake facts and combating false doubts to create a world free of preventable diseases, using the time-honored, evidence-based, fundamentals of lifestyle and medicine.” Walter Willett, MD, DrPH, and Frank Hu, MD, PhD, Harvard nutrition researchers who are among the top names in their field, serve on the THI council of directors.

    Katz, Willett, and Hu took the rare step of contacting Laine about retracting the studies prior to their publication, she recalled in an interview with JAMA. Perhaps that’s not surprising. “Some of the researchers have built their careers on nutrition epidemiology,” Laine said. “I can understand it’s upsetting when the limitations of your work are uncovered and discussed in the open.”

    Subsequent news coverage criticized the methodology used in the meat papers and raised the specter that some of the authors had financial ties to the beef industry, representing previously undisclosed conflicts of interest.

    But what has for the most part been overlooked is that Katz and THI and many of its council members have numerous industry ties themselves. The difference is that their ties are primarily with companies and organizations that stand to profit if people eat less red meat and a more plant-based diet. Unlike the beef industry, these entities are surrounded by an aura of health and wellness, although that isn’t necessarily evidence-based.


    Full Article

    Related: Siephan Guyenet cuts ties with the group

    "I was very disappointed to read this article describing attempts by the True Health Initiative to suppress the series of meta-analyses on red meat that was recently published in Annals of Internal Medicine. As a result of this, I've cut my ties with THI.

    This isn't about whose opinions on red meat are right or wrong. It's about the integrity of the scientific method. I hope THI can find a better path forward."
    -Stephan Guyenet, PhD
    Reference:
    Eat Less Red Meat, Scientists Said. Now Some Believe That Was Bad Advice.

    On Monday, in a remarkable turnabout, an international collaboration of researchers produced a series of analyses concluding that the advice, a bedrock of almost all dietary guidelines, is not backed by good scientific evidence. NY Times

    Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations (NutriRECS) Consortium

    Methods: The recommendations were developed by using the Nutritional Recommendations (NutriRECS) guideline development process, which includes rigorous systematic review methodology, and GRADE methods to rate the certainty of evidence for each outcome and to move from evidence to recommendations. A panel of 14 members, including 3 community members, from 7 countries voted on the final recommendations. Strict criteria limited the conflicts of interest among panel members. Considerations of environmental impact or animal welfare did not bear on the recommendations. Four systematic reviews addressed the health effects associated with red meat and processed meat consumption, and 1 systematic review addressed people's health-related values and preferences regarding meat consumption.

    Recommendations: The panel suggests that adults continue current unprocessed red meat consumption (weak recommendation, low-certainty evidence). Similarly, the panel suggests adults continue current processed meat consumption (weak recommendation, low-certainty evidence).

    Primary Funding Source: None.


    Source | Critique by Cristopher Gardner (vegetarian, researcher).

    More media:
    No Need To Cut Back On Red Meat? Controversial New 'Guidelines' Lead To Outrage NPR
    Is red meat back on the menu? BBC

  • AlabasterVerveAlabasterVerve Posts: 3,157Member Member Posts: 3,157Member Member
    Don't drink sugar.

    Fructose and hepatic insulin resistance

    In this review, we present the data invoking fructose intake with development of hepatic insulin resistance in human studies and discuss the pathways by which fructose impairs hepatic insulin action in experimental animal models. First, we described well-characterized pathways by which fructose metabolism indirectly leads to hepatic insulin resistance. These include unequivocal effects of fructose to promote de novo lipogenesis (DNL), impair fatty acid oxidation (FAO), induce endoplasmic reticulum (ER) stress and trigger hepatic inflammation.

    In summary, dietary fructose intake strongly promotes hepatic insulin resistance via complex interplay of several metabolic pathways, at least some of which are independent of increased weight gain and caloric intake. The current evidence shows that the fructose, but not glucose, component of dietary sugar drives metabolic complications and contradicts the notion that fructose is merely a source of palatable calories that leads to increased weight gain and insulin resistance.


    Full Review | Via
  • AlabasterVerveAlabasterVerve Posts: 3,157Member Member Posts: 3,157Member Member
    This is becoming a thing. Here's another study with improved kidney function.

    Very Low-Calorie Ketogenic Diet: A Safe and Effective Tool for Weight Loss in Patients With Obesity and Mild Kidney Failure.

    A prospective observational real-life study was conducted on ninety-two patients following a VLCKD for approximately 3 months. Thirty-eight had mild kidney failure and fifty-four had no renal condition and were therefore designated as control. Anthropometric parameters, bioelectrical impedance and biochemistry data were collected before and at the end of the dietary intervention. The average weight loss was nearly 20% of initial weight, with a significant reduction in fat mass. We report an improvement of metabolic parameters and no clinically relevant variation regarding liver and kidney function. Upon stratification based on kidney function, no differences in the efficacy and safety outcomes were found. Interestingly, 27.7% of patients with mild renal failure reported normalization of glomerular filtrate after dietary intervention.

    Source
  • AlabasterVerveAlabasterVerve Posts: 3,157Member Member Posts: 3,157Member Member
    Pretty sure there's been some association with increased mortality and salt restriction so this tweet caught my eye. "Salt restriction worsened death and #heartfailure rehospitalization in HF patients @pacificheart by Dr. Richard Wright."

    Supporting science is thin at best right now I think--IDK? Some links in the thread if anyone is curious.
  • AlabasterVerveAlabasterVerve Posts: 3,157Member Member Posts: 3,157Member Member
    Inuit metabolism revisited: what drove the selective sweep of CPT1a L479?

    Recent hypotheses predict that this variant may have been selected in response to possible detrimental effects of chronic ketosis in communities with very low carbohydrate consumption. Assessing these hypotheses alongside several alternative explanations of the selective sweep, this analytical review challenges the notion that the selection of L479 is linked to predicted detrimental effects of ketosis.

    Source | Via

    Related:
    edited February 12
  • AlabasterVerveAlabasterVerve Posts: 3,157Member Member Posts: 3,157Member Member
    Baby-formula sales are slumping, so the companies that make it have turned to supplements for 3-year-olds.

    as infant-formula sales have slumped in recent years, baby-formula companies are starting to see toddler milk as their next move as well.

    Toddler milk is the fastest-growing category of breast-milk substitutes, according to the World Health Organization, and is now available at grocery stores and on websites such as Amazon. But child-nutrition experts say this type of milk is expensive, unnecessary, and possibly even unhealthy. Although toddler milk can cost four times the price of cow’s milk, the drink consists mainly of powdered milk, corn syrup, and vegetable oil.


    Re: US toddler milk sales and associations with marketing practices

    Media | Source | Via
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