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Gut Microbiome impact on Health and Fitness
Replies
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NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
The procedure reduces the symptoms that are currently recognized as part of the autism diagnosis - speech issues, behavioral issues, social issues. It doesn't change a person's ability to create or imagine, it merely helps with the barriers that a lot of people with autism face. Many of the "famous ASD individuals" who we hear about also became famous from something they worked on individually or with a close friend or colleague, not as part of a larger organization, because the symptoms can make it difficult to get hired or keep a job in an environment that is built around neurotypical behavior being acceptable and expected.
I'm not sure how a procedure that could reduce the symptoms and allow the creative part of flourish more effectively would reduce our progress in any area.
Nonsense. These things are too interconnected. We don't (yet) have the ability to be as precise and selective as you're describing. If we did, no treatment would have side effects ever.
And autism doesn't work the way you seem to think it does.12 -
GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.15 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.
Neither do some autistic people. My daughter will never be independent, marry, or do many of the things most people do. She can't even have a conversation. We would both be thrilled for there to be a treatment.
Absolutely, I too know some highly functional people on the spectrum who are fantastic and their characteristics make them who they are and proud of it. They should not have any treatment foisted on them. But, there's a large swath of people who are quite disabled an in desperate need of help.
ETA: That doesn't mean I hold high hopes in any of the info in this thread. Just was interested in what you were trying to say here.20 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.
Neither do some autistic people. My daughter will never be independent, marry, or do many of the things most people do. She can't even have a conversation. We would both be thrilled for there to be a treatment.
Absolutely, I too know some highly functional people on the spectrum who are fantastic and their characteristics make them who they are and proud of it. They should not have any treatment foisted on them. But, there's a large swath of people who are quite disabled an in desperate need of help.
ETA: That doesn't mean I hold high hopes in any of the info in this thread. Just was interested in what you were trying to say here.
There's a saying, "if you know one autistic person ... you know one autistic person." Not all alike at all.
I'm sorry to hear about the effect it's had on your daughter's life. I hope she finds a lot of happiness in her day to day life.
🤗7 -
NorthCascades wrote: »NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.
Neither do some autistic people. My daughter will never be independent, marry, or do many of the things most people do. She can't even have a conversation. We would both be thrilled for there to be a treatment.
Absolutely, I too know some highly functional people on the spectrum who are fantastic and their characteristics make them who they are and proud of it. They should not have any treatment foisted on them. But, there's a large swath of people who are quite disabled an in desperate need of help.
ETA: That doesn't mean I hold high hopes in any of the info in this thread. Just was interested in what you were trying to say here.
There's a saying, "if you know one autistic person ... you know one autistic person." Not all alike at all.
I'm sorry to hear about the effect it's had on your daughter's life. I hope she finds a lot of happiness in her day to day life.
🤗
Thanks. Every day is an adventure!5 -
While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
"Some drugs work well for one person but are ineffective for another; some also produce adverse events for certain individuals but not others. A study, using human gut bacteria and a mouse model, investigates whether our gut bacteria might help explain why."
"Scientists are now investigating gut bacteria's role in a diverse range of diseases, from Parkinson's disease to anxiety to heart disease.
Once an obscure niche of medical research, gut bacteria are now firmly in the spotlight."
"There are many reasons why people respond differently to the same drug, including age, sex, and diet. So, could the bacteria in our gut also be playing a role?
According to the latest team of researchers to look into this question, our microbiome contains 150 times more genes than our own genome. These microscopic tenants produce a wide array of enzymes, some of which can alter drugs, either activating them or rendering them ineffective."
"To investigate the interaction further, the scientists used gnotobiotic mice — animals free from microbes.
They found that 176 out of the 271 drugs (64.9%) could be metabolized by gut bacteria, reducing the drug's concentration significantly. They also showed that each strain of bacteria could metabolize 11–95 types of drug."
"In the future, it might be possible to modify a person's microbiome to ensure that a drug works effectively and reduce the risk of serious adverse events. However, scientists will need to carry out much more research to build up a clearer picture of how these interactions work.
For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy. Nevertheless, the findings from this latest study make it seem likely that our gut bacteria are having at least some influence on the medicines we take."14 -
GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php11 -
GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
What do you call this reference the writer cited in the article by a hyperlink?
https://nature.com/articles/s41586-019-1291-3
9 -
NorthCascades wrote: »NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
You're asking me how a prediction I made about a possible future is factual? Really?
For the record, Bill Gates is an Aspie. The guy who invented the concept of bit torrents is an Aspie, too; he had an insight about how data moves through the cloud based on how bees swam, and basically dropped everything until he saw his idea through. At Microsoft we have a team whose job it is to hire autistic devs and testers, because it's good business. The "interview" lasts two weeks, it's set up like a coding camp, applicants get to play with all kinds of cool technology and talk about what they like and what they can imagine.
But, sure, sticking other people's poop inside humans sounds like a great future too.
The procedure reduces the symptoms that are currently recognized as part of the autism diagnosis - speech issues, behavioral issues, social issues. It doesn't change a person's ability to create or imagine, it merely helps with the barriers that a lot of people with autism face. Many of the "famous ASD individuals" who we hear about also became famous from something they worked on individually or with a close friend or colleague, not as part of a larger organization, because the symptoms can make it difficult to get hired or keep a job in an environment that is built around neurotypical behavior being acceptable and expected.
I'm not sure how a procedure that could reduce the symptoms and allow the creative part of flourish more effectively would reduce our progress in any area.
Nonsense. These things are too interconnected. We don't (yet) have the ability to be as precise and selective as you're describing. If we did, no treatment would have side effects ever.
And autism doesn't work the way you seem to think it does.
I have a child with autism.4 -
GaleHawkins wrote: »GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
What do you call this reference the writer cited in the article by a hyperlink?
https://nature.com/articles/s41586-019-1291-3
Do you know what a references section is? From the nature of your reply it doesn't appear that you do because your reply is totally off the mark. It would be like someone asking, "do you know what a grocery list is" and you replying the word "cucumber". Except even then, "cucumber" could be on a grocery list, whereas I doubt simply listing a URL is an appropriate way to cite something in any commonly used citation standard (ex. APA).
edit: But to answer your question - I call that not a references section. I call it a link to an article.12 -
GaleHawkins wrote: »For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy.
Pay close attention to the bolded sentence. This point has been made repeatedly yet you continue to ignore it
10 -
NorthCascades wrote: »GaleHawkins wrote: »NorthCascades wrote: »GaleHawkins wrote: »Autism symptoms reduced nearly 50 percent two years after fecal transplant
There goes nearly half our progress in software and science.
How do you think that is factual?
Do you not think all of the scientists working to make life better autistic children and their parents are doing a noble work? My hat is off to all of them where they strike out, get on base or make a homerun.
While there are some gains being made in understanding the prenatal prevention of autism by addressing future mothers gut microbiome health it will be decades before this effort goes mainstream if it becomes a proven solution in some cases. Millions of new cases of autism are in the pipeline to address post birth as best as possible.
We have known for 1000's years eating the right foods is a key factor of total health and mental well being. Now science is proving it in their research labs as we type. Cancer, Arthritis, Autism, etc diseases are starting to point back to the gut microbiome more and more that often can be fixed with the right kinds of food on the market today without spending any new money perhaps. Not sure about the medical complex but I bet health insurance carriers will be happy to hear this news. I know new parents will be excited with any pre or post birth autism solutions.
[Pause for your daily run on sentence] Well given that one of the reasons why people won't vaccinate their children is because a scientist and former doctor (Andrew Wakefield) falsely claimed that vaccines cause autism and, despite his "findings" summarily debunked, parents still won't vaccinate their children even if there is a measles outbreak, no - I don't think that all scientists and parents who working to make life better for autistic children (and adults) are doing noble work.
Neither do actual autistic people. Does what they want matter or should they shut up and accept everyone's help?
Many find the idea of a cure to be insulting. Autism isn't like a cold, it's a fundamental part of who people are. The Aspies I know are all great people with fantastic novel ways of seeing the world.
I wasn't planning to respond to these comments, but it's continued to bother me how you are taking the autism experiences you personally are familiar with, which sadly represent only a small segment of the ASD community, and making broad generalizations based on that. That's wonderful you have the opportunity to work with so many talented and capable autistic people. But not many are savants, possess the ability to "see in pictures", or have an all-consuming special interest that benefits society. Are you familiar at all with the statistics on unemployment and underemployment among those with ASD, including those considered high-functioning and who may be highly educated? With how many adults that still live at home and require the support of aging parents? Do you realize that many, if not most, struggle with comorbid conditions like anxiety, depression, and OCD? I wouldn't blame you if you didn't, because until very recently, I had no reason to know these things either. Believe me, I struggle with the question of where my son's personality ends and his struggles begin, and I realize it's a subject of debate among some, but as with everything, I would hope that people would seek to become better informed and be open to learning from others' experiences before forming an opinion.
Sorry for the derail.16 -
johnslater461 wrote: »GaleHawkins wrote: »For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy.
Pay close attention to the bolded sentence. This point has been made repeatedly yet you continue to ignore it
John exactly what point are you trying to make/debate in your above post?6 -
GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
"Some drugs work well for one person but are ineffective for another; some also produce adverse events for certain individuals but not others. A study, using human gut bacteria and a mouse model, investigates whether our gut bacteria might help explain why."
"Scientists are now investigating gut bacteria's role in a diverse range of diseases, from Parkinson's disease to anxiety to heart disease.
Once an obscure niche of medical research, gut bacteria are now firmly in the spotlight."
"There are many reasons why people respond differently to the same drug, including age, sex, and diet. So, could the bacteria in our gut also be playing a role?
According to the latest team of researchers to look into this question, our microbiome contains 150 times more genes than our own genome. These microscopic tenants produce a wide array of enzymes, some of which can alter drugs, either activating them or rendering them ineffective."
"To investigate the interaction further, the scientists used gnotobiotic mice — animals free from microbes.
They found that 176 out of the 271 drugs (64.9%) could be metabolized by gut bacteria, reducing the drug's concentration significantly. They also showed that each strain of bacteria could metabolize 11–95 types of drug."
"In the future, it might be possible to modify a person's microbiome to ensure that a drug works effectively and reduce the risk of serious adverse events. However, scientists will need to carry out much more research to build up a clearer picture of how these interactions work.
For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy. Nevertheless, the findings from this latest study make it seem likely that our gut bacteria are having at least some influence on the medicines we take."
There are a number of factors influencing pharamcokinetic activity - genetics, age, race, but gut bacteria? Unless the bacteria in question is utilizing the active pharmaceutical ingredient there is no provable influence.
This is like trying to change the earth climate by feeding lions broccoli or monitoring butterfly generated turbulence.10 -
GaleHawkins wrote: »While this article is general in nature it does show the impact of one's gut microbiome impact Rx meds can greatly vary from person to person.
Gut bacteria may help explain why drugs don't work for everyone
https://medicalnewstoday.com/articles/325366.php
"Some drugs work well for one person but are ineffective for another; some also produce adverse events for certain individuals but not others. A study, using human gut bacteria and a mouse model, investigates whether our gut bacteria might help explain why."
"Scientists are now investigating gut bacteria's role in a diverse range of diseases, from Parkinson's disease to anxiety to heart disease.
Once an obscure niche of medical research, gut bacteria are now firmly in the spotlight."
"There are many reasons why people respond differently to the same drug, including age, sex, and diet. So, could the bacteria in our gut also be playing a role?
According to the latest team of researchers to look into this question, our microbiome contains 150 times more genes than our own genome. These microscopic tenants produce a wide array of enzymes, some of which can alter drugs, either activating them or rendering them ineffective."
"To investigate the interaction further, the scientists used gnotobiotic mice — animals free from microbes.
They found that 176 out of the 271 drugs (64.9%) could be metabolized by gut bacteria, reducing the drug's concentration significantly. They also showed that each strain of bacteria could metabolize 11–95 types of drug."
"In the future, it might be possible to modify a person's microbiome to ensure that a drug works effectively and reduce the risk of serious adverse events. However, scientists will need to carry out much more research to build up a clearer picture of how these interactions work.
For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy. Nevertheless, the findings from this latest study make it seem likely that our gut bacteria are having at least some influence on the medicines we take."
There are a number of factors influencing pharamcokinetic activity - genetics, age, race, but gut bacteria? Unless the bacteria in question is utilizing the active pharmaceutical ingredient there is no provable influence.
This is like trying to change the earth climate by feeding lions broccoli or monitoring butterfly generated turbulence.
Would have to agree with this; there is no data/evidence in any package insert I've ever read regarding gut bacteria in the pharmacokinetics section...age, creatinine clearance/renal function, Liver functions/liver substrates, race/genetics, fluid status/electrolytes, hell even gender - all valid parameters that can affect drug kinetics and dynamics (not gut flora).5 -
GaleHawkins wrote: »
In Australia, Fecal Microbiota Transplantation (FMT) was initially developed by Borody. At his Centre for Digestive Diseases in Sydney, Borody has overseen more than 18,000 FMTs for various disorders since 1987. He pioneered in Australia the use of FMT for colitis and Clostridium difficile infection...
Okay, kind of unrelated to anything but just to give credit where credit is due. Borody did not initially develop FMT, or at least not conceptually. He introduced the practice to the western world in its current form, but FMT is among some* of the slowly growing body of interesting, and successful, techniques/medicines that researchers looking at ancient texts, manuscripts, and folk practices have discovered recently. (These types of treatments often seem to involve success that depends on interactions between the body and bacteria, fungus, or substances that modern practices sterilize or otherwise alter in ways that eliminate whatever components made them successful).
FMT was basically practiced in ancient china. The entire concept is still known and practiced, in a variety of forms, in various parts of Asia, although the practice has been dying out. (seriously - check out poop wine. *shudder* - https://www.vice.com/en_us/article/7b7zmg/how-to-make-faeces-wine )
Not saying anything about autism or how the gut might or might not impact anything, but it does get a bit irritating to see non-western, or non-modern, medicinal practices that were derided for years suddenly claimed, polished up, and presented as though they are brand new ideas, you know?
*Another successful ancient remedy rediscovered was a recreation of a 1,000 year old Anglo-Saxon treatment for eye infections that turns out to kill about 90% of MRSA bacteria. (https://www.bbc.com/news/uk-england-nottinghamshire-32117815 )11 -
GaleHawkins wrote: »
In Australia, Fecal Microbiota Transplantation (FMT) was initially developed by Borody. At his Centre for Digestive Diseases in Sydney, Borody has overseen more than 18,000 FMTs for various disorders since 1987. He pioneered in Australia the use of FMT for colitis and Clostridium difficile infection...
Okay, kind of unrelated to anything but just to give credit where credit is due. Borody did not initially develop FMT, or at least not conceptually. He introduced the practice to the western world in its current form, but FMT is among some* of the slowly growing body of interesting, and successful, techniques/medicines that researchers looking at ancient texts, manuscripts, and folk practices have discovered recently. (These types of treatments often seem to involve success that depends on interactions between the body and bacteria, fungus, or substances that modern practices sterilize or otherwise alter in ways that eliminate whatever components made them successful).
FMT was basically practiced in ancient china. The entire concept is still known and practiced, in a variety of forms, in various parts of Asia, although the practice has been dying out. (seriously - check out poop wine. *shudder* - https://www.vice.com/en_us/article/7b7zmg/how-to-make-faeces-wine )
Not saying anything about autism or how the gut might or might not impact anything, but it does get a bit irritating to see non-western, or non-modern, medicinal practices that were derided for years suddenly claimed, polished up, and presented as though they are brand new ideas, you know?
*Another successful ancient remedy rediscovered was a recreation of a 1,000 year old Anglo-Saxon treatment for eye infections that turns out to kill about 90% of MRSA bacteria. (https://www.bbc.com/news/uk-england-nottinghamshire-32117815 )
@shaumom that is very interesting. There is the expression, There is nothing new under the sun.
It's very exciting about FMT broad potential with many diseases.
Thanks for sharing.6 -
I ran across the subject of CBD oil (cannabidiol) and autism late this evening and said what gives here? Well this is stuff our own body makes I learned. Having only had to deal with autism in a highly functional case it challenged my very being and healthcare training so I have no idea what some of you parents, friends and families have faced or are facing. I am tired and will just link to few links tonight and yes some links have agendas but tidbits of info to drill down on. Tomorrow is going to be a long day but if there are thoughts please post them and we can drill down on some of the new research that you want to post that is coming out as well as anecdotal accounts from parents and others. In my 68 years I have never been more interested in or hopeful about than learning about the gut microbiome and how in hindsight I now understand it may explain my major health gains over the past 5 years.
https://hellomd.com/health-wellness/5b3566f9bf4c4d000a0e751d/how-cannabis-can-keep-you-healthy-via-your-gut-microbiome
https://medicalxpress.com/news/2019-01-medical-cannabis-relieves-symptoms-children.html
https://kcci.com/article/iowa-6-year-old-shows-how-access-to-cbd-has-changed-her-life/27823036
https://healthline.com/health-news/parents-using-cbd-to-treat-kids-with-autism
11 -
johnslater461 wrote: »GaleHawkins wrote: »For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy.
Pay close attention to the bolded sentence. This point has been made repeatedly yet you continue to ignore it
Why do you say I repeatedly ignore my own post? Do you not agree with the text above that you quoted that I copied and pasted along with the source?9 -
GaleHawkins wrote: »johnslater461 wrote: »GaleHawkins wrote: »For now, our understanding of the influence of gut bacteria and drug metabolism is still in its infancy.
Pay close attention to the bolded sentence. This point has been made repeatedly yet you continue to ignore it
Why do you say I repeatedly ignore my own post? Do you not agree with the text above that you quoted that I copied and pasted along with the source?
You are either ignoring the bolded sentence, or you don't understand it.
Because anyone who reads and understands the phrase "our understanding is in its infancy" wouldn't be flooding the forums with posts attributing everything to gut bacteria.13
This discussion has been closed.
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