wabmester Member

Yeah, different cuts have different levels of purines. No idea what's in your ground beef, but organ meat has higher levels than other parts. Dried cherries wouldn't be my first choice as a cure since fructose has also been implicated in gout.

I would love to see a study that asked that question! It looks like the body reaches some sort of steady-state after 4 weeks. What perturbs that state? "Fat adaptation" is probably part of it, but I've never seen a good description of what that adaptation is. Personally, I think we're mostly seeing the kidneys adapt. In…

Those ammonium cations are also thought to be sodium-sparing. My understanding is that they couple with excreted ketone anions. That's why people lose so much water and sodium in the first week of going low-carb.

Here's a nice graph from Owen (who worked with Cahill) on nitrogen losses in urine. It doesn't cover hour-by-hour, but it's still instructive. This patient lost 100g protein after 1 day of fasting, and that leveled off to 25g/d after 4 weeks. 100g is close to a quarter-pounder. :)

I think the 20lbs mentioned by Moore was all tissue, no water. DEXA only looks at tissue (via low-powered x-rays). ketosis is muscle sparing Context is important. Ketosis is muscle sparing compared to the alternative during starvation. If the brain continued to need 130g/d of glucose during starvation, and glycerol…

Jimmy Moore is writing a book with Fung called "Fasting Clarity." As part of his research for the book, he did a 30-day fast "coached" by Fung. He did a DEXA scan before and after. He lost 20lbs. According to the DEXA, 10lbs of the 20lbs came from muscle. 10lb muscle loss in 30 days would be 1/3 lb per day, so even more…

It's a trickier balance with exercise. I was almost always ketogenic after a run, even at around 100g carbs. I'd burn around 500 kcal on a run. Maybe half or more from glucose. So that'd be equivalent to burning 60-80g carbs in about 30 minutes.

V, here's a link that doesn't require a login. PDF available, too. http://onlinelibrary.wiley.com/doi/10.1111/apt.13248/full

Yes, it's sticky -- I think she nailed it! My dog's been eating medicinal herbs. :)

It stopped being about weight loss for me a LONG time ago. How do you feel? How are your hunger and cravings compared to your previous diet? Not everybody will lose weight on low-carb, especially those who already have decent insulin sensitivity.

Isn't that the same reason we eat carbs? Cannabinoid receptors. :) She'll eat grass from the lawn, but she does have a preference. Whenever she finds it, she takes a bite of this stuff. No idea what it is.... BTW, did you know that dogs influence our microbiome? Everytime we pet them, there's a bacterial transfer. :)

I see my carnivorous dog eating grass every chance she gets. And the combination of epidemiological studies + mechanistic studies gives me plenty of reasons to hedge my bets with fiber. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention First, dietary fiber resists digestion in the small…

I think the key is to find what naturally reduces appetite for you. You know the problems with intentional calorie restriction: your body tends to adapt by reducing expenditure, and you tend to rebound later and potentially overcompensate. Kind of like trying to restrict sleep.

Two choices: accept it or experiment. Suggested experiments (give them several weeks): 1) Reduce carb intake. Works for some people. 2) Increase nutritional density. I.e., focus on quality rather than quantity of your carb intake. 3) Intermittent fasting. Nothing crazy -- 16:8 is basically just skipping breakfast. This…

Ha! I happily accepted the role of "the guy with the crazy diet." Then my friends started saying stuff like "my blood pressure is kind of high, do you think it'd help me?" This is the book I recommended to my doctor: The Art and Science of Low Carb There are other recommendations in the launch pad, but that's the bible IMO.

Indeed. They're also my favorite snack (and now I have to fight my wife for them since she went LC).

The first step for me was to simply stop logging and to eat to satisfy hunger. Not much has changed in terms of what I eat or even quantities. Yogurt (full-fat, of course) is the only conscious addition -- just to ensure a bit more calcium than I was getting.

Your body doesn't work on percentages. Grams matter. If you eat too much protein, it probably will get converted to glucose, but it's a pretty slow process and not likely to be a problem for weight loss. Also, the older we get, the more protein we need (because we don't synthesize muscle as well as we used to).

I did exactly that. Targeted 100g/d carbs and found myself in ketosis pretty often for a few reasons: 1) exercise 2) some days or weeks my carbs would drop much lower 3) unintentional intermittent fasting, due to lack of hunger I'm not sure there's any advantage, but I liked the flexibility, and I figured our ancestors did…

Depends on your goals for IF. Valter Longo thinks suppressing IGF-1 is important, for example, if your goal is to reduce cancer risk. Protein impacts IGF-1. Fat maybe less so. For info on partial oxidation of fats, here's the Wikipedia entry on ketogenesis: https://en.wikipedia.org/wiki/Ketogenesis Fatty acids are…

I'm sure you know this, but ketosis and fat metabolism are two different things (ketosis is partial oxidation of fat). Anyway, just about any meal will affect insulin levels. But ZC is pretty close to fasting.

I used to break off a bit of 100%-cocoa chocolate bar and sweeten it up a bit by dipping it in peanut butter. Not bad. But then my wife decided to make peanut butter cups: melt the chocolate, add coconut oil to the peanut butter and melted chocolate, pour into little paper cups, freeze to harden the cups. <3 <3 <3

If you're sedentary, you don't need that much protein. Focus on the carbs, but rule of thumb is about 1g per kg of body weight for protein, and no need to hit a fat target -- just use it to reach satiety. Let your body fat meet your fat requirement. :)

Were you trying to use an emoji? I think somebody discovered they cut off messages when posting from a phone.

There was an agenda, and both sides have responded publicly. Hall wanted to "disprove" Taubes' carb-insulin theory of obesity. Taubes responded "what about hunger?" Taubes concedes low fat can work, but he points to Keys' Minnesota starvation experiments to show the consequences. Low fat makes you crazy. :smile:

Kevin Hall does the best studies. Here's a fixed link for the one you're talking about: Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity I have no qualms with the study, but it misses the major difference between low-fat and low-carb: HUNGER.

As Phinney mentioned, the protein losses are the greatest in the beginning and then they taper off after several days. He also mentioned an unpublished study that I would love to see. Basically, Cahill put multiple catheters in his patients and monitored both venous and arterial metabolites as well as waste products.…

I don't think it was necessarily an implication of his diet. I just thought it was cool that Phinney had such a close association with the guy. Stefansson apparently had multiple strokes, starting in his early 70's. His autopsy apparently found signs of brain aneurysms, but his arteries were clear.

Pretty sure he's referring to the classic study "Starvation in Man" by Cahill. There's no question that fasting is catabolic if you believe that study, and it was beautifully done.

Ah, something I know nothing about. :) Still, it's fascinating how several different hormones regulate fluid and sodium levels. Including estrogen: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849969/