I JUST went through this. (following post somewhat gross) I ended up with a blister with three separate blood pockets on my heel. I am finally healed to the point where I can wear my running shoes and not have it all taped up and its 1.5 weeks since using a sterile needle to release the blood and pus.

THe first thing was that, when I originally used the needle, I missed that there was more to this blister than I had thought. I didn't realize that it had gotten so outta hand and there were more than one pockets in there and just did the middle area. So, make sure you don't have that issue. Make the hole horizontal so that you poke two holes, which allows for better flow out and kept it from refilling and dried it out faster.

I got my main relief from finally releasing all the liquids from in there but leaving the outer skin (just made small holes); i let that skin dry for a couple days and then removed it and the skin under it then dried as well.

I left it open as often as possible when not in a shoe to dry out. I did get residual blood and whatnot for a couple days. Whenever I wore shoes or had on my karate pants (long pants that touched the area), I covered it with a simple bandaid.

When running, I put a bandaid on it and then taped it with duct tape. I started at the heel and tapes towards the toes and then I went from the bottom of the foot up like a stirrup.

I now use engo patches in my shoes.