You can always try it.

I have a friend who only did it once a week and she still progressed (at least while she was new to it), though slowly.
Personally I find it a lot harder when I miss one of the 3 days. I tend to fail at the lifts more when I only do 2 sessions a week.

There may be a point where your lifts cap out, and it might come sooner if you're doing it 2 days a week instead of 3.

Maybe you could supplement with some at home calisthenics on Saturdays.

I've only recently had 2 days per week most weeks to dedicate and have definitely had a harder time advancing in weight when I only do 2 days instead of 3. I am getting in a decent workout but not feeling as though I am progressing the same as when I had a steady 3-day pace. However, it's better than not doing it at all I suppose!

You might also consider your timing since if you're going two days during the work week (like M & W) it potentially leaves more of a gap between your workouts on the weekend. Some other stucture may be more beneficial but it depends on what works for you and how not-sore you need to be subsequent days.

It's not bad, you just won't see the same rate of progression. .

yeah, shaming is for jerks. even at 51, i was told by my gp that muscle loss sets in within 'as little as' a week. my gp is funny that way every time i see her it seems like she has a different urgency that's on her mind. i went to ask her about idk, a bursitis thing or something one time, and she offered me a tetanus shot.

anyway, my point here is, she thought that a week was a really short time. i thought 'hey, it's not as urgent as they make out then!' and she was talking about a situation where i thought i had messed up my knee, so her context was one of near-immobility - not even 'just not doing my workouts right now'.

so if it takes someone my age an entire week of sitting around with my foot up on the couch to even start losing muscle mass to the regular processes . . . then i don't think you're going to suffer too much from letting three or four days go by between workouts, instead of two or three. it is true that i'm older than you probably are, but fwiw the couple of times when i did just go in twice a week, i actually felt like i was stronger for it because i'd had that much longer to rest.

I travel for work a lot these days, and so just due to ease of facilitation, running has been my go to. When I am home I am lifting regularly, but sometimes I am only home on weekends, and sometimes not even that much. And even at the once a week-ish level, I am progressing, if ever so slowly. Realistically depends on your goals and how quick you want to get to them.