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Just an additional bit of information; if you live in a higher altitude area (one or more miles up) you may be prone to polycythemia, which is an over production of red blood cells. Taking high amounts of B12 or biotin will unmask the symptoms of polycythemia. Some of the symptoms include; headaches, nausea, itchy skin and…
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B12 has an effect on red blood cells. If you live in a high altitude area (albuquerque, Santa Fe, Denver...) you may have a reaction.