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I use the liquid Splenda, and normally get the generic version of it. The liquid version doesn't use maltodextrin, which may cause a spike in insulin. I've been doing low carb for over 2 years and I use the liquid Splenda for my coffee, tea, and any low-carb desserts, and have lowered my A1C from 5.8 to 5.1.
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I found that Splenda was giving me a headache. I was using it in my coffee or tea, on cereal, my fruits and just overdosing on it, using a dozen packets a day or more. I only cut that out and my headaches went away.