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If you cut your maintenance calories by 500 calories a day and exercise 500 calories a day you should average a loss of two pounds a week. This is doable over the long term. Nutrition and sensible exercise are really the only choice for good health, that's just the way our bodies work.
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Moses from season 11 of The Biggest Loser is a trainer at my gym. He said the women on the show were eating about 800 calories a day and exercising 8-9 hours a day. Thus the huge losses per week. Definitely a "don't try this at home" warning applies.
