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I read so many posts about the opinion Depo does not cause weight gain...I have to say I don't agree. I started Depo 5 months ago, first of all I had a period for 4 of those 5 months, I have gained 30 pounds. I have ALWAYS been thin, 120 - 125 pounds all my life - Im 40 now. No matter how I exercised or ate Ive always…