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To address some of the comments: 1) Vitamin C has nothing to do with this issue as someone above stated. It is furanocoumarins that are causing the inhibition of CYP3A4. It is found in grapefruit and sour (Seville) oranges. It is NOT an issue related to all citrus fruits. 2) The components of BC pills are not the only…
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The components of combination oral contraceptives are metabolized by the CYP450 enzyme system, specifically CYP3A4. Grapefruit juice is a CYP3A4 inhibitor, thus consumption of grapefruit or grapefruit juice will INCREASE exposure to these hormones. The danger in this combination is not reduced efficacy, but increased risk…
