Ketosis/Ketoacidosis, extra info to share....

Options
cramernh
cramernh Posts: 3,335 Member
edited December 2014 in Social Groups
I was informed one of our patients was admitted to the Emergency Room a couple days ago, unresponsive (syncope).

Patient is female, borderline type 2* (followed up below) and was diagnosed with Diabetic Ketoacidosis (DKA). They declared this diagnosis when they ran her urinetest and it wasnt even dark purple, it was black. They immediately drew blood work, multiple panels, ran tests, etc. She was immediately admitted and they were required to start Insulin, Normal Saline and hourly monitoring.

Her husband brought in her food diary (she kept a notebook on her intake) and what they saw was extremely horrible. She was running so low on her carb intake, she was basically netting 10g of carbs - most days. Other days she was actually doing a ketogenic diet - a diet that was never recommended for this patient to begin with. Her caloric intake was well below 900 calories on a regular daily basis.

When she stabilized by hour-four, the Endo, her Primary Care Physician and now a Nephrologist came in to talk with her about the situation.

She damn near had kidney failure - the kidneys were significantly fatigued. Her body produced no insulin, and she did not have enough hydration to get rid of the excess ketones in her body, via urine output due to her choice of an extremely low carb/ketogenic intake, thus causing ketoacidosis.

She was counseled that the minimum requirements of healthy carbohydrates is to help the body encourage insulin to be excreted and utilized at more appropriate times, thus helping to restore insulin sensitivity. She was also advised that ketosis requires careful monitoring, in fact, the Endo advised they were getting her out of ketosis immediately because of the near-breakdown of her kidneys. She was also told, because her weakened kidneys now need to heal, she will need to have her carbs gradually upped every two days to get back into homeostasis (normalization of body function). With exercising, she was told that for at least a month, there would be no rigorous exercise - they arranged for her to work in the cardiac rehab unit so she could use the treadmill and be monitored to help maintain her heart rate/bp.

This woman almost died...... 8-(

*Folks - this patient represents 5% of the entire population as a Type 2 Diabetic situation. Ketoacidosis is more common with Type 1 Diabetics... if it occurs in a Type 2 patient, we are talking serious trouble.

If you follow a Keto diet - do not go this alone. Discuss this with an Endocrinologist who will work in conjunction with your Primary Care Physician. This is never a diet to be done without the medical advisement of your doctor(s).

If you follow Atkins (updated versions), and the first Phase isnt working, there are reasons why it is not working. Discuss with an Endocrinologist what might be more appropriate for you. Even if you are not a diabetic, discuss this topic with an Endo as they are familiar with at least determining the amount of healthy carbs a patient should consider based on BMR calculations, etc.

If you are a patient who has been diagnosed as 'Borderline Diabetic' - take this message seriously: do not go extreme with a low-carb intake. You do run the risk of serious health problems manifesting from making poor choices.

Do not ever go below the 1200 (net or full) calorie mark . If you are well below, you must be under a physician/specialist's care for that. Otherwise, you will definitely cause more problems. If you have been given a caloric restriction, whether 1400, 1600, 1800, TDEE-15%, there is a reason why the treating physician is using that guideline with your care.

If an RD ever tries to trump the advice of a medical physician, inform your physician right away.

Ketoacidosis is not just something that can happen to Type 1 or Type 2 Diabetics either.. this can happen with any patient.

Please make sure, for those that run ketostick-checks, do not ever let it go extremely dark....ever that is a serious medical issue that can develop, or is already happening.....


Thanks....


CramerNH
Moderator
Low Carber Daily Forum
«1

Replies

  • skinnyeascolady
    skinnyeascolady Posts: 287 Member
    Options
    I have to agree with you. I did atkins before and got sick. I do low carb but it is way higher and I work out to make the difference. I do a low carb diet (life style) because it is the only way my body will lose the weight or let the weight go. I am glad you posted this because people don't realize you can overdo any good thing. The atkins diet says for two weeks super low but 20-30 and then increase after the two weeks. Obviously this woman over did a good thing. We need to be accountable and discusing it with your doctor is number one.
  • cramernh
    cramernh Posts: 3,335 Member
    Options
    The atkins diet says for two weeks super low but 20-30 and then increase after the two weeks. Obviously this woman over did a good thing. We need to be accountable and discusing it with your doctor is number one.

    This woman was following the no-carbs version of Atkins according to her husband... but realistically, it was a combination of ketogenic and the first old-school version of Atkins...

    What sucks is that the Endo treating her gave her a very specific guideline to follow, advised her of a list (in writing) of foods to avoid, but also provided her Calorieking.com's Nutritional data book for when she travels, and advised her also to use MFP for tracking, and Calorieking.com online for free nutritional data. She was on a very similar restriction like me but, an 1800cal restriction, have a healthy carb before all workouts, and eat back some (but not all) of the exercise calories. Her carb restriction was 140g per day. Per review of her food diary, she barely took in anything at all.

    (To emphasize this:) Her average daily caloric intake was 900 (rounded) calories. Its a damn miracle this woman is alive. The Endo was quite angry that this patient (or any patient) would willingly consume below the 1200 calorie mark - bad enough she didnt follow her advice on 1800!

    I wont even begin to say what the Nephrologist said... it wasnt good....

    (To emphasize this:) Sad part is the woman hadnt lost any weight either.... cortisol levels through the roof, kidneys on a revolt and also quitting... ughhhhhhhhhhhhhhhhhhhhhh

    I know the Endocrinologist... I not only work in Healthcare and she sees some of my patients, but she is also MY Endocrinologist. Both her and I must have emailed back and forth several times over this case...

    I was compelled to share some of the information to serve the purpose of not only a PSA, but more like a reality check.... crappola can happen... and I will tell you right now: that crappola can happen to any of us if we dont make smart choices about this....
  • TheVimFuego
    TheVimFuego Posts: 2,412 Member
    Options
    A very real example of where people can take a concept too far ... All carbs bad, calories also bad so minimise both ... Not a good idea on any level, including sustainable weight loss.

    Stay healthy out there everyone, food is not to be feared :)
  • skinnyeascolady
    skinnyeascolady Posts: 287 Member
    Options
    good point DeadVim that could well have been the case.That she became in fear of food. I have heard of many cases where that happens. Maybe she thought she could get her weight off faster? Wow glad you shard this info. We need to make informed choices this is a weight loss jurney not a race. Glad she is alive.
  • cramernh
    cramernh Posts: 3,335 Member
    Options
    good point DeadVim that could well have been the case.That she became in fear of food. I have heard of many cases where that happens. Maybe she thought she could get her weight off faster? Wow glad you shard this info. We need to make informed choices this is a weight loss jurney not a race. Glad she is alive.

    From what intake information was taken, she willingly made the choice to take in only the 10g, no more. She relied mostly on information from both Ketogenic and the old-school Atkins plan.

    She made the decision against her Endo's wishes, without consulting with her first.

    She had been bouncing between a 3-5lb loss, and then a regain of the same. Her kidneys (and more than probable), her Liver, and now her brain, could not function on what she was doing.

    When the kidneys fart out, so does the body's ability to regulate electrolytes and hydration.... the urine output she had for the first urinalysis, wasnt a whole hell of a lot, but enough to show the ketostick totally black...

    Unfortunately, a patient like this may never tell the full truth because of the sheer embarassment of 'being caught', when you think about it. It was bad enough she deceived the Endo, but now it was evident, it was so much more.
  • Timehope
    Timehope Posts: 44 Member
    Options
    If she was taking in so few carbs (not to mention so few calories) she could not have been eating any vegetables at all, nor berries, nor nuts, nor tomatoes. Many vitamin pills have some fillers; she may have refused to have those as well. Essentially she was starving -- no wonder cortisol was through the roof. I feel for her: she was probably trying to fight her near-diabetic condition with an extreme effort to stop any production of insulin from her pancreas.

    You are completely right -- attempting an overnight cure for a lifetime condition is certain folly, especially without medical observation. The "cure" is not necessarily wrong but extreme hurry almost certainly is. Thanks for the warning! I hope she recovers.
  • cramernh
    cramernh Posts: 3,335 Member
    Options
    You are completely right -- attempting an overnight cure for a lifetime condition is certain folly, especially without medical observation. The "cure" is not necessarily wrong but extreme hurry almost certainly is. Thanks for the warning! I hope she recovers.

    This was no attempt at an overnight cure. She had been doing this for almost two months...
  • kvalmera
    kvalmera Posts: 129 Member
    Options
    Thanks for the heads up. We had a patient (a 27 yr old male) admitted last night for the same thing. I had actually talked to my husband when I got home about up'ing my carbs. My doctor suggests 20% but I had always kept it lower but I think I will knock it up to 20%. I guess seeing him last night, your email today is kind of a sign.....

    Thank you so much!
  • mstorvik
    mstorvik Posts: 356 Member
    Options
    I have been netting below 30 usually for four months... My eyes dried out, womanly issues are getting worse... etc. I just ate a load of carbs for a few days and lo and behold! Most of the issues cleared up! (But I also feel like crap!) It's no joke that you have to up those carbs... Sometimes it's so hard when you're so scared of them!
  • Casedata
    Casedata Posts: 6 Member
    Options
    Hello, new to this group. I try to average around 120gms a day. Is there ever a chance of hitting ketosis with that amount?
  • roro73
    roro73 Posts: 153 Member
    Options
    bump...good info just need time to read it. Thanks for sharing!
  • debk3p2
    debk3p2 Posts: 82 Member
    Options
    I have been netting below 30 usually for four months... My eyes dried out, womanly issues are getting worse... etc. I just ate a load of carbs for a few days and lo and behold! Most of the issues cleared up! (But I also feel like crap!) It's no joke that you have to up those carbs... Sometimes it's so hard when you're so scared of them!


    I'm going through the same thing - especially with the dry eyes. I've had to up my carbs quite a bit - I'm eating between 70 and 80 a day - around 60 net. I'm still losing weight though and at about the same rate as before. I'm definitely hungrier though. Higher carbs really affect my appetite.
  • mstorvik
    mstorvik Posts: 356 Member
    Options
    I have been netting below 30 usually for four months... My eyes dried out, womanly issues are getting worse... etc. I just ate a load of carbs for a few days and lo and behold! Most of the issues cleared up! (But I also feel like crap!) It's no joke that you have to up those carbs... Sometimes it's so hard when you're so scared of them!


    I'm going through the same thing - especially with the dry eyes. I've had to up my carbs quite a bit - I'm eating between 70 and 80 a day - around 60 net. I'm still losing weight though and at about the same rate as before. I'm definitely hungrier though. Higher carbs really affect my appetite.

    Finally! Someone else who has the same issue! Did you find it hard to up the carbs? I tend to love nuts and peanut butter... I don't like fruit (never really have that much) - what kinds of foods did you add in?
  • StarLeopard
    StarLeopard Posts: 80 Member
    Options
    Just a reminder that there is a huge difference between ketosis and ketoacidosis. I only mention it because some folks still confuse the two
  • PHATFOBIA
    Options
    Hi,
    To what extent did this happen because she was diabetic? That is, whilst I understand any kind of extreme is probably bad for anyone, in a person without diabetes am I right in thinking it would not have come to this type of emergency situation even at negligible carb intake?
    Thanks.
  • cramernh
    cramernh Posts: 3,335 Member
    Options
    Hi,
    To what extent did this happen because she was diabetic? That is, whilst I understand any kind of extreme is probably bad for anyone, in a person without diabetes am I right in thinking it would not have come to this type of emergency situation even at negligible carb intake?
    Thanks.

    She is a prediabetic (Type 2)... as I posted earlier, she presented to the ER from having a syncopal episode... a full workup was performed while the husband was updating the clinical team.

    You are not right in thinking - it took coming from the pt's husband, that she was hardly hitting 10g of carbohydrates.. there were too many days where it was just extreme doses of proteins and moderate fat....

    This can happen to anyone ...even without the prediabetic status (abnormally high A1c).... which is why I posted this incident here as a reminder to everyone in our group that this can happen. Negligible amounts is dangerous in the long term picture. This patient willingly did this to herself and against the Endocrinologist's advice.... and as a result of her extremely poor choices, she was hospitalized.
  • debk3p2
    debk3p2 Posts: 82 Member
    Options
    Finally! Someone else who has the same issue! Did you find it hard to up the carbs? I tend to love nuts and peanut butter... I don't like fruit (never really have that much) - what kinds of foods did you add in?


    For the most part I added sweet potato, white rice, rice crackers and even a tiny bit of oatmeal. I didn't add more fruit in because the safe starch guy (Paul Jaminet) said the issue is caused by low glucose, not low fructose). It is a struggle. Yesterday I was a little under in carbs (40 net) and my eyes are killing me again this morning.

    I wonder if the problem is exacerbated by long term low carbing (at least for people who have that issue). I've been low carb for almost a year now and didn't start having any problems until about two months ago.
  • PHATFOBIA
    Options
    How can that be right when ketogenic and zero to very low carb diets have been around for ages and used quite successfully?

    A syncopal episode is just fainting, right? Like losing consciousness because blood pressure got too low? Why would a lack of dietary carbohydrate ever cause that in someone with no blood sugar issues? Assuming of course that they were getting sufficient fat protein and other nutrients. Sounds like it was the lack of care in keeping up those other things rather than the carbohydrate restriction itself. Protein-sparing modified-fasts also involve almost zero carbohydrate yet are safe because all of the other things are factored in like keeping up fluids and supplementing sodium, potassium, magnesium etc..

    It doesn't sound accurate to blame the whole emergency situation simply on the restriction of carbohydrates.
  • LowcarbNY
    LowcarbNY Posts: 546 Member
    Options
    It doesn't sound accurate to blame the whole emergency situation simply on the restriction of carbohydrates.

    I'm following your line of though also PhatFobia. But pinning down the absolute root cause can be difficult.
    Of course, we are hearing this all 3rd hand and Cramernh was much closer to the situation.
    I'm guessing that dehydration played a key role in this event also.
    Ketosis increases urine output in an attempt to shed excess ketones
    Patient diet was also reported as
    it took coming from the pt's husband, that she was hardly hitting 10g of carbohydrates.. there were too many days where it was just extreme doses of proteins and moderate fat....
    Metabolizing protein also creates more waste products that need to be diluted and excreted. Without adequate hydration, the subject could have rapidly become dehydrated, urine output stops, toxins rise and things get out of control rapidly.
    So blame it on the zero carbs, or blame it on the dehydration, or low calories or all combined but it happened. (typed while drinking my 3rd half liter of water)
    Maybe all of these factors were necessary. Maybe only one (pick your villain ) . I won't argue with cramernh as she was closest to the action and has tons more experience to boot.
  • cramernh
    cramernh Posts: 3,335 Member
    Options
    Side note: Ketogenic Diets original main function in its earliest days, was a medical treatment for refractory epilepsy under strong medical advisement and supervision. It continues to this day, to still be used in the medical community for those patients. Anyone outside of that equation definitely needs to consider the advice of a treating healthcare practitioner...


    Lets start it this way... and yes, LowcarbNY is absolutely right - I know my patient's history well, hence the reason why I built this thread as a reminder to everyone in our group that those who are looking to be in a state of ketosis, to do so very carefully, and preferably under the advisement of treating providers - a responsibility that I hold very seriously.




    The syncope she experienced was the first indicator for the need to have blood work - why? Syncopal episodes do not just apply to low blood pressure. In my patient's case it did not relate to blood pressure at all.

    In this patient's case - had her husband not reacted fast enough to get his wife to the ER to get medical attention, she may very well have entered into a Diabetic Coma. Lucky for her, she didnt as ketoacidosis CAN lead to a diabetic coma in rare situations for Type 2 and prediabetics.


    The husband gave detailed information about her intake. Referred the clinic team to her food diary. She averaged 900 calories per day. Most days she had no vegetable intake, just animal proteins, butter, oils, etc. The days that she did consume vegetables, they were extremely marginal. He commented on how his wife was excessively working out at the gym but did not have any positive weight loss changes, the fact that she didnt eat back any calories from her workouts - thus her 900 caloric intake was significantly reduced.

    Her body no longer produced enough insulin - in fact the readings for insulin production were marginal at best.
    On average, her ketostix registered a black color in the morning and again in the afternoon. please take note of this: there are no black colored readings on a bottle of ketostix. Her readings were black by visual, when the urine was measured.

    Several components read extremely high, including protein and ketones. She required an immediate evaluation by a Nephrologist to determine kidney function, if any existed due to the preliminary tests performed. Her saving grace is that her pancreas did not shut down - thus hope for her kidney function.

    As it turned out, her kidneys, for lack of a better way to describe it - pooped out. It could no longer function to remove the copious amounts of acid, aka ketones. The liver also was compromised - it simply did not perform well because it was too busy filtering her blood as fast it could. Her blood was supersaturated with ketones. Where the liver (like the kidneys) is considered a filter, cant work effectively if there's so much contaminant in the blood that it has to get rid of, and has to work even harder to produce more oxygen rich plasma.

    Remember the part where we learned she was over exercising? She clearly was not taking in nearly enough water at all. Our body uses/needs water (among other things) to help flush contaminants away via our urine output. The liver dumps into it, the kidneys dump into it, travelling down the ureters, into the bladder and out the urethra. If you dont have enough hydration (again, another common issue for some low carbers), the body cant get rid of the contaminants the body is trying to get rid of.....


    This patient did not just do a two week course of Atkins - she took it to an extreme level of two months and pair it up with large sessions of exercise, lack of adequate proper hydration, poor dietary intake, severe caloric reduction. Her body is carrying almost 300lbs (if memory serves me right she weighed 297lbs, as reported by her husband from the last physical she had with her PCP)

    When asked whether or not the wife understood that this was not the avenue instructed of her by the Endocrinologist, the husband admitted to the clinical team "she was desperate to get a jumpstart on losing weight, read all about how people lost alot of weight really fast, and she thought she could do better".

    Her care-plan almost three months ago was an 1800 calorie/day restriction. Her total daily carbohydrate restriction was no more than 140g per day, the bulk of the carbs were to be consumed in the morning provided she balanced it with at least 50g of protein. She was required to do a food elimination of everything having to do with breads, flour, rice, pasta, corn and all white potatoes. She was advised to only consume no more than two servings of fruit - preferably from the berry family as outlined in the glycemic index - a medically sound resource from the University of Sydney. This was due to her extremely high insulin readings from the last fasting blood work performed. She was also told to only consume real whole foods which meant a total clean up of her daily dietary intake. The husband could not respond because he was in shock... he claimed to have not known about any of those restrictions citing that his wife never shared the information with him, and thought what his wife was doing was exactly what she was told to do.

    She was put on IV fluids and Insulin therapy immediately. A serious interventional educational session was held with both the patient and her husband on the serious nature of the current situation. The patient was actually embarassed that things ended up the way they did. The first 24 hours was to get her stabilized. She was tested again in the morning - her ketones had improved but were still very high. She received nutritional advice from an RD working the floor for patients who are under medical/food related restrictions and showed her how she could still have a complete meal while balancing everything out, again - under the Endo's previous medical advice and guidelines. By the end of day two, she was able to eat an actual dinner as they gradually decreased the insulin treatment. Her newer test results were improving - but not enough to discharge her.

    Have you ever seen surgical specialists get rip-roaring angry? I see it every day when physicians come face to face with a patient who was clear-as-day defiantly going against medical advice. Their situations could have been handled correctly had the patient made the right choice to listen to the advice that was given to her. This woman was so desperate that it nearly cost her own life. She is the rare case that can happen and full blown, at that.

    LowcarbNY - everything you said is a carbon-copy of what happened to her: hydration compromised, extremely poor nutrition, paired with excessive exertion via exercising and not replenishing anything fluid-based or food-based, and on top of that, it not only flared her current medical conditions, but developed new ones that sent her to the hospital.


    Morbid Obesity
    High Blood Pressure
    Dysmetabolic Syndrome X (this family includes hyperinsulinemia)
    Hirsutism
    Hypersecretion of Ovarian Androgens
    Severe Ketoacidosis (new)
    Unspecified Renal Failure (new)


    Again, this patient represents the rare cases that happen.

    This should be considered a reminder that it ****can**** be any of us. Diabetics, PreDiabetics, no diabetics... its not often with the type 2 variety - but this was an example best shared with here in our group - its a reminder to not be afraid of foods... be more mindful of what you are eating and by all means - if a treating clinician is giving you sound advice (one that is realistic, which for the subject matter, it was very realistic for her pt), swaying away from said advice will potentially subject you to compounding the problems, if not increasing others to manifest.


    Not trying to sound like a "Direct TV" commercial but it needs to be said: Dont be like this patient and ignore your healthcare physicians' recommendations"...

    Thank you,


    CramerNH
    Moderator
    Low Carber Daily Forum
This discussion has been closed.