I did take my liquid levothyroxine at night for a while. I was having trouble with my throat which made getting to sleep more problematical, at first I split the dose, the luxury of liquid, then made a full change. After a few weeks the problem subsided and I reverted to mornings. I don't have the same need to delay breakfast as much as someone on pills has.

As long as a time lapse of two hours has passed after food, I have read that this is acceptable. Your own doctor would have their take on this. I wonder if while sleeping and making no other demands on one's body, would this facilitate uptake for those who's needs are possibly more sensitive, as mine had been.

I usually take it first thing when I get up. I find I'm really sluggish in the mornings though and have a hard time getting out of bed. When I would take it before bed, if I didn't go to bed right after taking it, I would be up for some time unable to sleep. I'm thinking of splitting my dose but I dunno.

I take Synthroid & Cytomel. They have to be taken with a large glass of water on an empty stomach (at least 2 hours after eating or drinking anything but water) and at least 4 hours after taking any supplements (vitamins, minerals, fiber, etc.). You can't eat or drink anything but water for an hour after taking them.

Synthroid can be taken any time of day, as long as it meets all the above conditions. I take mine in the morning, then wait an hour before breakfast. (I often eat within two hours of bedtime, so I couldn't take it then.)

Cytomel is trickier. It has a short half-life, so you have to take it several times a day. My endocrinologist wanted to prescribe it 3x a day, but that would mean nothing but water for a minimum of 6 hours every day! We compromised on taking 2 pills in the morning (with the Synthroid), then one dose in the afternoon.

I set a timer for 2 hours when I finish lunch, and eat or drink nothing but water. I take the Cytomel, then set the timer for another hour. When it goes off, I cheer! That's 4 hours a day of nothing but water. I keep my pills & a glass of water on my bedside table, and take them whenever I wake in the middle of the night. It's such a luxury to wake the next morning and not have to wait for breakfast.

The reason for all this waiting is to enable your body to properly absorb the meds. I might be able to "fudge" it by waiting 30 minutes rather than an hour after taking them, but for me the risk of hypo symptoms just isn't worth it. YMMV.

I take synthroid and cytomel in the A.M. and more cytomel at 1 P.M. I found if I take it at night I am awake forever. I am very sensitive to medication, so you may not have this problem. I do wait an hour after taking my meds in the A.M.

I take mine at bed time. That way I have had nothing to eat for several hours and won't be eating in my sleep either. Never been kept awake by taking it at night but I suppose I am already asleep when it kicks in. My Doc said it was the best time to take it.

I take my westhroid pure in the morning when I first wake up and then wait to eat until an hour afterwards. Works good for me

I take mine first thing in the morning after my workout. My bed time routine varies too much for me to be able to remember to take anything consistently, so the best thing for me is morning - because drinking coffee will ALWAYS BE MY ROUTINE.