GABA (gamma-Aminobutyric acid) is a naturally occurring, self-regulating, chemical compound produced in the brain. The primary purpose of GABA is to reduce the excitability of neurons. Thus, it is considered an inhibitory neurotransmitter that partakes in suppressive activities. Most notably, GABA works to suppress excitatory neurotransmitters norepinephrine and glutamate (GABA’s metabolic precursor). GABA is intimately involved with the parasympathetic nervous system (PNS). The PNS (a part of the autonomic nervous system) is primarily responsible for energy conservation at rest.
GABA’s calming effect isn’t just mental, but it’s physical as well. Since GABA plays a significant role in muscle tone regulation, it can reduce muscle spasms helping to create a state of physical relaxation. Often, the best nootropics for mood enhancement act in the same manner. Reducing stress, anxiety, increasing serotonin and relaxing the user all work to create a more positive mood in the individual.
Past studies have confirmed that GABA is the primary inhibitory neurotransmitter in the central nervous system (CNS). The levels of this important neurotransmitter are affected by poor diet, illness, or exposure to environmental toxins. Studies show that GABA levels also decline with age. An insufficient amount in the body may lead to anxiety, irritability and sleep disorders like insomnia. GABA levels are also lower in people with ADHD.