How Metformin reduces blood glucose (Technical)
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RalfLott
Posts: 5,036 Member
Here's a Pubmed summary:
https://www.ncbi.nlm.nih.gov/pubmed/24847880
Full text:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074244/
Review:
http://high-fat-nutrition.blogspot.com/2015/11/just-brief-note-on-metformin.html
"The rising level of NADH under metformin (due to blocking this oxidation of NADH) makes the conversion of lactate to pyruvate energetically impossible and so lactate derived gluconeogenesis stops on a redox basis. The conversion of glycerol to glucose via glycerol-3-phosphate is impossible using mtG3Pdh because metformin specifically blocks this enzyme."
@KnitOrMiss
https://www.ncbi.nlm.nih.gov/pubmed/24847880
Full text:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074244/
Review:
http://high-fat-nutrition.blogspot.com/2015/11/just-brief-note-on-metformin.html
"The rising level of NADH under metformin (due to blocking this oxidation of NADH) makes the conversion of lactate to pyruvate energetically impossible and so lactate derived gluconeogenesis stops on a redox basis. The conversion of glycerol to glucose via glycerol-3-phosphate is impossible using mtG3Pdh because metformin specifically blocks this enzyme."
@KnitOrMiss
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Replies
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Very interesting. That last link especially led to a blog with a lot to read. So much so that I forgot about the chewing and swallowing part of my lunch for so long that the protein portion got cold.4
