autobahn66 Member

You said that calories: 'Also, while logic dictates that exercise does consume extra calories, and it really does, clinical evidence also shows that these values are quite small, and virtually undetectable' That is just factually untrue. Calories burned in exercise, based on exercises that can be done in a lab, are pretty…

Sure. A 500 kcal deficit is 85ml of oil. 80g. We don't know what the OP did to reduce their calorie intake, but if they were eating at maintainance before then the amount of food intake may be as little as 80g a day less. And maybe they're eating a bunch of veggies now? Lots of bulk. Now I know when I eat less fat, I eat…

Have I become confused? Everyone in this thread is acting like there is some long plateau here and that there must be no caloric deficit. It hasn't even been three weeks: 18 days since Christmas. In my book that is too short a time to see significant changes, particularly given the relatively modest deficit of 500/3500…

Hey all. First time posting here! But everyone IRL is sick of hearing about my runs, and you all seem so supportive. In terms of a goal: I'm aiming to complete 2500km this year - on 2355km - so 145km to go over the next 17 days. Inclement weather here has meant solid ice and packed snow on the pavements, which always makes…

You're not wrong here, but you're missing the point of what the doctor said. There is a very fundamental way in which type II diabetes with pancreatic insufficiency is like type I diabetes: without insulin the patient will become extremely unwell, possibly quite quickly. Furthermore, the clinical presentation of HHS…

Hey Lee, sorry you are having such a difficult time, and glad to hear you are feeling better. With regard to your weight: one thing to consider is that the weight of a person going into hospital will have been artificially low if they are in a hyperosmolar hyperglycaemic state. As their blood sugar is so high, the sugar in…

I can personally attest to this! I lost 23kg in 6 months between July and December 2021. Got to my initial target weight and started maintenance for a few months. Restarted attempting to lose weight through the year a couple of times. In the meantime I started properly running - ran a marathon in April - and have done…

@middlehaitch Canadian obesity guidelines are published by Obesity Canada, here. And the associated publication can be seen here. And the recommendations are to consider pharmacological management in anyone with BMI >30 or people with adiposity-related conditions and BMI >27. All of this should be in conjunction with other…

This paper examines extensively the association between BMI and mortality by a variety of causes (which I would contend is a decent, but limited, measure of health). It shows clearly a J shaped curve, with the nadir of mortality around a BMI of 21-25 (see table 2 for the 'change point' for each condition: these are…

I firmly disagree. Both that work has value in its own right and that a dedication to work necessarily benefits one's personal life. With regard to good in one's personal life: I come from a traditional background, where work ethic is highly celebrated. I confound my value as a person so highly with my work, and with my…

I think it's easy to get disheartened in this situation. And the reality is that the omicron wave is going to have huge numbers - in part because of effective methods for reducing spread in 2020 and 2021 means fewer people were exposed, fewer people died etc. But the numbers of deaths/the case fatality rate is going to be…

I disagree with the point that you should look to bloodwork to tell you if you are 'healthy' or not. Bloods can be abnormal for lots of reasons, and often are not reliable indicators of a disease state. Are the LFTs abnormal randomly - as 5% of tests will be? (N.B. the normal ranges are just standard deviations in a…

I would go further and say I lost weight because of gout. My diagnosis helped me realise that it was necessary to change my behaviours: both to prevent flares, but also for my long-term health. Down 20kg since July, but also so much fitter: running 5-10k three times a week and - best of all - no flares of joint pain for…

There's another aspect to it: if we assume that a new variant specific vaccination is required because the immune response to the initial vaccination doesn't do a good job recognising it (particularly in the parts of the spike protein responsible to actually binding the host cells) then should we assume that the prior…

I agree with this. It is common to get multiple vaccines at the same time, either of the same pathogen (flu is three or four strains. Strep. pneumo is 13 or 21 strains) or of different pathogens (MMR, DTaP). There is no specific harm: the question is can you get enough of each specific target in to get good efficacy…

I think he's right that there will be a time where sufficient people are immune (through recent vaccination or infection) such that we will reach a steady state of infections - likely with a seasonal trend, rather than the 'waves' we are seeing now. But there are a number of questions or issues: 1. The range of severity of…

Just chiming in as this piqued my interest in my own data and fully agree with all the posters above. I am 180cm with a start weight of 123.9kg on July 22nd (but the graphs here start at c.118kg and August 5th as the numbers are not easily interpretable before this date due) and was 104.4kg this morning, making my weight…

Both remdesivir and paxlovid (Pfizer's new drug) have their own issues, but are not relevant to the discussion about ivermectin. (For one I can't wait to see the resistance data after exposure to paxlovid given the nature of rapid resistance to oral antiviral medications, but the outcome of EPIC-HR is very interesting, and…

In silico is just a dumb way of saying modelled by a computer, and has been done in all areas of biology since the advent of computers. In this case the modelling of interactions of small molecules and proteins is not pharmacokinetics, but essentially structural biology. Proteins are generally very complex molecules and…

Just for clarity: that meta-analysis includes the now-infamous Elgazzar study which was shown to include falsified data, and the primary author has had a recent article regarding the MATH+ protocol for COVID retracted as outcome data was falsified. see here. And has generally worked unscientifically during the pandemic to…

I notice you mentioned you are eating 1000 net calories: are you then correcting total calories by estimating calories burned in exercise? One issue that comes up frequently is that counting calories burned in activity and exercise is highly inexact (moreso for some methods than others), so eating back 100% of estimated…

Certainly in Ireland when I was young, all weights were in stones and pounds. There has been a general move to kg, and certainly for formal weights taken in hospital etc kg is the only scale that is used. Most mechanical scales have a dual measure like so. It is somewhat disheartening to hear that you weigh as much as 19…

That is certainly my experience. And I find that it is not only when an obese person posts asking for advice, but moreso in the discussion threads where the tone can be more difficult. I have definitely seen people write that the discussion threads do no need to be supportive and that people should look elsewhere for…

This article says nothing about fatigue. And you can measure how BEE changes with physical activity: it's right there in the paper. It's not a miracle of science: it's measuring how much CO2 someone is producing. You started this by making a definitive statement that this was click-bait: but you haven't shown an ounce of…

A few comments: MFP is based around calorie counting, but also has an adjustment for exercise which is applied very blandly with no comment or recognition of a) the problems with measuring/recording calories burnt, or b) what this shows, which is that BEE/BMR is affected by calories burned in exercise. I think that's…

TDEE was measured by doubly labelled water, a scientific method which (somewhat) accurately measures the total amount of CO2 produced by the body. Calorie intake and weight change are not particularly relevent to energy expenditure, other than the thermogenic effect of food, which was (broadly) accounted for.

This is an ill-informed comment, which adds no value to the discussion. They used flow-through respirometry to measure basal energy expenditure and double-labelled water to measure total energy expenditure. The study showed clearly an underlying compensatory process which reduced basal energy expenditure in response to…

I, like a few others, break the rules and weigh twice a day! I then input the values into a table and have lines for daily max/daily min, and a 7 day moving average. I can then use the values to calculate my actual energy expenditure over a period, and review the changing rate of weight loss, and trends on a weekly/monthly…

I love this take: there's a fundamental truth to it. How DO you know what the body is going to do with 1 kcal of sugar, or fat or protein? Is what your body does and my body does with that calorie different? How many of those calories are needed to keep me alive, vs feel good, vs maintain muscle mass, vs add fat? Except…

Heh! I'm the exact opposite: my limit is as low as I think is safe, then I eat slightly over it most days. I'm not a huge fan of the red numbers, but I will eat every calorie up to that line, so I need it to be quite low. There are a couple of ways the messaging might be better for me: I don't so much have a single calorie…