Quelling Inflammation with Ketosis
Options
wabmester
Posts: 2,748 Member
New paper. Prestigious journal.
Quelling Inflammation with Ketosis
It's just a short article, but it touches on the mechanism of ketones quelling inflammation:
The authors ultimately show that BHB turns off NLRP3 activation of caspase-1 by inhibiting potassium efflux from cells, similar to its putative active function in quieting neuronal excitability in epilepsy. They wrap up their work with an elegant demonstration in vivo using a ketogenic diet to blunt inflammation and limit end-organ damage in a mouse model of Muckle-Wells syndrome. Paleo diet, anyone?
Should we recommend extreme low-carb diets to our patients with inflammatory diseases or wait for an inhibitor to make it through the trials and tribulations of, well, trials? The American cultural anthropologist Margaret Mead once declared, “It is easier to change a man’s religion than to change his diet.” If this is the case, let us pray that food becomes the new religion or at least grant us pharmacologic inhibition of the inflammasome, which may protect us from danger signals, forgive us our dietary sins and repair our inflammatory injuries.
Quelling Inflammation with Ketosis
It's just a short article, but it touches on the mechanism of ketones quelling inflammation:
The authors ultimately show that BHB turns off NLRP3 activation of caspase-1 by inhibiting potassium efflux from cells, similar to its putative active function in quieting neuronal excitability in epilepsy. They wrap up their work with an elegant demonstration in vivo using a ketogenic diet to blunt inflammation and limit end-organ damage in a mouse model of Muckle-Wells syndrome. Paleo diet, anyone?
Should we recommend extreme low-carb diets to our patients with inflammatory diseases or wait for an inhibitor to make it through the trials and tribulations of, well, trials? The American cultural anthropologist Margaret Mead once declared, “It is easier to change a man’s religion than to change his diet.” If this is the case, let us pray that food becomes the new religion or at least grant us pharmacologic inhibition of the inflammasome, which may protect us from danger signals, forgive us our dietary sins and repair our inflammatory injuries.
0
Replies
-
Great article! I sure hope some gastroenterologists read this and take it to heart! They could help so many people and don't even realise it!
I also feel that almost every area of medicine could see benefits from ketosis! There seems to be more leanings this way recently! Slowly they may be learning!0 -
My joint/muscle pain dripped like a rock in 30 days after I got off most sugars and all forms of grains. It was more like six months before my 40 years of IBS fully resolved. It seems the gut needed some healing time perhaps?
Personally I have not found an upside/requirement for carbs as long as I have access to protein and fats.0
This discussion has been closed.