Protein overload may help prevent type 2 diabetes?

aakaakaak

Looking through studies I came across one talking about how nutrient overload leads to obesity, insulin resistance and type 2 diabetes. However, it goes on to further explain that because of a protein called S6 kinase 1, protein overloading may actually help prevent insulin resistance, ergo type 2 diabetes.

http://www.cell.com/cell-metabolism/retrieve/pii/S1550413106001586

Was that a correct assessment of the study? Anybody who can read science-ese?

If this is the wrong place to put this let me know and I'll stick things like this somewhere else in the future.

verdemujer

I'm bumping for later. To tired at the moment to read a bunch of science style language.

Sarauk2sf

I have heard something to the effect before, but nothing conclusive. Tagging to read, but it will probably be above my pay grade.

aakaakaak

There's a paywall, so all you really get is the conclusion. It's from 2006, so its not a new thing.

neanderthin

Here is a more in depth explanation.

http://pubmedcentralcanada.ca/pmcc/articles/PMC2587347/

And one a little easier to read.

http://diabetes.diabetesjournals.org/content/55/8/2392.full

aakaakaak

And one a little easier to read.
http://diabetes.diabetesjournals.org/content/55/8/2392.full

So link one....

Conceivably, a combination of both increased expression of p85α and increased serine phosphorylation of IRS-1 is needed to induce clinically apparent insulin resistance.

When p85α is out of whack it causes problems with your insulin receptors, increasing your changes of type 2 diabetes. p85a imbalance can be caused by GH, hPGH, Steroids, Overfeeding, Obesity and T2DM. (I have no idea if these are commonly understood acronyms, but they're not to me.

And link two...

Excess levels of circulating amino acids (AAs) play a causal role in specific human pathologies, including obesity and type 2 diabetes. Moreover, obesity and diabetes are contributing factors in the development of cancer, with recent studies suggesting this link is in part mediated by AA activation of mammalian Target Of Rapamycin (mTOR) Complex1. AAs appear to mediate this response through class 3 PI3K, or hVps34, rather than through the canonical class 1 PI3K pathway used by growth factors and hormones....and a whole bunch of other words I can't pronounce or understand.

Does this mean that an overabundance of amino acids (class 3 PI3K, or hVps34) in the bloodstream "that go unused" lead to insulin receptor insensitivity, and type 2 diabetes, and an increased chance of cancer? Actual causality of type 2 and coincidental for cancer.

Thanks for the links, but now I'm deeper and far more over my head than expected. The last link makes organic chemistry look simple by comparison.

Kitship

Bump for later!