Introduction - T2D
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While a hypocaloric diet alone will slowly deplete glycogen stores, I was simply emphasizing the best way to do it quickly.albertabeefy wrote: »FYI, if you really want to deplete glycogen stores quickly, the best way to deplete liver glycogen is through fasting. Low-carb/hypocaloric with ONLY enough protein to maintain lean tissue is next.
To carry it to the next-level, do an all-over body weight-training circuit (work the shoulders, biceps, triceps, back, glutes, hamstrings, quads and calves) to fully-deplete muscle glycogen as-well.
There are data-based studies documenting hypocaloric diets depleting glycogen stores (Specifically two studies by Taylor, and a number of post-bariatric surgery studies). Most of what I've found on fasting (and I've tracked down pretty much everything Fung has commented on) is theoretical/predictive. I believe I've found a single reported data-based study supporting the use of fasts extending at least 14 hours (going from memory).
You could do it faster if you simply went out and ran a marathon, of course, but I don't consider that even remotely enjoyable and, as-such, would never consider it the 'best' method. =P
Plain fasting will fully deplete liver stores in as little as 28hrs according to Cahill, et.al. Muscle glycogen is a whole different issue ... Even after 24hrs it's hardly been touched, except with exercise. It's important to remember that liver glycogen can be released to anything in the body requiring fuel, but muscle glycogen is converted to glucose within the muscle cells and is then used strictly by the muscle it's stored in.2 -
This article suggests that with time and a LCHF diet, the liver stores will eventually go down.
https://intensivedietarymanagement.com/dawn-phenomenon-t2d-8/
Last night PP was 113. This morning fasting was 147. Yesterday was a good day with good distribution/pacing of carbs and protein. I will keep monitoring and sticking to my plan. I suspect it will settle down eventually.1 -
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@2t9nty I'm so glad to hear this progress!
Thanks! I have my first A1C Monday since I starting the Metformin and then later started watching carbs. It will be a lot better than when I was diagnosed. I just want to keep making progress. Today was not the best day with two work-related meals, but carbs were 51.3 -
@2t9nty I'm so glad to hear this progress!
Thanks! I have my first A1C Monday since I starting the Metformin and then later started watching carbs. It will be a lot better than when I was diagnosed. I just want to keep making progress. Today was not the best day with two work-related meals, but carbs were 51.
Good Luck! As to the A1C, remember that it roughly corresponds to the last 3-4 months - so the early days (when you weren't doing low carb) will be in there (as well as, likely, some pre-diagnosis days). It should be lower - but it may not be as muchlower as you are hoping for.0 -
@2t9nty I'm so glad to hear this progress!
Thanks! I have my first A1C Monday since I starting the Metformin and then later started watching carbs. It will be a lot better than when I was diagnosed. I just want to keep making progress. Today was not the best day with two work-related meals, but carbs were 51.
Good Luck! As to the A1C, remember that it roughly corresponds to the last 3-4 months - so the early days (when you weren't doing low carb) will be in there (as well as, likely, some pre-diagnosis days). It should be lower - but it may not be as muchlower as you are hoping for.
I hear you. I am somewhat determined here, but I know progress will be incremental. Sabotaging my own efforts I neglected to take meds before leaving the house this morning. Three services, supper club, and about 11 hours later I got back home and BG was 140. This is not really that bad, but I know there will be lots of old data in there too.1 -
I had my appointment. I had lost 6 pounds and blood pressure was good. The A1C came back as 6.9. It is not that great, but I looked back on my meter, and my first reading under 200 was October 8. Some of the early numbers when I was following the ADA diet were scary high. My doctor had set an A1C of 7 as my goal for his appointment, and he did not want me to gain weight over the holidays. I met those two goals anyway.5
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I had my appointment. I had lost 6 pounds and blood pressure was good. The A1C came back as 6.9. It is not that great, but I looked back on my meter, and my first reading under 200 was October 8. Some of the early numbers when I was following the ADA diet were scary high. My doctor had set an A1C of 7 as my goal for his appointment, and he did not want me to gain weight over the holidays. I met those two goals anyway.
I would say from 12.8 in October to 6.9 now is a win. We all want to get below pre-diabetic levels, but it generally is not going to happen overnight. Three month change of 5.9 is about as close to overnight results as could be reasonably expected.1 -
Great progress!
Your current BG readings are a better guide than A1c anyhow, as long as you're testing frequently (which is highly encouraged - only real way to know how you're reacting to different variables, and it won't take that long to figure out!).
Stay the course - time and dedication are our chums.0 -
My next appointment is in 6 months. I have made progress here. I was hoping for a little lower in the 6's, but I am getting better at all this. Progress is progress.1
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You have a good attitude - I'm guessing you will be doing swimmingly come beach weather!1
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Sabotaging my own efforts I neglected to take meds before leaving the house this morning. Three services, supper club, and about 11 hours later I got back home and BG was 140. This is not really that bad, but I know there will be lots of old data in there too.
Metformin is not a short-acting drug, so forgetting your medicine should not have impacted your BG 11 hours later (and, as long as it's only once in a while should have no bigger impact, either.)
Congrats on the dramatic improvement in your A1C!
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Thanks all! I am gaining some familiarity with metformin too...1
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Sabotaging my own efforts I neglected to take meds before leaving the house this morning. Three services, supper club, and about 11 hours later I got back home and BG was 140. This is not really that bad, but I know there will be lots of old data in there too.
Metformin is not a short-acting drug, so forgetting your medicine should not have impacted your BG 11 hours later (and, as long as it's only once in a while should have no bigger impact, either.)
Congrats on the dramatic improvement in your A1C!
That's not my experience with Metformin XR, or at least it wasn't last time I was stuck somewhere without it - generally, if I didn't take it in the morning and ate a large meal later in the day, my BG would be up.
Dr. Bernstein even suggested using IR Metformin before meals, and I believe I saw an article on Pubmed to that effect. (Of course, your GI system has to tolerate it on an empty stomach...
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I'm within 5 lbs of my target weight, and after I hit it, I plan to wait 3 months, get all my bloodwork done, then try systematically reducing my meds - maybe things will have changed since my last (unsuccessful) attempt.0
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