Vitamins & Arterial Stiffness

RalfLott

Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266829

A bit of a mouthful, but pretty interesting.....

CONCLUSIONS:
There is a complex relationship between vitamin status and arterial stiffness, and each vitamin has specific effects on the vascular wall. Vitamin supplementation may be an effective and inexpensive adjunctive therapy in several conditions associated with increased arterial stiffness and they should be implemented in patients' diet, considering individual vitamin status.

Vitamin D deficiency, involved in the pathophysiology of cardiovascular disease, may be an important therapeutic target. Despite heterogeneity and conflicting results of trials on vitamin D supplementation, arterial stiffness was significantly decreased in children with chronic kidney disease, black adolescents, adults with vitamin D deficiency with or without prehypertension, nondiabetic patients with hyperglycemia or positive diabetes score, and type 2 diabetic patients with nephropathy. Further large, randomized, evidence based, follow-up studies, including subjects with several other disorders, will demonstrate if vitamin D level is a marker of subclinical atherosclerosis, an effective target in cardiovascular prevention, therapy, destiffening, and vascular protection, or just a marker of poor health status, and which is the most effective form and level of vitamin D.

Vitamin K was beneficial in decreasing arterial stiffness in healthy postmenopausal women, patients with a history of vascular or coronary artery disease, vitamin E in subjects with type 1 diabetes mellitus and chronic kidney disease, and vitamin C in smokers, late perimenopausal, and postmenopausal women, and patients with type 2 diabetes mellitus. The combination including vitamin C and E could play an important role in cardiovascular disease prevention in young participants with lower baseline plasma levels, resulting in decreased arterial stiffness in patients with chronic obstructive pulmonary disease and essential hypertension. Further studies are needed in order to explore the effect of vitamin A supplementation on arterial stiffness, considering the antioxidant effect of vitamin A, its effect on endothelial function, metabolic profile, and its anti-inflammatory effect. Vitamin B12 supplementation was demonstrated to reduce arterial stiffness in patients undergoing hemodialysis.

The divergent results and mismatch between epidemiological and interventional studies warrant further investigation, but vitamins A, B12, D, K, C, and E may be markers of arterial stiffness and cardiovascular health. Cardiovascular prevention guidelines should consider and include trials with positive results. Vitamin K2 and low dose vitamin D have promising potential for prevention of vascular calcification. The potential public health importance of vitamin level and supplementation remains to be further tested in stratified intervention studies, and future research should focus on optimal vitamin levels and identifying patients who would benefit most from vitamin supplementation in order to enable individualized therapy, a personalised approach, and early interventions in primary, but also secondary prevention of cardiovascular disease.

SuperCarLori

Thank you for sharing. Better up my vitamin c!!

GaleHawkins

I have only learned this over the past two years. It is not common knowledge yet can be the matter of life and death for some of us with long term chronic inflammation.

TheDevastator

Proof that people need the full spectrum of vitamins and minerals not just a few choice supplements.

tcunbeliever

My husband was able to lower his blood pressure with C and lysine supplementation...he went from 160/130 down to 140/70 in about a week, which seems totally crazy to me, but at least it seems to be working.

GaleHawkins

SuperCarLori wrote: »

Thank you for sharing. Better up my vitamin c!!

@SuperCarLori below is the best value that I have found for a Lysosomal C source. If one was fighting a major health issue the gallon size from Healthy Drops is the best value that I have found.

healthydrops.net/index.html

I am only taking 6 grams late each evening because Poly MVA and Vitamin C can compete with each other in theory and Poly MVA is about $3200 per gallon vs $299. I take Poly MVA about an hour before each meal on an empty stomach.

SuperCarLori

GaleHawkins wrote: »

SuperCarLori wrote: »

Thank you for sharing. Better up my vitamin c!!

@SuperCarLori below is the best value that I have found for a Lysosomal C source. If one was fighting a major health issue the gallon size from Healthy Drops is the best value that I have found.

healthydrops.net/index.html

I am only taking 6 grams late each evening because Poly MVA and Vitamin C can compete with each other in theory and Poly MVA is about $3200 per gallon vs $299. I take Poly MVA about an hour before each meal on an empty stomach.

Thank you!

GaleHawkins

https://eurekalert.org/pub_releases/2011-03/mg-ssp030111.php

PUBLIC RELEASE: 2-MAR-2011
Study shows pine bark naturally improves kidney function in patients with metabolic syndrome
Research reveals Pycnogenol demonstrates kidney protective benefits and lowers elevated blood pressure and blood sugar.

@SuperCarLori and others I just found this research on Pycnogenol. It actually reduced BMI over a 6 month period.

I am starting to think between Pycnogenol and Wobenzym many potential major health problems may be prevented if not reversed.

SuperCarLori

GaleHawkins wrote: »

https://eurekalert.org/pub_releases/2011-03/mg-ssp030111.php

PUBLIC RELEASE: 2-MAR-2011
Study shows pine bark naturally improves kidney function in patients with metabolic syndrome
Research reveals Pycnogenol demonstrates kidney protective benefits and lowers elevated blood pressure and blood sugar.

@SuperCarLori and others I just found this research on Pycnogenol. It actually reduced BMI over a 6 month period.

I am starting to think between Pycnogenol and Wobenzym many potential major health problems may be prevented if not reversed.

I'll do some reading, I'm fascinated by this type of thing. Thanks, Gale!

GaleHawkins

greenmedinfo.com/substance/pine-bark-extract
This source is a ton of science behind Pycnogenol.

franklintnvet.com/pycnogenol-pet-treatments/
Having a dog and many cats that are getting old I was happy reading about this vet in Nashville experience with Pycnogenol.

Keep in mind Pycnogenol is from pine bark which is cheap on the web but not all pine bark supplements are Pycnogenol. Would any pine bark supplement be just as good. There just is no way for the consumer to know so I will pay more to know its content.

Pycnogenol (since the 1980's) and Wobenzym (since the 1960's) both come out of German based companies and have many years of research data and usage histories. My healthcare education leads me to trust data over say a product from China, etc with no data that would stand up in a court of law.

We are going to die someday but I really really really want to be walking and talking until that day comes.

With that being said I am convinced we need Vit D with K2 to get our levels above 50 ASAP and in the 75-100 range if we have ANY health issues that we hope to recover from. I put Vitamin C just as important.

In the states this is all stuff you can at Walmart and like places. Currently I prefer Healthy Origins Pycnogenol. Off eBay and Amazon 100mg 120 capsule bottles run $60-$65 to the door. The capsules are half the size of Viva brand so I am "guessing" they added a filler(s) but that may or may not be fine.

Best of success and remember just because something comes from nature does not make it safe. In the case of Pycnogenol I have yet to learn of it harming anyone but read your body's take on anything you put into your body.