High Fat Diet Role In Causing Metabolic Syndrome

GaleHawkins

journal.frontiersin.org/article/10.3389/fphys.2016.00498/full

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

In trying to understand if gut microbes do or do not directly use Vitamin D3 before it gets to the blood stream I ran across this science paper. I have skimmed the Results and read the Discussion sections. I was unaware that a high fat diet eaten with a low Vitamin D level could lead to triggering type 2 diabetes in mice. The results of the planned human studies would be great to know and understand.

It does get into the LDL issue with high fat diets I noticed in the Discussion.

I still do not know if a megadose of Vit D3 has a direct impact on gut microbiota within hours or only after the blood levels increases weeks/months later.

GaleHawkins

easy-immune-health.com/Vitamin-D-Side-Effects.html

This info is from a nurse that sells supplements so keep that in mind. I am posting the link because she makes statements about relationships between Vit D3 and other supplements that are news to me in many ways.

Still searching if Vit D3 has any impact on health before it shows up in lab tests which can take a while.

Below is another view on D3 and diabetes.
https://medicalxpress.com/news/2017-05-vitamin-d-doesnt-impact-insulin.html#nRlv

Pain management and Vit D3

medscape.com/viewarticle/759254?pa=RWHhJe5aaqDmrG7cur4PWUgoc9gm%2Feg3np2GLAdIrq%2BYPCiZVewx8lqdw7xQBXPEd%2FsGPYa%2BToEoLjuhFnUEHw%3D%3D

"The women were randomly assigned to receive a single oral dose of 300,000 IUs of vitamin D (cholecalciferol) or placebo 5 days before the time they expected to begin their next menstrual period.

The primary outcome was intensity of menstrual pain as measured by a visual analog scale. The secondary outcome was use of NSAIDs.
After 2 months, baseline pain scores decreased 41% among women in the vitamin D group; there was no difference in scores among women taking placebo (P < .001). The greatest reduction in pain was among women in the vitamin D group who had the most severe pain at baseline (r = -0.76; P < .001)

During the study, none of the women in the vitamin D group needed NSAIDs to manage pain at 1 and 2 months, whereas 40% of those taking placebo used an NSAID at least once (P = .003)."

Pain associated with dysmenorrhea is generally subjective and not easily measured, he added. It is difficult to make conclusions about the effect an agent will have on pain when there is "no convincing biomarker" for the pain, as was the case with this study, said Dr. Lo.

The 300,000 IU dose of vitamin D used in the study is probably harmless if taken every month or 2, and even perhaps every week, but it could cause hypercalcemia if taken daily, said Dr. Lo. The typical vitamin D dose is 400 to 1000 IU/day.

Dr. Lo pointed out that because the participants in the study had vitamin D levels below 45 ng/mL, they were not exactly deficient in vitamin D to begin with. "Most people would say that you're not deficient until you're below 20 ng/ml," he said. "I would say that half the American population is below 30 ng/mL." "