Cholesterol, yeah that.

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  • canadjineh
    canadjineh Posts: 5,396 Member
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    Interesting new stuff sent to my inbox by Peter Attia:
    partial quote with link below.
    In the world of lipidology, remarkable stories about a remarkable therapy, PCSK9 inhibitors. From the early clues provided by the hyperfunction of this proprotein convertase (i.e., a family of proteins that activate other proteins) in gain-of-function mutations in the PCSK9 gene linked with hypercholesterolemia — to the flipside — rare people with loss-of-function mutations linked with big reductions in CHD risk, and low cholesterol levels, particularly LDL-C. How low? Around 15 mg/dL! What might be more remarkable is how quickly everything has unfolded. PCSK9 was unheard of prior to the 21st century (2003, in fact). It’s humbling and heroic (and, currently, expensive). To witness these kinds of scientific insights translate into effective treatments in little over a decade almost feels superhuman. But it’s also as if biology is looking at us, winking, as if to say, ‘you have no idea just how little you know about me.’
  • ToxDocAR
    ToxDocAR Posts: 49 Member
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    Total cholesterol ~260 eating SAD. Total cholesterol ~160 eating lowcarb/keto. Cholesterol is a RESPONSE (inflammatory) to what you eat (specifically carbohydrates and carbohydrates combined with fat), not from it.