Nighttime fasting may foster weight loss, LA Times...
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Method_One
Posts: 58 Member
Intermittent fasting is getting a little more main stream publicity. This article gives an ever so brief description of a recent mouse study on the 8/16 eating pattern and follows up with the obligatory counter point quotes. For extra fun wade through some of the user comments!
An excerpt of the article is below, follow the link for full text...
http://articles.latimes.com/2012/may/18/science/la-sci-fasting-diet-20120518
Nighttime fasting may foster weight loss
A study involving mice suggests that someone on a high-fat, high-calorie diet can stay lean with sufficient fasting between day's end and breakfast the next morning.
May 18, 2012|By Melissa Healy, Los Angeles Times
In an age of long commutes, late sports practices, endless workdays and 24/7 television programming, the image of Mom hanging up her dish towel at 7 p.m. and declaring "the kitchen is closed" seems a quaint relic of an earlier era.
It also harks back to a thinner America. And that may be no coincidence.
A new study, conducted on mice, hints at an unexpected contributor to the nation's epidemic of obesity — and, if later human studies bear it out, a possible way to have our cake and eat it too, with less risk of weight gain and the diseases that come with it.
Just eat your cake — or better yet, an apple — earlier. Then wait 16 hours, until breakfast the next morning, to eat again.
"We have to come up with something that is a simple alternative to calorie counting," said Satchidananda Panda, a regulatory biologist at the Salk Institute in La Jolla who led the study published online Thursday by the journal Cell Metabolism.
Panda and his team put groups of mice on different eating regimens for 100 days. Animals in two of the groups dined on high-fat, high-calorie chow. Half of them were allowed to eat whenever they wanted, and nibbled on and off throughout the night and day. The other mice had access to food only for eight hours at night, when they were most active.
In human terms, this would be rough: No ice cream while watching "Glee." No second glass of wine while talking things over with the spouse. Not even a late-night glass of warm milk.
The difference was astonishing. Even though they ate a high-fat diet, the mice who wrapped up their eating day early and were forced to fast for 16 hours were lean — almost as lean as mice in a control group who ate regular chow. But the mice who noshed on high-fat chow around the clock became obese, even though they consumed the same amount of fat and calories as their counterparts on the time-restricted diet.
Extra weight wasn't their only problem. The obese mice developed high cholesterol, high blood sugar, fatty liver disease and metabolic problems. The mice who ate fatty food but were forced to fast showed hardly any signs of inflammation or liver disease, and their cholesterol and blood sugar levels were virtually indistinguishable from those of mice who ate regular chow. When put on an exercise wheel, they showed the most endurance and the best motor control of all the animals in the study.
The data suggest that the stomach, the brain and the body's digestive machinery need to take a break from managing incoming fuel; otherwise, we may be working ourselves into a state of metabolic exhaustion. When combined with high-calorie, high-fat diets, the result is weight gain, a liver clogged with fat, accumulation of cholesterol in the arteries and unused glucose in the blood.
In the mice who fasted for 16 hours daily, measures of digestive hormones, cholesterol and glucose suggested that liver enzymes were working hard to break down cholesterol into bile acids. The body's stores of "brown fat," the stuff that converts extra calories into heat, were revved up, and the liver ceased production of glucose. As they burned fat, their body temperatures were actually higher, Panda said.
The results of daily fasting were "phenomenal," he said.
An excerpt of the article is below, follow the link for full text...
http://articles.latimes.com/2012/may/18/science/la-sci-fasting-diet-20120518
Nighttime fasting may foster weight loss
A study involving mice suggests that someone on a high-fat, high-calorie diet can stay lean with sufficient fasting between day's end and breakfast the next morning.
May 18, 2012|By Melissa Healy, Los Angeles Times
In an age of long commutes, late sports practices, endless workdays and 24/7 television programming, the image of Mom hanging up her dish towel at 7 p.m. and declaring "the kitchen is closed" seems a quaint relic of an earlier era.
It also harks back to a thinner America. And that may be no coincidence.
A new study, conducted on mice, hints at an unexpected contributor to the nation's epidemic of obesity — and, if later human studies bear it out, a possible way to have our cake and eat it too, with less risk of weight gain and the diseases that come with it.
Just eat your cake — or better yet, an apple — earlier. Then wait 16 hours, until breakfast the next morning, to eat again.
"We have to come up with something that is a simple alternative to calorie counting," said Satchidananda Panda, a regulatory biologist at the Salk Institute in La Jolla who led the study published online Thursday by the journal Cell Metabolism.
Panda and his team put groups of mice on different eating regimens for 100 days. Animals in two of the groups dined on high-fat, high-calorie chow. Half of them were allowed to eat whenever they wanted, and nibbled on and off throughout the night and day. The other mice had access to food only for eight hours at night, when they were most active.
In human terms, this would be rough: No ice cream while watching "Glee." No second glass of wine while talking things over with the spouse. Not even a late-night glass of warm milk.
The difference was astonishing. Even though they ate a high-fat diet, the mice who wrapped up their eating day early and were forced to fast for 16 hours were lean — almost as lean as mice in a control group who ate regular chow. But the mice who noshed on high-fat chow around the clock became obese, even though they consumed the same amount of fat and calories as their counterparts on the time-restricted diet.
Extra weight wasn't their only problem. The obese mice developed high cholesterol, high blood sugar, fatty liver disease and metabolic problems. The mice who ate fatty food but were forced to fast showed hardly any signs of inflammation or liver disease, and their cholesterol and blood sugar levels were virtually indistinguishable from those of mice who ate regular chow. When put on an exercise wheel, they showed the most endurance and the best motor control of all the animals in the study.
The data suggest that the stomach, the brain and the body's digestive machinery need to take a break from managing incoming fuel; otherwise, we may be working ourselves into a state of metabolic exhaustion. When combined with high-calorie, high-fat diets, the result is weight gain, a liver clogged with fat, accumulation of cholesterol in the arteries and unused glucose in the blood.
In the mice who fasted for 16 hours daily, measures of digestive hormones, cholesterol and glucose suggested that liver enzymes were working hard to break down cholesterol into bile acids. The body's stores of "brown fat," the stuff that converts extra calories into heat, were revved up, and the liver ceased production of glucose. As they burned fat, their body temperatures were actually higher, Panda said.
The results of daily fasting were "phenomenal," he said.
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Greater detail of the study here:
http://www.sciencedirect.com/science/article/pii/S1550413112001891
Note: mice are nocturnal so the eating only at night would be the day for us...0