Did anyone catch the "Fasting diet 'regenerates diabetic pancreas'" study?
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shadus
Posts: 424 Member
The story I saw was from the BBC- http://www.bbc.com/news/health-39070183 doing some more searching I found a reddit thread linking to it with more info here: https://www.reddit.com/r/science/comments/5vufpb/the_pancreas_can_be_triggered_to_regenerate/
Fasting portion of diet: - http://www.cell.com/cms/attachment/2085214065/2073774756/mmc1.pdf
Cell full article (paywalled): - http://www.cell.com/cell/abstract/S0092-8674(17)30130-7
A related study with pre-diabetics: http://care.diabetesjournals.org.evms.idm.oclc.org/content/29/6/1337.long
*****NOT recommending anyone do this, especially for diabetics on medications a fast could cause serious health ramifications, for something like this it would be *essential* to have the support and monitoring of a doctor.*****
I found some interested stuff posted by a current med student as well such as, "You don't see virtually any effects of type II diabetes until the pancreas has lost 60-70% of its beta cell function. It has been shown on average that the pancreas starts losing beta cells 10 years before noticeable symptoms. So.... yea... also... just because studies haven't looked at the number of beta cells doesn't mean the prior diets haven't increased beta cells. While there are ways, how else would we get increased insulin function and beta cell function without doing so." and "insulin production is usually increased in early stages of type2 and insulin resistance is indeed a early characteristic. However, the increase in insulin production is largely due to beta cells ramping up production individually, and thus can mask cell death. At the time of diagnosis (usually), cell death/exhaustion has beat out the increased production in individual cells, and now we see the changes in glucose levels. So the beta cell death and exhaustion ultimately is what unmasks the disease."
Which kinda blew my mind.
I just thought it was interesting and relevant and gives some hope for the future for many T2s once they get some more trials done, verify it works as expected, and find the safest ways to administer the diet. Anyone else have thoughts on it?
Fasting portion of diet: - http://www.cell.com/cms/attachment/2085214065/2073774756/mmc1.pdf
Cell full article (paywalled): - http://www.cell.com/cell/abstract/S0092-8674(17)30130-7
A related study with pre-diabetics: http://care.diabetesjournals.org.evms.idm.oclc.org/content/29/6/1337.long
*****NOT recommending anyone do this, especially for diabetics on medications a fast could cause serious health ramifications, for something like this it would be *essential* to have the support and monitoring of a doctor.*****
I found some interested stuff posted by a current med student as well such as, "You don't see virtually any effects of type II diabetes until the pancreas has lost 60-70% of its beta cell function. It has been shown on average that the pancreas starts losing beta cells 10 years before noticeable symptoms. So.... yea... also... just because studies haven't looked at the number of beta cells doesn't mean the prior diets haven't increased beta cells. While there are ways, how else would we get increased insulin function and beta cell function without doing so." and "insulin production is usually increased in early stages of type2 and insulin resistance is indeed a early characteristic. However, the increase in insulin production is largely due to beta cells ramping up production individually, and thus can mask cell death. At the time of diagnosis (usually), cell death/exhaustion has beat out the increased production in individual cells, and now we see the changes in glucose levels. So the beta cell death and exhaustion ultimately is what unmasks the disease."
Which kinda blew my mind.
I just thought it was interesting and relevant and gives some hope for the future for many T2s once they get some more trials done, verify it works as expected, and find the safest ways to administer the diet. Anyone else have thoughts on it?
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I'm not sure that a fasting diet, for anything, is the best way to go. I have never been able to fast for more than 24 hours before tests.0
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I think I caught that, and that actually makes sense. I was NPO until further notice for days on end due to pancreas/bowel problems, and that seemed to help clear me up.1
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judyvalentine512 wrote: »I'm not sure that a fasting diet, for anything, is the best way to go. I have never been able to fast for more than 24 hours before tests.
Fasting tends to be disrupted by triggers (remember Pavlov's pooch?), not empty stomachs. I find I can stave of hunger triggered by the smell of food or time of day by downing a cup or two of broth and waiting a while.
Also, reducing carbs pretty much killed the cravings I'd had for decades trying to eat a low-fat diet. What a relief that was!
Here's a simple, short explanation:
https://youtu.be/tgpZl1f0kg0 0 -
The story I saw was from the BBC- http://www.bbc.com/news/health-39070183 doing some more searching I found a reddit thread linking to it with more info here: https://www.reddit.com/r/science/comments/5vufpb/the_pancreas_can_be_triggered_to_regenerate/
I just thought it was interesting and relevant and gives some hope for the future for many T2s once they get some more trials done, verify it works as expected, and find the safest ways to administer the diet. Anyone else have thoughts on it?
Yes! Healthy types of fasting are a far cry from the ADA's defeatist recommendations (which give T2Ds no credit for possessing any willpower whatsoever).
Here's an article just out in one of the online diabetes blogs for physicians on fasting-mimicking diets:
http://www.diabetesincontrol.com/reducing-metabolic-risk-factors-by-temporary-fasting/
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Fung is a big proponent of LCHF and fasting for those with IR. His book, Obesity Code, might interest you.
It really is amazing what fasting seems to be able to do. I try to fast for a weekend or so every few months.1 -
I'll definitely check out the book, that sounds interesting.
Over all, I really just dislike the ADA's recommended diet... I'm sure it works out ok for some people, but it really makes no sense unless you want the effects of being diabetic to continually get worse instead of looking for ways to lessen the impact of it on your life.1 -
I'll definitely check out the book, that sounds interesting.
Over all, I really just dislike the ADA's recommended diet... I'm sure it works out ok for some people, but it really makes no sense unless you want the effects of being diabetic to continually get worse instead of looking for ways to lessen the impact of it on your life.
Why the ADA - a "charity" - is not invested in finding and promoting actual cures for diabetes speaks volumes about where its actual investment is - keeping a steady flow of cash coming in from its noble partners like Coca-Cola, Domino, pharmaceutical companies, etc.
None of these fine corporate citizens would grow their revenue if diabetics and prediabetics around the world actually jettisoned sugar from their diets.......2 -
The story I saw was from the BBC- http://www.bbc.com/news/health-39070183 doing some more searching I found a reddit thread linking to it with more info here: https://www.reddit.com/r/science/comments/5vufpb/the_pancreas_can_be_triggered_to_regenerate/
Fasting portion of diet: - http://www.cell.com/cms/attachment/2085214065/2073774756/mmc1.pdf
Cell full article (paywalled): - http://www.cell.com/cell/abstract/S0092-8674(17)30130-7
A related study with pre-diabetics: http://care.diabetesjournals.org.evms.idm.oclc.org/content/29/6/1337.long
*****NOT recommending anyone do this, especially for diabetics on medications a fast could cause serious health ramifications, for something like this it would be *essential* to have the support and monitoring of a doctor.*****
I found some interested stuff posted by a current med student as well such as, "You don't see virtually any effects of type II diabetes until the pancreas has lost 60-70% of its beta cell function. It has been shown on average that the pancreas starts losing beta cells 10 years before noticeable symptoms. So.... yea... also... just because studies haven't looked at the number of beta cells doesn't mean the prior diets haven't increased beta cells. While there are ways, how else would we get increased insulin function and beta cell function without doing so." and "insulin production is usually increased in early stages of type2 and insulin resistance is indeed a early characteristic. However, the increase in insulin production is largely due to beta cells ramping up production individually, and thus can mask cell death. At the time of diagnosis (usually), cell death/exhaustion has beat out the increased production in individual cells, and now we see the changes in glucose levels. So the beta cell death and exhaustion ultimately is what unmasks the disease."
Which kinda blew my mind.
I just thought it was interesting and relevant and gives some hope for the future for many T2s once they get some more trials done, verify it works as expected, and find the safest ways to administer the diet. Anyone else have thoughts on it?
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