Changes in genetic expression during weight loss

Adipose tissue, once thought to be a dormant receptacle of energy stores and an extra layer of insulation, is a metabolically active organ. Yes, fat cells do function and perform work. According to these researchers, they contain genes that affect immune response, hormonal balance, and even metabolism—all involved in creating a "set point" for weight.

Weight loss is no easy feat, especially when the body finds security in fat. Losing weight can feel like an uphill battle, the yo-yo dieting, and perpetual cycles of weight loss and weight gain do not do anyone any favors. With weight loss the body begins to fight for its fat stores; hormones change, satiety is impaired, and metabolic rate shifts. This resilience, according to researchers, is largely a product of the genes being expressed.

"Future research on the beneficial effect of weight loss should focus on long-term effects assessed after a period of weight stability" recommend the researchers. These results provide exciting insights into the physiology of fat and its genetic adaptations. Anyone can lose weight but, according to the authors, sustaining it is the true battle with true benefit.