mmmm sciencey

a quote from my pathology text:

"Studies in model organisms, from yeast to mammals, have shown that the most effective way of prolonging life span is calorie restriction. How this works is still not established, but the effect of calorie restriction on longevity appears to be mediated by a family of proteins called sirtuins. Sirtuins have histone deacetylase activity, and are thought to promote the expression of several genes whose products increase longevity. These products include proteins that increase metabolic activity, reduce apoptosis, stimulate protein folding, and inhibit the harmful effects of oxygen free radicals. Sirtuins also increase insulin sensitivity and glucose metabolism, and may be targets for the treatment of diabetes. Not surprisingly, optimistic wine-lovers have been delighted to hear that a constituent of red wine may activate sirtuins and thus increase life span!"