How many calories?

What did you use to calculate BMR and TDEE? Both of those numbers seem high. If you calculated them only based off weight and didn't use any body fat percentage numbers, then it is likely that the calculations will be higher than your true numbers are.

Those numbers seem high for losing 2 lbs. per week.

Forget x pounds per week, and make a realistic goal of eating somewhere between 80 and 90% of you TDEE, depending on how comfortable you are limiting your calories by this percentage. The more weight you have to lose, the easier and safer it is to go closer to 80%. So, for a TDEE of e.g. 2300, you should aim for about 1800 calories per day, not 1300 .
And of course remeber to recalculate your TDEE as you lose weight, as it will get lower and lower.

So to lose 2 pounds a week I should eat 1300 calories a day, correct? That's still below my BMR, so that's ok?

Yes, the whole "don't eat below your BMR" thing is nonsense. Remove that confusion and you're good to go.

Is it? I was under the impression you must eat at least BMR as this is the minimum your body needs to function normally? Surely, if you're eating less than, even for a short amount of time, it can be detrimental to health?

I have achieved many fitness goals over the years and being a woman in my late 40's, I quit smoking Jan of 13, have gained about 25lbs since then AND my hormones decided to change up too, so the weight is going around my middle like never before. I started a new career last year as well, so many firsts for me. I have been fit, trim & lean at 125lbs with 16% bodyfat up to early 06, but again, a hormone issue & doc put me on hormones which caused me to gain weight again. Ive struggled with it ever since & have not seen the 125 weight since then. Its been a HUGE struggle!

Having givin all that info...I do research/read a lot on fitness, yet with things changing & my weight distribution in different places as well as metabolism soo slow...Im totally confused as to what to do I think. I workout approx 2-4x/wk, but nothing now is moving at all.

I saw a doctor yesterday (only 2nd time I had seen her) and she said some things that I would consider very wacky. She said for women my age, and all above 50, should eat 1000 calories per day to loose any weight but that more than likely will need to eat that amount of calories forever. *That went against everything I've ever learned on anything weight related. She also can offer a few different weight loss drugs, which I've read the side effects & NO BUENO! When i told her that I have water weight like I've never had, she said I could take a diuretic everyday and be fine!

I do not think her advice was anything I would follow and I probably will switch docs as well. I try to eat very healthy, human food, (no processed junk) hardly have any soda, rare to eat breads, don't drink milk/dairy products but a few x/wk, buy/eat organic most often. Take good quality supplements, use/eat Coconut oil, HR is low & very slow (can get to 35 bpm when sitting) & body temp can be low (mid 96's to 97's).

If I eat the recommended 1200 calories per day as MFP suggests, I do not loose anything, and I chart my exercise as well. Im at a loss as to what to do to shake this up! ANY SUGGESTIONS??