Help! Synthroid and weight loss

I started on Synthroid 50mcg about 6 weeks ago after going to an internist for weight gain, hair thinning, dry skin, fatigue and body aches. She ran blood work and said although my levels were considered "normal" my symptoms told a different story. She started me on iodine replacement first and after 30 days, re-assessed and started me on the synthroid. She told me to keep taking the iodine but I only take it a few days a week as I'm not comfortable taking it everyday after reading about it. There seems to be a lot of controversy surrounding the use of iodine replacements. She also has me on Vitamin D 50,000 IU weekly.
Anyway, I haven't lost a single pound. My clothes feel a little looser but there's no significant change. What did change is this: my energy level increased and my period cycle was two weeks late. I did have cramps - not normal cramps but weird sharp pains in the abdomen and temple headaches that got worse the couple of days before my cycle started. My period is lighter - which is great considering how awful it's been for years - and I don't get exhausted like before.

I take my Synthroid in the morning will a full glass of water. I wait to eat for about an hour and then eat a protein rich breakfast. My doctor told me to eat more protein - 10g to 20g - at each meal and cut out sweets as I am showing up as borderline diabetic now. I do have PCOS which was diagnosed about 15 years ago. Nothing helped with that and the weight gain continued.

It's frustrating because the first week I thought everything was looking brighter but now I'm not sure. The doctor had me do a hormone profile (saliva test) and I'll see her in 2 weeks for the results. She wants to be sure my hormones aren't also playing a hand in all this.

I'll update any info in case it can help someone else. Everyone is unique but sharing info gives us all more to work with and discuss with our doctors so I think it's a good thing.

Hello! I was having the same issues about a month ago (but I wasn't losing much weight at all!) I was tired, head was kind of fuzzy and I felt like I had zero energy for anything. Half way through the day I could have taken a 2 hour nap, but didn't because of work. So I went to my doctor and after some simple blood work, she found that I have hypothyroidism. (Thankfully for an answer, not thankful that I have to remember the pill everyday!)

So now that it's been a month, and we have upped my amount of Synthroid, I am noticing the issues as well with the tummy. It's sort of hard for me to relate 100% because I am lactose intolerant and also have IBS (irritable bowel syndrome), but I definitely do see a difference. I also feel more hungry than I was before I began the medicine. When I went in for my first follow up to see if the medicine level was correct, I told her that I feel more hungry through out the day. She said that since the medicine sort of speeds your body up, you are going to feel more hungry. (I explained to her the whole calorie counting thing) She told me to take my 3 meals and cut them in half and to eat them more often though out the day. She said not only will it help by making me feel not as hungry, but it will also help speed up my metabolism, which will help lose weight. I gave that a shot, and it helped. But also now that we have upped my level of Synthroid, the tummy issues are getting worse again. I've talked to a couple of friends that are also on Synthroid for hypothyroidism and they said that after you first few months, the weird tummy stuff goes away. It's just a new thing for your body and our body has a weird (and uncomfortable) way of getting used to it.

Hang in there!

Hi. I am debating taking the synthroid...I am borderline low thyroid...but with high antibodies low white blood cells, no period since 2011 (after having baby in 2012) sitll no period...am a bodybuilder and eat pretty clean. i went gf for a while and then back to gluten then the symptoms got worse...therefore believe gluten is an issue as well as dairy..still determining coffee and chocolate right now. I am struggling to cut more body fat and am hungry a lot of the time esp.at night. Any tips? What is this natural supplement you are talking about?

I was diagnosed with Hypothyroidism back in May. You must take the medication an hour before you eat OR three hours after eating (to ensure that your stomach is empty). You must take this medication on an EMPTY stomach for it to work its best.

I am taking Synthroid and I feel a lot better. I have more energy and I just feel more like "myself". I experienced terrible bloating and some puffiness just before I went on the medication - like bloating so bad I couldn't wear my normal clothes. I also maxed out at 157, but then the next day I was down to 155 and then I'd be back up again. I also gained 5 pounds that I lost in April, right before my diagnosis. So that was interesting, as I had obviously had Hypothyroidism coming my way for some months but I was able to lose some weight. My doctor thinks my miscarriage was the real catalyst for pushing it over the edge.

Now I have lost a few pounds, I'm down from 155. I've been eating 1,200 calories a day, and I'm trying to get more active. However, I really haven't done much by way of formal exercise (Pilates, running, walking, etc.). But I find I can get down to 150 fairly easily and quickly just by counting calories. We'll see if I can get back to my normal weight (140-145) this way though. I'm sure I'll need to do more by way of exercise.

I am hoping that the medication will help to take some of the weight off. I would love to be below 150 again. It's hard to know what weight was put on as a result of the Hypothyroidism. My doctor says that I should try to remember when I was feeling "healthy", and my weight then was "normal" weight. Meaning any weight gain up until that point could not be attributed to my thyroid.

I just wish I knew how much the medication could do for me, by way of losing weight. And would another drug work better?

Hi all!
I have been a MFP member for a while and lost about 30lbs. Then, out of no where, I had zero energy, my hair was falling out, I could hardly think. I had many people tell me "it must be your calories, you are not eathing enough" so I upped my calories. No change. I upped them again. No change. So I finally went to the doctor and turns out even though I lost weight, apparently I have hypothyroidism. She said she was suprised I lost any weight at all! (Trust me that weightloss was hard won!)

Now I have been on Synthroid (levothyroxine) for about 2 weeks. I have more energy and mental clarity, but unfortunately, I have stomach cramps and bloating to go wtih it, not to mention I am starving all the time. So, because of that-I have also gained back about 8-10lbs. I have lost all motivation to work out because my stomach hurts and I just dont think I can do this anymore.

Is there anyone out there who has hypothyroidism, who takes this med, and still loses weight?

I read that you shouldnt eat before a hour when you take the med, then I just read 3 hrs. Which is it? Are there certain foods I should/shouldnt be eating? I cant find anything on the net to help. So damn frustrated!!


Any help/words of wisdom would be appreciated.

I can on,y take the actual synthroid not the generic or it makes me nauseas, so that could be your problem as well.

I had my thyroid removed last December and since then I have gained 30 lbs. Ugh. I felt terrible on Synthroid only, although I don't attribute it to the synthroid. I attribute it to the possibility that my body wasn't converting T4 to T3 very effectively and the reason I believe that was the case is because in all my labs, my T4 was normal but my T3 was low. Anyway, I felt terrible- cold, hair loss, brain fog, dry skin, just the works. I asked my doctor to add Cytomel to my treatment in August and ever since then I have felt 100% better and my labs show it. My T4 and T3 are in the upper-normal range and my TSH is in the low-normal range and I am finally losing weight. Yay!

My goodness, I see a lot of misinformation in this thread!

There are many reasons why your thyroid (your largest endocrine gland) may not be able to produce enough T3 and T4. One of them occurs when your body begins to produce antibodies to your own thyroid, signalling your body to destroy it. This is an autoimmune disorder, and there is nothing that can be done, except to replace the hormones your thyroid is no longer able to produce in sufficient quantities to maintain health. Other people lose all or part of their thyroid to cancer, and need to be able to supply their body's with the T3 and T4 hormones by other means.

Levothyroxin, or 'synthroid' is a very effective treatment for underactive or absent thyroid. It should be taken at least 1/2 to 1 hour before a meal, first thing in the morning. It is generally well tolerated, and is a very safe and effective drug. I have been on it for 10 + years now, and have not had any problems. I get regularly tested for how my levels are doing, so the dosage can be increased if needed as time goes on.

When I was first diagnosed with Hashimoto's (the autoimmune disease) my hormone levels were very compromised, I had slowly put on five pounds despite being an avid runner, I was cold all the time and in a mental fog. Levothyroxine saved my life! I was able to lose those five lbs, and I felt like myself again.

Feel free to PM me if you have any questions. I can't say that I have experienced any side effects whatsoever, so those kinds of questions should be reserved for your doctor.

I also found out I was hypothyroid. While I didn't lose hair, I was really lethargic and depressed. They put me on a dosage of synthroid and it ended up being too high (turning me HYPERthyroid), which led to me being starving all the time (so I gained a lot of weight quickly because I couldn't stop eating) and my nails were breaking. It's hard to tell after being on a medication for only two weeks, but get a blood test done and see if you're hyperthyroid due to being overmedicated.

Also, I don't eat for an hour after taking my thyroid medication, which I take on an empty stomach.

Hi there...several years ago, I was having those same symptoms...I don't know which one was worse, the hair loss, or the forgetfulness!! Anyhow, after being tested, I was diagnosed with hypothyroidism and put on Synthroid and off I went. It should be noted...it takes about 6 weeks for your hormone levels to regulate, so, give it some time perhaps.

I had a very hard time with taking the medication...the words of my doctor kept running through my head, "once you start...your body will not be able to produce enough to regulate itself, so you will need to take this for the rest of your life........"
After losing a significant amount of weight, I was tested again, and my levels were ok. So...perhaps it's possible with diet and weightloss. I couldn't say for sure...I'm no professional.

Perhaps it was a risky chance...but I opted to try weighloss first to see if that would help before I put myself in a position to have to take a pill for the REST OF MY LIFE.

You being a nurse, I'm sure you will do what is best for you and your body. Best wishes to you.

Your levels were OK because your were taking synthroid. You levels should always be OK unless you need an increase in dose, that is why you get your levels checked. Have you gone off the thyroid meds now? And had your levels tested?

Oh for God's sake. Sucked in by another zombie thread!

Is there anyone out there who has hypothyroidism, who takes this med, and still loses weight?

I read that you shouldnt eat before a hour when you take the med, then I just read 3 hrs. Which is it? Are there certain foods I should/shouldnt be eating? I cant find anything on the net to help. So damn frustrated!!


Any help/words of wisdom would be appreciated.

My endo said not to eat anything for 1 hour and not to take any vitamins for 3 hours. Quick Question...are you drinking enough water when you take your synthroid? I do notice a difference when I drink a whole glass versus only drinking enough to get the pill down. I've been on Synthroid for 2 years...I've been at the same dose for about 9 months now. I am losing weight when I am eating at TDEE-20%. I would talk to your endo about your cramps and other symptoms.

Feel free to add me.

I've been on Levothyroxine for about 8 years. I used to have an overactive thyroid but it got SO overactive the doctor chemically shut it down with Methimizole and now it's underactive and over these 8 years I have gained 25 lbs. I workout about an hour 3X a week but don't lose weight. I just joined MFP today in hopes I'll lose this 25 lbs. Oh, I've been told grapefruit and grapefruit juice interferes with synthroid. I was told to wait 4 hours after taking my meds to eat or drink grapefruit.

Oh, I've been told grapefruit and grapefruit juice interferes with synthroid. I was told to wait 4 hours after taking my meds to eat or drink grapefruit.

From what I understand, the enzymes in grapefruit intensify a LOT of different medications.

I have taken levothyroxine for years since I had a thyroid ablation due to Grave's disease. I have taken up to 200mcg and I am currently at 175mcg per day and I can tell that their is an adjustment level with my alertness, fatigue and my appetite for several weeks afterward.

I sent a friend request..

I forgot to add, when I take my med... I take it at 5 AM... go back to sleep til my kids get up, usually 8-9. This has been working better.

You can't have anything but water up to an hour after taking it because it won't absorb properly. Also, avoid grapefruit and grapefruit juice because it interferes with absorption of the med.

I have been taking synthroid for just 10 days. This morning for the first time in years I sat up without feeling dizzy. This gives me hope. I set my alarm for 4:30 am and have my pill and water on my end table and go back to sleep. Although I only need 1/2 hour before eating, I like to start my day with a protein smoothy with almond milk and yogurt (calcium) and spinach (iron). My doctor told me I need at least 3 hours after I take synthroid before having either of these. This way I can have my smoothie and do my run at 7:30.
I have gained over 30 lbs in the last 9 years although I am a very healthy eater and I excersize everyday. I haven't lost any weight but I am hoping with my great eating habits and lots of exersize it will start