Run through the pain?

I would NOT run through any knee pain.
I would, however, go to a running store and have my stride evaluated and get a great pair of shoes. Then I would start slowly... walking more to build up my supporting muscles to be able to support my running pain free.

I would also check out some knee braces.

I would never run through pain. Running is the worst activity for your joints. If you can do different cardio exercises I would. In the end, running does a lot more harm than good to people.

My knees used to hurt after a workout also, as I got smaller the pain decreased. I would continue to workout, but do a less intensity, and build up to the harder stuff as you lose weight, the pressure on the knees can be intense. But for every pound you lose, it's 10 pounds of pressure off your knees.

I would never run through pain. Running is the worst activity for your joints. If you can do different cardio exercises I would. In the end, running does a lot more harm than good to people.

Running is actually good for your joints if you do it properly, as has been proven over and over and over again.

However, I do agree that no one shoud be running through actual PAIN, and especially not joint pain or bone pain. That's just setting yourself up for a serious injury. It's OK to run through muscles soreness or that feeling that your muscles have worked about as hard as they can. But not joint pain or bone pain.

OP should check with her doctor to be safe. And if OP has not been professionally fitted for running shoes, do that too. Some people can do some light running with 100 pounds to lose, but for many, that would cause to much stress to the joints and bones. So it may make sense to wait until you've lost a little more weight before doing regular running.

Look up the correct running technique online. If you are a heel striker you are putting your knees and hips at an increased risk of injury. Minor corrections and you will be good to go. Alternatively use good knee braces.

You should also consider your running route.

Is it pavement, asphault, dirt, grass....? Do you run on a crowned street, or any other surface that is curved from one side to the other? These can both be factors in joint pain. See if there are any improvements you can make to where/how you run.

I'm doing a similar running program and I'm a few years post-op from knee surgery.
When my knee starts hurting after/during a running workout, i drop back down a couple weeks in the program (something with more walking & less running) and try to help my knee build up strength that way. If you're too close to the beginning of the schedule, reduce the number of times the run/walk cycle is repeated.

Make sure you have proper fitted shoes. (I highly recommend finding a running store that has someone to fit you) They really make a difference.

Strength training may help. But if the problem is just that your knees are having trouble with the impact or running, you may need to start on softer surfaces and work your way to harder ones (like concrete)

I agree with everyone else. DO NOT RUN THROUGH the pain!! When I first started working out (really working out regularly and for an extended period of time) at the end of January, my knees bothered me as well. Mainly some soreness, not really pain. Since I started working out, I've actually lost less than 10 pounds (which, don't get me wrong, still contributed to the pain going away), but I've also been able to strengthen the muscles and ligaments surrounding my knees. This has helped immensely. I started running about 6 weeks into working out and now experience NO pain or even soreness at all. I say push yourself, but listen to your body. Pain isn't good, but you have to push a little bit further than you have before or you will not gain anything.

Good luck!