Has anyone else lose friends or family on this journey?

Do you mean because they're not supportive or because you don't have time?! I find its a little harder to balance work, fitness and my social life (beyond texting and social media ATM ) . but in terms of support, its been mixed. Ive actually gotten closer to those that are active themselves because we have so much to talk (and complain) about. But there has been some resistance to change from other close friends. What about you?

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I have very few close friends, but all of them plus my family are very supportive. If they are real friends they will be happy and supportive of your journey. They should want you to be happy and healthy.

Yuuuuup. Or not so much lost friends, as the nature of our relationship changed and we just had very little common ground and stopped hanging out. They get upset/frustrated with me wanting to talk macros and exercise routines and clean eating and I get upset/frustrated by the fact that every activity has to revolve around eating unhealthy junk food or drinking alcohol (which wouldn't necessarily be a problem, but apparently it's rude if I bring my own healthy food or refuse to drink/eat junk food). For now, I'm really just using MFP for support. My family has been the exception to the rule though- they may roll their eyes when I go on a rant about sugar substitutes, but they have been very supportive and encouraging. We definitely have engaged in some arguments with raised voices over my refusal to eat dessert and things at family holidays, but after time (about a year and a half), they realized my eating habits are not a fad and are really accepting and encouraging. They always stock my fav health foods when I get home from break now and have special salads they know I can eat that now accompany the holiday junk food buffet. I my family, lol.

Not me.

My social life has been somewhat modified. I've lost just shy of 50 pounds so far this year. I limit excessive nutrition and fitness discussions to one person (one I work-out with, one I talk nutrition with, one I talk weight lifting with). And we all get manic about that stuff every now and again, it's part of the process of being focused on it. But people don't want to hear about it. If they do, they will ask.

I still go out nearly as much as I used to. Some nights I don't drink. Some nights I don't eat. Some nights I skip lunch. When people ask me why I'm not drinking on a particular night, I say, "I'm trying to lose weight." For Friday happy hours after work, I hit the gym first. That saves me a drink or two, and I still have fun.

I am trying to make a lifestyle change. The easiest way for me to do that is not to abandon my previous one but change it just enough so that I can acheive a healthier weight.

@serra2009: The choice isn't between life of the party and party pooper. If you can find your happy medium, you'll stick with the changes for life.

I find it difficult to socialise because it often revolves around food and drink. Not all friendships stand the test of time. Perhaps it suits some people to have a fat friend.