Food That May Increase Lung Cancer Risks
GaleHawkins
Posts: 8,159 Member
todayupdates.net/are-carbs-the-new-cigarettes-white-bread-bagels-and-rice-increase-the-risk-of-lung-cancer-by-49-experts-warn/
Never heard of this risk of lung cancer before but will try to find more supporting/refuting evidence going forward.
Never heard of this risk of lung cancer before but will try to find more supporting/refuting evidence going forward.
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Replies
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I didn't see the study linked, so I did a search for one of the researchers. Just one of them has studies linking meat to kidney cancer, fats to colon cancer, ketogenic diets to brain cancer, and the use of fertilizers to skin cancer.0
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Ok so...... living=cancer.
Pass me the butter for my white bread please!0 -
Good point usmcmp.
https://mdanderson.org/newsroom/2016/03/dietary-glycemic-ind.html
"This research, published this week in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, represents the largest study to investigate potential links between glycemic index (GI) and lung cancer. "
From this from MD Anderson it must be just published recently.0 -
GaleHawkins wrote: »Good point usmcmp.
https://mdanderson.org/newsroom/2016/03/dietary-glycemic-ind.html
"This research, published this week in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, represents the largest study to investigate potential links between glycemic index (GI) and lung cancer. "
From this from MD Anderson it must be just published recently.
Id be interested in reading the study for sure.
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cebp.aacrjournals.org/gca?submit=Get+All+Checked+Abstracts&gca=cebp%3B25%2F3%2F532
It seems to have been submitted for publication in mid 2015 per the abstract below.
Selected Abstracts
Abstract 1
Research Articles:
Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites
Stephanie C. Melkonian, Carrie R. Daniel, Yuanqing Ye, Jeanne A. Pierzynski, Jack A. Roth, and Xifeng Wu
Cancer Epidemiol Biomarkers Prev March 2016 25:532-539; doi:10.1158/1055-9965.EPI-15-0765
Abstract Full Text Full Text (PDF) Figures Only
Abstract 1 of 1
Research Articles
Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites
Background: Postprandial glucose (PPG) and insulin responses play a role in carcinogenesis. We evaluated the association between dietary glycemic index (GI) and glycemic load (GL), markers of carbohydrate intake and PPG, and lung cancer risk in non-Hispanic whites.
Methods: GL and GI were assessed among 1,905 newly diagnosed lung cancer cases recruited from the University of Texas MD Anderson Cancer Center (Houston, TX) and 2,413 healthy controls recruited at Kelsey-Seybold Clinics (Houston, TX). We assessed associations between quintiles of GI/GL and lung cancer risk and effect modification by various risk factors. ORs and 95% confidence intervals (CI) were estimated using multivariable logistic regression.
Results: We observed a significant association between GI [5th vs. 1st quintile (Q) OR = 1.49; 95% CI, 1.21–1.83; Ptrend <0.001] and lung cancer risk and GIac (5th vs. 1st Q OR = 1.48; 95% CI, 1.20–1.81; Ptrend = 0.001) and lung cancer risk. We observed a more pronounced association between GI and lung cancer risk among never smokers (5th vs. 1st Q OR = 2.25; 95% CI, 1.42–3.57), squamous cell carcinomas (SCC; 5th vs. 1st Q OR = 1.92; 95% CI, 1.30–2.83), and those with less than 12 years of education (5th vs. 1st Q OR = 1.75; 95% CI, 1.19–2.58, Pinteraction = 0.02).
Conclusion: This study suggests that dietary GI and other lung cancer risk factors may jointly and independently influence lung cancer etiology.
Impact: Understanding the role of GI in lung cancer could inform prevention strategies and elucidate biologic pathways related to lung cancer risk. Cancer Epidemiol Biomarkers Prev; 25(3); 532–9. ©2016 AACR.
Received July 13, 2015.0 -
When they first studied associations with lung cancer links before it was seen as a given that one of the primary causes was smoking, they found a huge association between coffee consumption and lung cancer. The thing is, that was only a correlation, not a causation. People who smoked also drank a lot of coffee. I think studies like this have some value, but only in terms of looking for areas of further study.0
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Here is a link to the abstract. It looks like you need to buy a subscription to view the entire text.
http://cebp.aacrjournals.org/content/25/3/532.abstract0 -
The study seems rather iffy since it relies on subject recall for food and then calculating GI and GL from that:We used a modified version of the NCI Health Habits and History Questionnaire (29). The questionnaire includes a semiquantitative food frequency list made up of food and beverage items and an open-ended section regarding dietary behaviors such as dining in restaurants and food preparation methods. Portion size was also queried. Total energy intake, total carbohydrate intake, total fiber intake, and grams per day of consumption for each food item were estimated using the USDA Food and Nutrient Database for Dietary Studies (30). Total meat intake was calculated by adding total grams per day of each meat item in the food frequency questionnaire (FFQ). All nutrient and food variables of interest were energy adjusted for total caloric intake using the residual method (31).
In addition, glycemic load was not associated with cancer in any model; it makes no sense that GI would affect cancer but GL would not. Unless it's just a correlation and not a cause. Oh wait...
My other favorite conclusion:This is only the second study to suggest an independent association between GI and lung cancer risk and the first study to suggest that GI may influence lung cancer risk more profoundly in specific subgroups, including never smokers, individuals with low levels of education (<12 years), and those diagnosed with certain histologic subtypes of lung cancer, specifically SCC.
Your glycemic index knows how much schooling you've had. It's one of the reasons why a lot of correlation studies don't make sense when you step back and look at them. And I'm very disappointed that the discussion never even addressed by GI was correlated and GL was not. It goes into a lot of detail on how spikes in insulin can lead to all sorts of issues, but GL has been shown to be more relevant to spikes in insulin than GI.
Much disappoint.0 -
I wonder if it could be the higher antioxidant content of low glycemic carbs like vegetables and berries that accounts for the difference? Several phytochemicals are showing possible protective effects against cancer, and a diet high in processed carbs would have fewer sources of phytochemicals.
I do believe that lifestyle and nutrition affect cancer risk (after reading the American Institute for Cancer Research report and recommendations), but I think that often news articles exaggerate the risk by not giving the baseline risk for the general population. The incidence of lung cancer in non smokers aged 50-59 between 1982 and 2000, for example, was under 10 per 100,000
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170525/#!po=7.82209
I don't think that the prospect of raising one's risk from 1 in 10,000 (0.01%) to 1.5 in 10,000 (0.015%) sounds nearly as alarming as the headline of the article. Carbs are definitely not the new cigarettes, and it's alarmist headlines like this that make people start to doubt the science, or throw their hands up and say "well, everything gives you cancer, so why bother trying?"0 -
Need2Exerc1se wrote: »Here is a link to the abstract. It looks like you need to buy a subscription to view the entire text.
http://cebp.aacrjournals.org/content/25/3/532.abstract
I think they wanted $35 for the full research paper.
The link from MD Anderson (re posted below) does give more facts of the study but it would be nice to have the complete study. As @rileysowner states its main value is to encourage further study.
https://mdanderson.org/newsroom/2016/03/dietary-glycemic-ind.html0 -
yay...fear mongering...my favorite.0
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The study seems rather iffy since it relies on subject recall for food and then calculating GI and GL from that:We used a modified version of the NCI Health Habits and History Questionnaire (29). The questionnaire includes a semiquantitative food frequency list made up of food and beverage items and an open-ended section regarding dietary behaviors such as dining in restaurants and food preparation methods. Portion size was also queried. Total energy intake, total carbohydrate intake, total fiber intake, and grams per day of consumption for each food item were estimated using the USDA Food and Nutrient Database for Dietary Studies (30). Total meat intake was calculated by adding total grams per day of each meat item in the food frequency questionnaire (FFQ). All nutrient and food variables of interest were energy adjusted for total caloric intake using the residual method (31).
In addition, glycemic load was not associated with cancer in any model; it makes no sense that GI would affect cancer but GL would not. Unless it's just a correlation and not a cause. Oh wait...
My other favorite conclusion:This is only the second study to suggest an independent association between GI and lung cancer risk and the first study to suggest that GI may influence lung cancer risk more profoundly in specific subgroups, including never smokers, individuals with low levels of education (<12 years), and those diagnosed with certain histologic subtypes of lung cancer, specifically SCC.
Your glycemic index knows how much schooling you've had. It's one of the reasons why a lot of correlation studies don't make sense when you step back and look at them. And I'm very disappointed that the discussion never even addressed by GI was correlated and GL was not. It goes into a lot of detail on how spikes in insulin can lead to all sorts of issues, but GL has been shown to be more relevant to spikes in insulin than GI.
Much disappoint.
@auddii i think we all can agree one's glycemic index does not know how much schooling one has.
The below from the MD Anderson link covers points that could make you less disappointed in the study.
"Among those with fewer than 12 years of education, subjects in the highest GI group were 77 percent more likely to develop lung cancer than those in the lowest GI group. This contrasts with an elevated risk of only 33 percent in subjects with more than 12 years of education.
The authors note that educational level is a proxy for socioeconomic status, which has been linked with diet quality and smoking behaviors. Thus, the associations between GI and education may reflect the joint impact of poor diet and smoking on lung cancer risk.
The authors note several limitations to the study, including being limited to non-Hispanic whites. Further, this was a retrospective study, subject to errors in recall of past dietary intake, and the study did not account for diabetes, hypertension or heart disease in their subjects."0 -
Sugar/carbs - yep, no mystery here! Cancer love the stuff!0
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GaleHawkins wrote: »Need2Exerc1se wrote: »Here is a link to the abstract. It looks like you need to buy a subscription to view the entire text.
http://cebp.aacrjournals.org/content/25/3/532.abstract
I think they wanted $35 for the full research paper.
The link from MD Anderson (re posted below) does give more facts of the study but it would be nice to have the complete study. As @rileysowner states its main value is to encourage further study.
https://mdanderson.org/newsroom/2016/03/dietary-glycemic-ind.html
Sadly, that "more research" line very much is ignored by the media, and frustratingly by a seemly growing (although possibly only very vocal) number of researchers who have an agenda to promote.0 -
MakePeasNotWar wrote: »I wonder if it could be the higher antioxidant content of low glycemic carbs like vegetables and berries that accounts for the difference? Several phytochemicals are showing possible protective effects against cancer, and a diet high in processed carbs would have fewer sources of phytochemicals.
I do believe that lifestyle and nutrition affect cancer risk (after reading the American Institute for Cancer Research report and recommendations), but I think that often news articles exaggerate the risk by not giving the baseline risk for the general population. The incidence of lung cancer in non smokers aged 50-59 between 1982 and 2000, for example, was under 10 per 100,000
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170525/#!po=7.82209
I don't think that the prospect of raising one's risk from 1 in 10,000 (0.01%) to 1.5 in 10,000 (0.015%) sounds nearly as alarming as the headline of the article. Carbs are definitely not the new cigarettes, and it's alarmist headlines like this that make people start to doubt the science, or throw their hands up and say "well, everything gives you cancer, so why bother trying?"
@MakePeasNotWar I think you are on to something perhaps. The statement from the MD Anderson site, "Interestingly, GL had no significant associations with lung cancer risk. “This suggests that it is the average quality, instead of quantity, of carbohydrates consumed that may modulate lung cancer risk,” said Wu." drives home the "quality" of the carbs may more of a factor in causing cancer than the "quantity" of carbs.
ALL ABOUT THE GLYCEMIC INDEX
The glycemic index, or GI, measures how a carbohydrate-containing food raises blood glucose.
Foods are ranked based on how they compare to a reference food — either glucose or white bread.
A food with a high GI raises blood glucose more than a food with a medium or low GI.
The below is from the first link in this thread. Vegs made the low GI list for sure.
Foods with low GI include
:
100% stone-ground whole wheat or pumpernickel bread
Oatmeal (rolled or steel-cut), oat bran, muesli
Wholemeal pasta, converted rice, barley, bulgar wheat
Sweet potato, corn, yam, lima/butter beans, peas, legumes and lentils
Foods with high GI include:
White bread or bagel
Corn flakes, puffed rice, bran flakes, instant oatmeal
Shortgrain white rice, rice pasta, macaroni and cheese from mix
Russet potato, pumpkin
Pretzels, rice cakes, popcorn, saltine crackers
melons and pineapple
Source: American Diabetes Association0 -
GaleHawkins wrote: »todayupdates.net/are-carbs-the-new-cigarettes-white-bread-bagels-and-rice-increase-the-risk-of-lung-cancer-by-49-experts-warn/
Never heard of this risk of lung cancer before but will try to find more supporting/refuting evidence going forward.
Guess I better stop smoking my bagels.0 -
I'd think anything inhaled would more directly affect the lungs. The Canadian Medical Association agrees.
http://news.nationalpost.com/health/doctors-say-canadians-should-not-smoke-any-plant-material-including-marijuana0 -
htimpaired wrote: »GaleHawkins wrote: »todayupdates.net/are-carbs-the-new-cigarettes-white-bread-bagels-and-rice-increase-the-risk-of-lung-cancer-by-49-experts-warn/
Never heard of this risk of lung cancer before but will try to find more supporting/refuting evidence going forward.
Guess I better stop smoking my bagels.
Based on GI only smoking sweet potatoes may be safer. Well maybe not based on what @jgnatca just posted.
The bottom line we know cancer needs glucose to be able to grow fast and spread so the Glycemic Index of foods could be a factor leading to cancer is not hard to grasp. I expect more studies will come. I try to eat to mainly live on ketones instead of glucose to manage my joint and muscle pain without Rx meds but I am the only one in my family that is not living on mainly carbs now.0 -
GaleHawkins wrote: »MakePeasNotWar wrote: »I wonder if it could be the higher antioxidant content of low glycemic carbs like vegetables and berries that accounts for the difference? Several phytochemicals are showing possible protective effects against cancer, and a diet high in processed carbs would have fewer sources of phytochemicals.
I do believe that lifestyle and nutrition affect cancer risk (after reading the American Institute for Cancer Research report and recommendations), but I think that often news articles exaggerate the risk by not giving the baseline risk for the general population. The incidence of lung cancer in non smokers aged 50-59 between 1982 and 2000, for example, was under 10 per 100,000
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170525/#!po=7.82209
I don't think that the prospect of raising one's risk from 1 in 10,000 (0.01%) to 1.5 in 10,000 (0.015%) sounds nearly as alarming as the headline of the article. Carbs are definitely not the new cigarettes, and it's alarmist headlines like this that make people start to doubt the science, or throw their hands up and say "well, everything gives you cancer, so why bother trying?"
@MakePeasNotWar I think you are on to something perhaps. The statement from the MD Anderson site, "Interestingly, GL had no significant associations with lung cancer risk. “This suggests that it is the average quality, instead of quantity, of carbohydrates consumed that may modulate lung cancer risk,” said Wu." drives home the "quality" of the carbs may more of a factor in causing cancer than the "quantity" of carbs.
ALL ABOUT THE GLYCEMIC INDEX
The glycemic index, or GI, measures how a carbohydrate-containing food raises blood glucose.
Foods are ranked based on how they compare to a reference food — either glucose or white bread.
A food with a high GI raises blood glucose more than a food with a medium or low GI.
The below is from the first link in this thread. Vegs made the low GI list for sure.
Foods with low GI include
:
100% stone-ground whole wheat or pumpernickel bread
Oatmeal (rolled or steel-cut), oat bran, muesli
Wholemeal pasta, converted rice, barley, bulgar wheat
Sweet potato, corn, yam, lima/butter beans, peas, legumes and lentils
Foods with high GI include:
White bread or bagel
Corn flakes, puffed rice, bran flakes, instant oatmeal
Shortgrain white rice, rice pasta, macaroni and cheese from mix
Russet potato, pumpkin
Pretzels, rice cakes, popcorn, saltine crackers
melons and pineapple
Source: American Diabetes Association
Except that glycemic load looks at the overall effect of the food on glucose, not just the carbohydrate. So some foods with high GI don't actually raise blood sugar levels, and so are considered to have a low glycemic load. This is especially apparent when looking at the glycemic load of a meal as opposed to one particular food in in that meal. You can't theorize that the elevation in blood sugar is what leads to the increase risk of cancer if the blood sugar levels aren't actually spiking.0 -
I'm skeptical that you can really link GI and any causal effect here, especially since they seem to be focusing on the GI of the foods consumed, and not the actual combinations or effect on blood sugar.
More likely, diets that are overall high in GI tend to be less healthy diets in general, and eaten by people who don't eat lots of vegetables (which tend to have positive correlations with health).
That's consistent with the fact that there's also a correlation here with foods that wouldn't be high GI:Diets high in fruits and vegetables may decrease risk, while increased consumption of red meat, saturated fats and dairy products have been shown to increase lung cancer risk.
https://www.mdanderson.org/newsroom/2016/03/dietary-glycemic-ind.html
Interesting in that fruit is often high GI, but not high GL.0 -
To GaleHawkins……..this thread has me very upset. I thought this was a support group, not a medical science group..0
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Like most retrospective cohort studies, it's interesting in that it could suggest further avenues of research, but by itself it's effectively meaningless, particularly with something as incredibly complex as cancer biology. There are so many confounding variables it's impossible to control for them all, particularly because there tend to be incredible numbers of correlations among the various things that form one's lifestyle, and many of those will correlate with cancer.
Occupation and radon exposure are two large risk factors for lung cancer, and neither was controlled here.
And of course this suffers the same effect as most science reporting: "A may be correlated with B" transforms into "A definitely causes B" when it reaches mass media.0 -
This content has been removed.
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rankinsect wrote: »Like most retrospective cohort studies, it's interesting in that it could suggest further avenues of research, but by itself it's effectively meaningless, particularly with something as incredibly complex as cancer biology. There are so many confounding variables it's impossible to control for them all, particularly because there tend to be incredible numbers of correlations among the various things that form one's lifestyle, and many of those will correlate with cancer.
Occupation and radon exposure are two large risk factors for lung cancer, and neither was controlled here.
And of course this suffers the same effect as most science reporting: "A may be correlated with B" transforms into "A definitely causes B" when it reaches mass media.
However it is a good way for a center to get more money to do more studies and there is beg money in research. The cancer patients I work with have both smoking and crappy diet. I have seen very few non smokers have cancer but those that do may have other environmental risk factors.0 -
They say they accounted for smoking, but I wonder if that is smoking tobacco only. I'd be curious to know how many smoked other things that often go hand in hand with eating lots of low GI foods.0
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Need2Exerc1se wrote: »They say they accounted for smoking, but I wonder if that is smoking tobacco only. I'd be curious to know how many smoked other things that often go hand in hand with eating lots of low GI foods.
Great point!!!!0 -
The study seems rather iffy since it relies on subject recall for food and then calculating GI and GL from that:We used a modified version of the NCI Health Habits and History Questionnaire (29). The questionnaire includes a semiquantitative food frequency list made up of food and beverage items and an open-ended section regarding dietary behaviors such as dining in restaurants and food preparation methods. Portion size was also queried. Total energy intake, total carbohydrate intake, total fiber intake, and grams per day of consumption for each food item were estimated using the USDA Food and Nutrient Database for Dietary Studies (30). Total meat intake was calculated by adding total grams per day of each meat item in the food frequency questionnaire (FFQ). All nutrient and food variables of interest were energy adjusted for total caloric intake using the residual method (31).
In addition, glycemic load was not associated with cancer in any model; it makes no sense that GI would affect cancer but GL would not. Unless it's just a correlation and not a cause. Oh wait...
My other favorite conclusion:This is only the second study to suggest an independent association between GI and lung cancer risk and the first study to suggest that GI may influence lung cancer risk more profoundly in specific subgroups, including never smokers, individuals with low levels of education (<12 years), and those diagnosed with certain histologic subtypes of lung cancer, specifically SCC.
Your glycemic index knows how much schooling you've had. It's one of the reasons why a lot of correlation studies don't make sense when you step back and look at them. And I'm very disappointed that the discussion never even addressed by GI was correlated and GL was not. It goes into a lot of detail on how spikes in insulin can lead to all sorts of issues, but GL has been shown to be more relevant to spikes in insulin than GI.
Much disappoint.
I protect myself by quickly forgetting all food I've eaten moments after I've eaten it. I assume any cancer cells in my body will also learn this habit, and thus fail to proliferate.0 -
MommyMeggo wrote: »Ok so...... living=cancer.
Pass me the butter for my white bread please!
Thanks for the laugh, even though I do not eat white bread, that was funny. Butter any day over that artificial crap that called : I can't believe it's not butter - who eats that.0 -
The study seems rather iffy since it relies on subject recall for food and then calculating GI and GL from that:We used a modified version of the NCI Health Habits and History Questionnaire (29). The questionnaire includes a semiquantitative food frequency list made up of food and beverage items and an open-ended section regarding dietary behaviors such as dining in restaurants and food preparation methods. Portion size was also queried. Total energy intake, total carbohydrate intake, total fiber intake, and grams per day of consumption for each food item were estimated using the USDA Food and Nutrient Database for Dietary Studies (30). Total meat intake was calculated by adding total grams per day of each meat item in the food frequency questionnaire (FFQ). All nutrient and food variables of interest were energy adjusted for total caloric intake using the residual method (31).
In addition, glycemic load was not associated with cancer in any model; it makes no sense that GI would affect cancer but GL would not. Unless it's just a correlation and not a cause. Oh wait...
My other favorite conclusion:This is only the second study to suggest an independent association between GI and lung cancer risk and the first study to suggest that GI may influence lung cancer risk more profoundly in specific subgroups, including never smokers, individuals with low levels of education (<12 years), and those diagnosed with certain histologic subtypes of lung cancer, specifically SCC.
Your glycemic index knows how much schooling you've had. It's one of the reasons why a lot of correlation studies don't make sense when you step back and look at them. And I'm very disappointed that the discussion never even addressed by GI was correlated and GL was not. It goes into a lot of detail on how spikes in insulin can lead to all sorts of issues, but GL has been shown to be more relevant to spikes in insulin than GI.
Much disappoint.
I protect myself by quickly forgetting all food I've eaten moments after I've eaten it. I assume any cancer cells in my body will also learn this habit, and thus fail to proliferate.
I must try this, makes sense to me0 -
Pinkylee77 wrote: »The study seems rather iffy since it relies on subject recall for food and then calculating GI and GL from that:We used a modified version of the NCI Health Habits and History Questionnaire (29). The questionnaire includes a semiquantitative food frequency list made up of food and beverage items and an open-ended section regarding dietary behaviors such as dining in restaurants and food preparation methods. Portion size was also queried. Total energy intake, total carbohydrate intake, total fiber intake, and grams per day of consumption for each food item were estimated using the USDA Food and Nutrient Database for Dietary Studies (30). Total meat intake was calculated by adding total grams per day of each meat item in the food frequency questionnaire (FFQ). All nutrient and food variables of interest were energy adjusted for total caloric intake using the residual method (31).
In addition, glycemic load was not associated with cancer in any model; it makes no sense that GI would affect cancer but GL would not. Unless it's just a correlation and not a cause. Oh wait...
My other favorite conclusion:This is only the second study to suggest an independent association between GI and lung cancer risk and the first study to suggest that GI may influence lung cancer risk more profoundly in specific subgroups, including never smokers, individuals with low levels of education (<12 years), and those diagnosed with certain histologic subtypes of lung cancer, specifically SCC.
Your glycemic index knows how much schooling you've had. It's one of the reasons why a lot of correlation studies don't make sense when you step back and look at them. And I'm very disappointed that the discussion never even addressed by GI was correlated and GL was not. It goes into a lot of detail on how spikes in insulin can lead to all sorts of issues, but GL has been shown to be more relevant to spikes in insulin than GI.
Much disappoint.
I protect myself by quickly forgetting all food I've eaten moments after I've eaten it. I assume any cancer cells in my body will also learn this habit, and thus fail to proliferate.
I must try this, makes sense to me
Yeah. Only, I'm hungry now. I don't remember when I last ate, it must have been a while ago.0
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