Reaction to artificial sweeteners?

Short answer: yes.

Slightly Longer Answer: It might be worth your while, if you're committed to eating artificial sweeteners (AS), to take note of what sweetener you're eating and how you feel afterwards. For example, I can eat stevia OK, but too much sucralose turns my digestive tract to mush.
There are some folks out there that would advise to not eat AS at all, but that can be difficult, especially with protein supplements.

I choose not to use AS for health reasons. I can do stevia and xylitol. I far prefer xylitol. I like oocdc2's suggestion though for testing out which ones you have a problem with physically. You might find yourself okay with things like stevia and/or xylitol.

I try not to eat anything with artificial sweetners, I use natural sweetners. I would get bloated and have a stomach ache when I use them.

Aspartame gives me a headache. I don't like the taste/aftertaste of one of the others but I don't remember which one anymore because I've avoided all of them for so long since they started mixing them together that it doesn't really matter. I used to be able to use some things that have artificial sweetener but the mixing took care of that.

Now I just buy the non-sugarfree versions of things and use a packet of Sugar in the Raw (because I like the flavor) whenever I want to add a little sweetener.