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Could rapid weight loss being healthier sometimes?

Posts: 1,207 Member
edited December 2024 in Debate Club
So this thought has started to fester after listening to Diabetes Researcher Nicola Guess discuss the The Diabetes Remission Clinical Trial (DiRECT) study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754868/
In it, roughly half of people that lost 15kg or more in a few months put their Type 2 Diabetes into remission, meaning they no longer needed to use any of their medications. That's pretty incredible.
Of note, Dr. Guess pointed out that this result is not seen merely by losing 15kg, but only seems to show up when the weight loss is rather quick. It seems that the protocols necessary to cause it involve very low calorie diets - 900 calories a day. Obviously these are levels that should only be done with some kind of medical support. Yet it also seems concerning if the general tendency in the public's mind is to shun rapid weight loss and have stories out their about damaging metabolism if, in fact, it the way to treat diabetes, a disease that threatens to topple the health system at the rate it is growing globally.

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  • Posts: 7,887 Member
    edited August 2019
    Of note, Dr. Guess pointed out that this result is not seen merely by losing 15kg, but only seems to show up when the weight loss is rather quick. It seems that the protocols necessary to cause it involve very low calorie diets - 900 calories a day. Obviously these are levels that should only be done with some kind of medical support. Yet it also seems concerning if the general tendency in the public's mind is to shun rapid weight loss and have stories out their about damaging metabolism if, in fact, it the way to treat diabetes, a disease that threatens to topple the health system at the rate it is growing globally.

    This is interesting, and I wonder what the mechanism is. (I noticed that she's on SigmaNutrition as I subscribe to that podcast but am always behind, so will have to listen to it.)

    It does seem consistent with the fact that WLS seems to address T2D very effectively and quickly.

    I'm not as down on rapid weight loss as some here. I think there's something to be said for slow and steady allowing more time for changing habits (but if you have a lot to lose you can start with a fast loss and then transition to slower).

    I do think unsupervised 900 cal would be a dangerous thing for people to assume they should aspire to, as it's so easy to not get adequate nutrition, and unfortunately there's so often a tendency that if something is good for specific purposes people decide it might be a good choice for others (like vanity weight loss). See the various posts from people asking about following the pre WLS diet unsupervised and without intending to get WLS, because it must be safe if those other people do it.
  • Posts: 1,207 Member
    lemurcat2 wrote: »

    This is interesting, and I wonder what the mechanism is. (I noticed that she's on SigmaNutrition as I subscribe to that podcast but am always behind, so will have to listen to it.)

    It does seem consistent with the fact that WLS seems to address T2D very effectively and quickly.

    I'm not as down on rapid weight loss as some here. I think there's something to be said for slow and steady allowing more time for changing habits (but if you have a lot to lose you can start with a fast loss and then transition to slower).

    I do think unsupervised 900 cal would be a dangerous thing for people to assume they should aspire to, as it's so easy to not get adequate nutrition, and unfortunately there's so often a tendency that if something is good for specific purposes people decide it might be a good choice for others (like vanity weight loss). See the various posts from people asking about following the pre WLS diet unsupervised and without intending to get WLS, because it must be safe if those other people do it.

    WLS is actually the impetus behind the study. The pre WLS involves a liver reducing diet to make the surgery safer, and it was wondered if the diet prep for WLS and immediately following it induce the changes, rather than the surgery itself.
  • Posts: 1,207 Member
    There is indeed such a thing as adult onset type 1. It’s sometimes called LADA. It’s not nearly as common as adult onset type 2, but it does happen, in a similar way to child onset type 1, through an autoimmune attack. However, it is distinguished from type 2 by weight loss, metformin and similar meds, and dietary changes having no effect on it. The usual course of lada is for it to be misdiagnosed as type 2 initially, then later when the person does not respond to the usual type 2 protocol and gets very ill, they are correctly diagnosed and put on insulin.

    There is no form of type 1 which can be helped by losing weight and eating better.

    I will argue semantics as important here and say no. There is type 1 diabetes that can happen when an adult - or could onset when an adult, but calling it Type 1 adult onset is bad terminology because it sounds like it is referencing type 2. That's why it is typically called LADA, also Type 1 in Adults, Adult-Onset Atypical Type 1 Diabetes, or Late Onset Type 1.
    As for the rest, yeah type 1 is a very different pathology from type 2. Frankly, I'm not sure type 2 is a monolithic disease itself - there's some differences in people having the insulin insensitivity in their liver versus in the muscle cells.
    Also agreed about the things unlikely to alter the course of T1D as an autoimmune disease. I suppose technically some people do follow diets to alleviate autoimmune symptoms, but I don't think that could truly halt the process going on in T1D.
  • Posts: 23 Member
    Please explain what adult onset type I diabetes is ?
  • Posts: 23 Member
    After reading all the threads it all makes sense and Web MD gives a pretty good explanation aswell.
  • Posts: 2 Member
    Low carb diets can help type 1 diabetics control their illness. It will not cure it.
  • Posts: 10,330 Member
    Did they mention how long the remission lasted after transitioning to maintenance or is it still not determined?
  • Posts: 1,207 Member
    Did they mention how long the remission lasted after transitioning to maintenance or is it still not determined?

    It is ongoing. They're releasing follow up data annually. While not in the particular study, I would suppose the longest lasting remission would be someone who had WLS that induced it.
  • Posts: 6,252 Member
    I'm concerned with the level of confirmation bias involved as there is a clear desire for the outcome to be true rather than a careful review of the data and accepting a best course of action.

    The design of experiment biases the outcome. Much of this notion of damaging metabolism is originating from the WLS industry.
  • Posts: 1,207 Member
    CSARdiver wrote: »
    I'm concerned with the level of confirmation bias involved as there is a clear desire for the outcome to be true rather than a careful review of the data and accepting a best course of action.

    The design of experiment biases the outcome. Much of this notion of damaging metabolism is originating from the WLS industry.

    Could you explain how so? In what way would you change either the experiment's procedures or measured outcomes to reduce or eliminate the biase?
  • Posts: 6,252 Member

    Could you explain how so? In what way would you change either the experiment's procedures or measured outcomes to reduce or eliminate the biase?

    The design only evaluated those under medical supervision and an extreme low calorie diet. To evaluate the impact you need a control group and an second evaluation group - such as one following the MFP plan of 1-2lb/week rate.

    This design also does not take in to account the long term impact. Considering weight is an output of behavior is there a focus on changing behavior?

    I imagine the immediate concern is to mitigate a greater risk, such as morbidly obese patients.
  • Posts: 10,131 Member
    I'm a little confused. The article linked in the OP is from 2016 and appears to be discussing the methodology for the planned DiRECT study, whose results were expected to be available beginning in 2018. What were the results?

    Also, the linked article included a plan for returning patients in the intervention cohort to the VLCD if they regained weight OR if a1c measurement returns to diabetic range (search the article for "rescue plans" to find what I'm talking about). To me that, combined with the relatively short term of the study, should invalidate those subjects -- you couldn't really draw valid conclusions on whether their diabetic was reversed because of the weight loss or because they were in a steep deficit. The somewhat ambiguous description of the previous Counterpoint study ("Results showed a mean weight loss of 15.3 kg and a rapid return of fasting blood glucose to normal, which persisted for up to 3 months after return to normal diet." - emphasis added) also leaves room for the diabetic reversal to be attributed to the state of being in a steep deficit (600 kcal/day) rather than the actual weight loss.

    What's wanted is a study to see if two, three, five years after returning to a maintenance diet, the subjects still have a healthy a1c.
  • Posts: 1,207 Member
    CSARdiver wrote: »

    The design only evaluated those under medical supervision and an extreme low calorie diet. To evaluate the impact you need a control group and an second evaluation group - such as one following the MFP plan of 1-2lb/week rate.

    This design also does not take in to account the long term impact. Considering weight is an output of behavior is there a focus on changing behavior?

    I imagine the immediate concern is to mitigate a greater risk, such as morbidly obese patients.

    There was a control group - those kept under the normal Diabetic Care Guidelines. I don't think you're suggesting a control group removed from standard guidance as that would be medically unethical.

    Why does the study need to evaluate changing behavior when the point of the study isn't "can we sustain weight loss", the study is designed to see "does rapid weight loss induce T2D remission?" It does include counseling to maintain the weight loss post low calorie diet, as maintaining the weight loss is one goal of the study - to see if the remission lasts when weight loss is maintained.

    The concern of the study is evaluating is rapid weight loss a method to induce T2D remission. T2D is a rather big deal in terms of projected medical costs.
  • Posts: 1,207 Member
    I'm a little confused. The article linked in the OP is from 2016 and appears to be discussing the methodology for the planned DiRECT study, whose results were expected to be available beginning in 2018. What were the results?

    Also, the linked article included a plan for returning patients in the intervention cohort to the VLCD if they regained weight OR if a1c measurement returns to diabetic range (search the article for "rescue plans" to find what I'm talking about). To me that, combined with the relatively short term of the study, should invalidate those subjects -- you couldn't really draw valid conclusions on whether their diabetic was reversed because of the weight loss or because they were in a steep deficit. The somewhat ambiguous description of the previous Counterpoint study ("Results showed a mean weight loss of 15.3 kg and a rapid return of fasting blood glucose to normal, which persisted for up to 3 months after return to normal diet." - emphasis added) also leaves room for the diabetic reversal to be attributed to the state of being in a steep deficit (600 kcal/day) rather than the actual weight loss.

    What's wanted is a study to see if two, three, five years after returning to a maintenance diet, the subjects still have a healthy a1c.

    The two year results study:
    https://www.ncbi.nlm.nih.gov/pubmed/30852132
  • Posts: 10,131 Member

    The two year results study:
    https://www.ncbi.nlm.nih.gov/pubmed/30852132

    Thanks. Too late to read it now, but I'll try to remember tomorrow.
This discussion has been closed.