Gluten sensitive / non-coeliac controversy grinds on

yarwell

Another study - http://www.ncbi.nlm.nih.gov/pubmed/25701700 - crossover RCT of 59 patients "In a cross-over trial of subjects with suspected NCGS, the severity of overall symptoms increased significantly during 1 week of intake of small amounts of gluten, compared with placebo. Clinical trial no: ISRCTN72857280."

According to the per-protocol analysis of data from the 59 patients who completed the trial, intake of gluten significantly increased overall symptoms compared with placebo (P=.034). Abdominal bloating (P=.040) and pain (P=.047), among the intestinal symptoms, and foggy mind (P=.019), depression (P=.020), and aphthous stomatitis (P=.025), among the extra-intestinal symptoms, were significantly more severe when subjects received gluten than placebo.

Contrasts with http://www.ncbi.nlm.nih.gov/pubmed/23648697 with a slightly smaller sample that found little gluten-specific effects after eliminating other cofounders.