Uric acid - Uricase enzyme mutation - Fructose - Diabetes - Obesity and the Hunt for the Fat Gene

andrikosDE

So among all the podcasts I listen to daily during my commute, this one made me stop, think and give it a second listen.

http://www.scientificamerican.com/podcast/episode/the-hunt-for-the-fat-gene/

If you have time to listen to it, I have a feeling you'll be as blown away as I was...

It refers to this article (requires subscription)
http://www.scientificamerican.com/article/ancient-mutation-in-apes-may-explain-human-obesity-and-diabetes/

But to hear it from the professor himself describing his investigation over the decades is truly fascinating.

If you have time, please give it a listen, it's about 30 minutes long.

yarwell

I have a 30 minute walk route so will give it a go. Thanks.

yarwell

is there a reference for the effect of fructose on the liver despite calorie restriction study ?

Gianfranco_R

andrikosDE wrote: »

So among all the podcasts I listen to daily during my commute, this one made me stop, think and give it a second listen.

http://www.scientificamerican.com/podcast/episode/the-hunt-for-the-fat-gene/

If you have time to listen to it, I have a feeling you'll be as blown away as I was...

It refers to this article (requires subscription)
http://www.scientificamerican.com/article/ancient-mutation-in-apes-may-explain-human-obesity-and-diabetes/

But to hear it from the professor himself describing his investigation over the decades is truly fascinating.

If you have time, please give it a listen, it's about 30 minutes long.

Thanks. Found this paper on the subject:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956161/

andrikosDE

yarwell wrote: »

is there a reference for the effect of fructose on the liver despite calorie restriction study ?

Yep. On rats. Who do have the Uricase enzyme, so I have no idea how applicable it is to humans.

Gianfranco_R

Gianfranco_R wrote: »

andrikosDE wrote: »

So among all the podcasts I listen to daily during my commute, this one made me stop, think and give it a second listen.

http://www.scientificamerican.com/podcast/episode/the-hunt-for-the-fat-gene/

If you have time to listen to it, I have a feeling you'll be as blown away as I was...

It refers to this article (requires subscription)
http://www.scientificamerican.com/article/ancient-mutation-in-apes-may-explain-human-obesity-and-diabetes/

But to hear it from the professor himself describing his investigation over the decades is truly fascinating.

If you have time, please give it a listen, it's about 30 minutes long.

Thanks. Found this paper on the subject:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956161/

and this:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203212/

Gianfranco_R

Gianfranco_R wrote: »

Gianfranco_R wrote: »

andrikosDE wrote: »

So among all the podcasts I listen to daily during my commute, this one made me stop, think and give it a second listen.

http://www.scientificamerican.com/podcast/episode/the-hunt-for-the-fat-gene/

If you have time to listen to it, I have a feeling you'll be as blown away as I was...

It refers to this article (requires subscription)
http://www.scientificamerican.com/article/ancient-mutation-in-apes-may-explain-human-obesity-and-diabetes/

But to hear it from the professor himself describing his investigation over the decades is truly fascinating.

If you have time, please give it a listen, it's about 30 minutes long.

Thanks. Found this paper on the subject:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956161/

and this:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203212/

uhm...
Conflict of Interest

Dr Johnson and Dr Lanaspa are listed as inventors on patent applications to lower uric acid or block fructose metabolism as a means for treating obesity and metabolic syndrome or related conditions.

andrikosDE

Uh huh. Fascinating.
Thanks for listing the publications. I'm open to the science. Not so open to people who want to sell their wares by potential misinformation.

stealthq

Gianfranco_R wrote: »

Gianfranco_R wrote: »

Gianfranco_R wrote: »

andrikosDE wrote: »

So among all the podcasts I listen to daily during my commute, this one made me stop, think and give it a second listen.

http://www.scientificamerican.com/podcast/episode/the-hunt-for-the-fat-gene/

If you have time to listen to it, I have a feeling you'll be as blown away as I was...

It refers to this article (requires subscription)
http://www.scientificamerican.com/article/ancient-mutation-in-apes-may-explain-human-obesity-and-diabetes/

But to hear it from the professor himself describing his investigation over the decades is truly fascinating.

If you have time, please give it a listen, it's about 30 minutes long.

Thanks. Found this paper on the subject:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956161/

and this:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203212/

uhm...
Conflict of Interest

Dr Johnson and Dr Lanaspa are listed as inventors on patent applications to lower uric acid or block fructose metabolism as a means for treating obesity and metabolic syndrome or related conditions.

andrikosDE wrote: »

Uh huh. Fascinating.
Thanks for listing the publications. I'm open to the science. Not so open to people who want to sell their wares by potential misinformation.

Question is, are the patents the chicken or the egg?

That is, did they file the patents because they'd already done the research and they think their science is good and solid, or did they come up with a hypothesis, file a patent based on that, and then design their research (and publication) to back both.

I've seen it done both ways, which is part of why I don't automatically discount research if the scientist profits from some aspect of it. The other part being that sometimes even the sketchy latter method turns out correct conclusions.

Lourdesong

I listened to it last night. It was interesting. I don't know what to think of his ideas or research, though, or even if it makes sense.
I'm mostly interested in further discussion his research may prompt.

yarwell

http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2015.OABA.6.PP07-3 - reducing fructose but not calories in kids.

Gianfranco_R

yarwell wrote: »

http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2015.OABA.6.PP07-3 - reducing fructose but not calories in kids.

why just Latino and African American?

yarwell

Gianfranco_R wrote: »

yarwell wrote: »

http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2015.OABA.6.PP07-3 - reducing fructose but not calories in kids.

why just Latino and African American?

no idea. The researchers home town is ethnically very mixed perhaps there's a perceived issue in those racial groups (massive soda consumption ?) or it reflects an interest of the researchers or backers.

Patttience

Well i haven't got time to listen to it right now but maybe later. I will say this though, having a genetic disposition to making you fat does not mean you HAVE to be fat. It means you are more likely to get fat when food is plentiful. This means that if you have the fat gene and you don't want to be fat, you will have to pay a bit more attention to maintaining a low body weight than people who don't have the fat gene.

Patttience

"Underlying" does not mean "cause".