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Coffee consumption promotes muscle hypertrophy

ecjimecjim Member Posts: 889 Member Member Posts: 889 Member
Who knew? - I think I'll make a pot

Coffee consumption promotes skeletal muscle hypertrophy and myoblast differentiation

Coffee is a widely consumed beverage worldwide and is believed to help prevent the occurrence of various chronic diseases. However, the effect of coffee on skeletal muscle hypertrophy, differentiation and the mechanisms of action responsible have remained unclear. To investigate the effect of coffee on skeletal muscle hypertrophy, mice were fed a normal diet or a normal diet supplemented with 0.3% coffee or 1% coffee. Coffee supplementation was observed to increase skeletal muscle hypertrophy, while simultaneously upregulating protein expression of total MHC, MHC2A, and MHC2B in quadricep muscle. Myostatin expression was also attenuated, and IGF1 was upregulated with subsequent phosphorylation of Akt and mTOR, while AMPK phosphorylation was attenuated. Coffee also increased the grip strength and PGC-1α protein expression, and decreased the expressions of TGF-β and myostatin in tricep muscle. Coffee activated the MKK3/6-p38 pathway and upregulated PGC-1α, which may play a role in promoting myogenic differentiation and myogenin expression in C2C12 cells. These results suggest that coffee increases skeletal muscle function and hypertrophy by regulating the TGF-β/myostatin - Akt - mTORC1.


  • Dogmom1978Dogmom1978 Member Posts: 1,300 Member Member Posts: 1,300 Member
    See, I knew there was an excellent reason to drink coffee! 😜

    Luckily, I already filter my water through coffee grounds. 😂
  • watts6151watts6151 Member, Premium Posts: 774 Member Member, Premium Posts: 774 Member
    I should definitely be winning the Olympia with the amount I drink ☕️☕️☕️
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