Restarting weightloss

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Hi, I've struggled with my weight my whole life. Last year I had finally gotten below 200lbs from 285lbs. Currently I am 228lbs. My lowest this time was 188lbs. When I got sick I gained a lot of weight back and lost a lot of muscle. We still don't know why I'm sick. We are thinking my heart. Im so frustrated with myself and not sure where to turn. My question is where do I start again? What can I do to get back into the grove of things again? Anything helpful is appreciated. Thank you in advance.