First week of Zepbound

it’s taken a lot of thought and frustration to get me to taking Zepbound. Firstly, it’s darn expensive (am self paying) and then all the noise about nausea and other GI issues.

Must say I am eating better and smaller amounts (as much protein as I can), drinking water and starting to move more. I only had one issue after eating a homemade portobello mushroom pizza! Probably the fat but definitely caused lower GZi distress.

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  • ckmb2272
    ckmb2272 Posts: 1 Member

    week 1 here too. ZERO appetite. Yikes!

  • KSDurand
    KSDurand Posts: 3 Member

    i am on zep and started in May. I’m at 2.5 dose for every 14 days now. I’m so scared of going back to old eating habits, but i want to lend my support to you! I had really positive experience with it!

  • tnwombles
    tnwombles Posts: 7 Member

    I just took my first dose on Tuesday. I had immediate nausea and felt hungover for several hours afterwards. No issues since then except for less food noise and full faster. Let’s do this!!

  • Kkadler
    Kkadler Posts: 2 Member

    I’ve been on Zepbound for one year and have lost 38 pounds. I still want to lose another 40 or so, but I might have to go off it due to cost. You have to force yourself to eat sometimes, but if you don’t you’ll never learn how to eat properly. It’s a great time to explore everything in moderation since you’re not hungry and will fill up quickly. Beware of constipation!!! Drink plenty of water.

  • EJY129
    EJY129 Posts: 1 Member

    It took a lot of convincing for me too. I was very afraid of side effects. I have gone up and down with weight the last 15 years. Most recent goal weight happy was right before pandemic doing ideal protein and running for first time ever at 52. Tried ideal protein and optivia and both got me to where I am right now without zepbound but it took 9 months instead of 2.5 months. Now I am on my 12th week of zepbound on 5th shot at 5mg. August 11 start. I’ve lost 37lbs so far. I have very little appetite for anything. I stopped drinking alcohol entirely because I was afraid of side effects. I am here because this week I am barely losing a pound and I felt like talking to others struggling. It’s changed my entire social life to not be hungry or drink. No more fabulous dinners out. No more going out for a drink on my own to just get out of the house and meet people. I love to cook. I love food. All of that true enjoyment is gone. It’s like someone turned off the enjoyment receptors in my brain. I have described it as an antidepressant for the stomach. I got some nausea and gastric distress at first. I don’t get as much now. I keep Pepto tablets near my bed. If I’m nauseous it’s usually the second or third day. I try to make sure I get protein. Chicken broth from Brodo and Greek Yogurt are now my go to meals and snacks. You’ll know when it’s time to increase dose because the cravings come back. For me it was walking by a pizza place and thinking “that smells good”. I realized I hadn’t thought those words in a month. It just shuts off the hunger or desire. It’s kind of bizarre but it works. But on a week like this week where I ate out twice and barely had anything and I’m not going to lose two pounds I think “why am I depriving myself of joy if this isn’t going to keep working?” I’m impatient :) good luck. Get some protein shakes. Chicken broth. Fage yogurt. Salami cheese roll ups.hard oiled eggs. And Pepto chewables. Even a glass of whole milk has 10g of protein. Protein protein protein.

  • 628462
    628462 Posts: 70 Member
    edited October 23

    I'm on shot#8 at 5mg. Lost 24lbs in 8weeks. No side effects yet but next shot is 7.5mg which I'm a little concerned about (several posts elsewhere about side effects starting at 7.5) The weightloss has me very motivated to walk dog, move, do exercises to maintain muscle, etc.

    Unfortunately I don't see how I can keep all this weight off forever (without glp help), but I'm trying not to stress about that right now.

  • jzvfrb2bdh
    jzvfrb2bdh Posts: 1 Member

    Took my 3rd of 2.5mg this morning. Haven’t had any GI issues. I did have very bad chills after my 1st but that went away by the next morning.

    My problem is sleep. I work the night shift and I know sleep is a big aspect of weight loss. Interested to learn how the night shifters out there are prioritizing sleep and increasing your protein intake.

  • Tattoomama4440
    Tattoomama4440 Posts: 27 Member

    It works! I have had great luck. On week 4 and down 7 pounds. It is expensive unfortunately but it’s an investment in your health. Keep us posted on how you are doing.

  • anw1955
    anw1955 Posts: 1 Member

    Had 2nd 2.5 Zepbound today. So far so good and no side effects. Definitely helps with food noise and satiety. Also paying through Lilly Direct. I waited a long time also before taking the leap because of all the talk of side effects.

  • MNCold
    MNCold Posts: 1 Member

    I am on my 1st week of Semiglutide shots. I am motivated and have started eating well and moving more. I look forward to the journey in front of me and will be here keeping up with all of your successes and bumps in the road.

  • BarbLoki
    BarbLoki Posts: 8 Member

    I started 2.5mg Zepbound on 11/8/25. I took my third shot 2 days ago. No side effects so far and still craving certain favorite foods. I'm worried I won't be able to get enough protein. Not even sure how much protein is enough per day. I think I need to meet with a nutritionist. I'm also concerned about the cost but right now my insurance is helping with it as it was prescribed for OSA which is covered but weight loss is not. Go figure.