Artificial Sweeteners and POSSIBLE Glucose Intolerance
MeMyCatsandI
Posts: 704 Member
Disclaimer
************
I am NOT advocating for OR against artificial sweeteners. And I am not saying they are good for you OR bad for you.
************
I don't drink soda very often, but when I do it's diet. I do, however, use a minimum of 4 Sweet n' Low packets on a daily basis. So I found this article from PBS interesting. Instead of the typical argument about whether or not diet drinks make you lose or gain weight, this one is specific to the possibility that they might cause glucose intolerance and eventually diabetes.
People are free to consume artificial sweeteners or not. Personally, I do and will probably continue unless/until more conclusive research shows that it's dangerous. And before anybody goes crazy on one side of the artificial sweetener debate or the other, the article CLEARLY states that more research needs to be done (on a large scale) to determine the effects of artificial sweeteners and glucose intolerance. (Quote from article: "It's much too early, on the basis of this one study, [to conclude that] artificial sweeteners have negative impacts on humans' [risk for diabetes]")
Something that I found interesting is that the artificial sweeteners seem to affect different people differently (specifically the microbes in the gut), which they say could be the reason why some studies show weight gain and others show weight loss. It could also mean that artificial sweeteners may potentially cause glucose intolerance in some people and not in others.
Anyway, I found it interesting and thought I'd share. Here is a link to the article, which I've pasted in its entirety below.
http://www.kpbs.org/news/2014/sep/17/diet-soda-may-alter-our-gut-microbes-and-the-risk/
*************
Diet Soda May Alter Our Gut Microbes And The Risk Of Diabetes
Wednesday, September 17, 2014
Allison Aubrey / NPR
Should we drink diet soda or not? The latest study doesn't really clear things up.
The debate over whether diet sodas are good, bad or just OK for us never seems to end.
Some research suggests zero-calorie drinks can help people cut calories and fend off weight gain.
But, in recent years, the idea that artificial sweeteners may trick the brain and lead to "metabolic derangements," as one researcher has theorized, has gained traction, too.
Now, a new study published in the journal Nature introduces a new idea: diet sodas may alter our gut microbes in a way that increases the risk of metabolic diseases such as type 2 diabetes — at least in some of us.
In the paper, researchers at the Weizmann Institute of Science in Israel describe what happened when they fed mice zero-calorie sweeteners including saccharin, aspartame and sucralose.
"To our surprise, [the mice] developed glucose intolerance," Weizmann researcher Eran Elinav told us by phone.
Intrigued by the findings, Elinav and his colleague Eran Segal set out to determine if this might happen in people as well.
First, they analyzed data collected from a group of about 400 people who are enrolled in an ongoing nutrition study. They found that people who were heavy consumers of artificial sweeteners had slightly elevated HbA1C levels (a long-term measure of blood sugar) — compared to people who rarely or never consumed artificial sweeteners.
Next, they recruited seven volunteers — people who were not in the habit of drinking diet drinks — and asked them to start consuming the equivalent of 10-12 of those fake sugar packets during a one-week experiment.
"What we find is that a subgroup (four of the seven people) developed significant disturbances in their blood glucose ... even after short-term exposure to artificial sweetener," Elinav says.
For example, results of a glucose tolerance test found that the some individuals blood sugar temporarily shot up to levels that are characterized as pre-diabetic within just a few days of introducing the artificial sweetener.
"This was a surprise to us," Elinav says.
And how it's happening may be even more surprising. Their experiments showed that artificial sweetener can alter the mix of bacteria in the guts of mice and people in a way that lead some to become glucose intolerant.
"I found this work exciting, because to me it's a new idea," physician Martin Blaser, who directs the Human Microbiome Program at New York University tells us by phone.
After reading the paper, he says: "I can just tell you ... as a middle aged man who's concerned about my diet and waistline — and as somebody who drinks diet soda — I didn't drink any yesterday."
While the findings are preliminary, the paper could begin to explain why studies of diet soda point in opposite directions.
"All of us have a microbiome," made up of trillions of organisms. "It's complex and everyone's microbiome is a little different."
And the ways our microbiomes respond to what we eat can vary, too.
In the study, the Israeli researchers find that as mice and people started consuming artificial sweeteners, some types of bacteria got pushed out, and other types of bacteria began to proliferate.
It could be that for some people that responded negatively to the artificial sweetener, the bacteria that got crowded out were helping keep glucose in check.
How it's happening isn't clear. And Blaser says a lot more research is needed.
"So that's the next step," Blaser tells us. "Firstly, for [researchers] to confirm this to see if it's really true." And the next challenge is to understand the mechanism. "How does the change in the microbial composition, how is it causing this?"
Lots of researchers agree, they'd like to see a large-scale study.
"It's much too early, on the basis of this one study, [to conclude that] artificial sweeteners have negative impacts on humans' [risk for diabetes] says James Hill, director of the Center for Human Nutrition at the University of Colorado.
He points to a randomized controlled trial published in 2011 that found artificial sweeteners helped to limit the rise in blood sugar in a group of slightly overweight people, compared to sugar.
Hill also points to a study of people on the National Weight Control Registry that found successful long-term dieters tend to consume artificially-sweetened foods and beverages at a higher rate compared to the general population.
So, expect the debate over diet sodas to continue. And also anticipate hearing more about the role of our microbiomes.
It's clear that our gut microbes are not just passive organisms hitching a ride on our bodies says Kirsten Tillisch, a gastroenterologist at the University of California Los Angeles. "They're affecting our health in active and powerful ways."
Tillisch' take on the new research: it's hypothesis-generating.
She says many patients come in asking about diet sodas. Some keep drinking them, even while complaining that diet drinks give them headaches or make them feel bloated.
Her solution: drink water instead.
Copyright 2014 NPR. To see more, visit http://www.npr.org/.
Allison Aubrey / NPR
********
************
I am NOT advocating for OR against artificial sweeteners. And I am not saying they are good for you OR bad for you.
************
I don't drink soda very often, but when I do it's diet. I do, however, use a minimum of 4 Sweet n' Low packets on a daily basis. So I found this article from PBS interesting. Instead of the typical argument about whether or not diet drinks make you lose or gain weight, this one is specific to the possibility that they might cause glucose intolerance and eventually diabetes.
People are free to consume artificial sweeteners or not. Personally, I do and will probably continue unless/until more conclusive research shows that it's dangerous. And before anybody goes crazy on one side of the artificial sweetener debate or the other, the article CLEARLY states that more research needs to be done (on a large scale) to determine the effects of artificial sweeteners and glucose intolerance. (Quote from article: "It's much too early, on the basis of this one study, [to conclude that] artificial sweeteners have negative impacts on humans' [risk for diabetes]")
Something that I found interesting is that the artificial sweeteners seem to affect different people differently (specifically the microbes in the gut), which they say could be the reason why some studies show weight gain and others show weight loss. It could also mean that artificial sweeteners may potentially cause glucose intolerance in some people and not in others.
Anyway, I found it interesting and thought I'd share. Here is a link to the article, which I've pasted in its entirety below.
http://www.kpbs.org/news/2014/sep/17/diet-soda-may-alter-our-gut-microbes-and-the-risk/
*************
Diet Soda May Alter Our Gut Microbes And The Risk Of Diabetes
Wednesday, September 17, 2014
Allison Aubrey / NPR
Should we drink diet soda or not? The latest study doesn't really clear things up.
The debate over whether diet sodas are good, bad or just OK for us never seems to end.
Some research suggests zero-calorie drinks can help people cut calories and fend off weight gain.
But, in recent years, the idea that artificial sweeteners may trick the brain and lead to "metabolic derangements," as one researcher has theorized, has gained traction, too.
Now, a new study published in the journal Nature introduces a new idea: diet sodas may alter our gut microbes in a way that increases the risk of metabolic diseases such as type 2 diabetes — at least in some of us.
In the paper, researchers at the Weizmann Institute of Science in Israel describe what happened when they fed mice zero-calorie sweeteners including saccharin, aspartame and sucralose.
"To our surprise, [the mice] developed glucose intolerance," Weizmann researcher Eran Elinav told us by phone.
Intrigued by the findings, Elinav and his colleague Eran Segal set out to determine if this might happen in people as well.
First, they analyzed data collected from a group of about 400 people who are enrolled in an ongoing nutrition study. They found that people who were heavy consumers of artificial sweeteners had slightly elevated HbA1C levels (a long-term measure of blood sugar) — compared to people who rarely or never consumed artificial sweeteners.
Next, they recruited seven volunteers — people who were not in the habit of drinking diet drinks — and asked them to start consuming the equivalent of 10-12 of those fake sugar packets during a one-week experiment.
"What we find is that a subgroup (four of the seven people) developed significant disturbances in their blood glucose ... even after short-term exposure to artificial sweetener," Elinav says.
For example, results of a glucose tolerance test found that the some individuals blood sugar temporarily shot up to levels that are characterized as pre-diabetic within just a few days of introducing the artificial sweetener.
"This was a surprise to us," Elinav says.
And how it's happening may be even more surprising. Their experiments showed that artificial sweetener can alter the mix of bacteria in the guts of mice and people in a way that lead some to become glucose intolerant.
"I found this work exciting, because to me it's a new idea," physician Martin Blaser, who directs the Human Microbiome Program at New York University tells us by phone.
After reading the paper, he says: "I can just tell you ... as a middle aged man who's concerned about my diet and waistline — and as somebody who drinks diet soda — I didn't drink any yesterday."
While the findings are preliminary, the paper could begin to explain why studies of diet soda point in opposite directions.
"All of us have a microbiome," made up of trillions of organisms. "It's complex and everyone's microbiome is a little different."
And the ways our microbiomes respond to what we eat can vary, too.
In the study, the Israeli researchers find that as mice and people started consuming artificial sweeteners, some types of bacteria got pushed out, and other types of bacteria began to proliferate.
It could be that for some people that responded negatively to the artificial sweetener, the bacteria that got crowded out were helping keep glucose in check.
How it's happening isn't clear. And Blaser says a lot more research is needed.
"So that's the next step," Blaser tells us. "Firstly, for [researchers] to confirm this to see if it's really true." And the next challenge is to understand the mechanism. "How does the change in the microbial composition, how is it causing this?"
Lots of researchers agree, they'd like to see a large-scale study.
"It's much too early, on the basis of this one study, [to conclude that] artificial sweeteners have negative impacts on humans' [risk for diabetes] says James Hill, director of the Center for Human Nutrition at the University of Colorado.
He points to a randomized controlled trial published in 2011 that found artificial sweeteners helped to limit the rise in blood sugar in a group of slightly overweight people, compared to sugar.
Hill also points to a study of people on the National Weight Control Registry that found successful long-term dieters tend to consume artificially-sweetened foods and beverages at a higher rate compared to the general population.
So, expect the debate over diet sodas to continue. And also anticipate hearing more about the role of our microbiomes.
It's clear that our gut microbes are not just passive organisms hitching a ride on our bodies says Kirsten Tillisch, a gastroenterologist at the University of California Los Angeles. "They're affecting our health in active and powerful ways."
Tillisch' take on the new research: it's hypothesis-generating.
She says many patients come in asking about diet sodas. Some keep drinking them, even while complaining that diet drinks give them headaches or make them feel bloated.
Her solution: drink water instead.
Copyright 2014 NPR. To see more, visit http://www.npr.org/.
Allison Aubrey / NPR
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0
Replies
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That was a long post!
If you want to ingest them, do it.
If you don't, don't.0 -
Feeling dang good about using Equal then. Screw that Sweet and Low crapola!0
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The article I read today said this study used saccharin, sucralose, and aspartame in their testing. I would love to know if Stevia and Monk fruit (Nectresse), and also some of the alcohol sugars like Xylitol and Erythritol had similar results.
Article I saw, just for reference: http://www.huffingtonpost.com/2014/09/18/artificial-sweeteners-gut-bacteria_n_5837646.html?ncid=fcbklnkushpmg000000630 -
Your half way there, good for you! Do a little more digging and you will learn a lot more facts about this poison and hopefully never touch the stuff again. But this subject will usually start a firestorm of venomous posts from the defenders of all things unnatural and detrimental to health. I'm outta here LOL0
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I applaud you for doing research into what goes into your body. Its really important to understand. I personally have decided I'd like to avoid artificial sweeteners. But your clearly making an educated choice so Well done
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