KNEES - Help me please???

LovelySpirit

:flowerforyou: Mornin MFP fam.. yesterday I was doing squats w/ one of the B-Boys that I often rock with (Beto-Zumba or Billy Blanks-Taebo ) and my left knee sounds like someone crumbling up aluminum foil when I'm doing squats!!! What is that! How can I remedy that so as not to end up on my bottom for bad knees????? :noway:

Crystalchaos72

Maybe take glucosamine? It is a joint suppliment......since I am missing a pie piece of one kneecap, I swear by it......
It doesn't help with the crinkleing though

firegirley

YES! Mine sound like rice krispies whenever I bend. I mentioned it to my dr and she didnt seem to think it was an issue. Maybe time for a new dr?

cedarhurst2006

I affectionately refer to them as my musical knees. Honestly, I've have been putting fresh ginger slices in my tea and it works as an anti-inflammatory. I have to say, it has really helped me.

quichebradford

OMG!! Mine too! I'm curios to see what people have to say about this. Thanks for posting!

ValerieMomof2

It's most likely the cartilage underneath the knee cap. When that is injured or irritated it makes that crackling sound. Make sure you are doing squats correctly and you can wear a knee sleeve or brace that helps with tracking of the knee cap. If it's painful, ice!

TuDominicano

I'd check that out, but buy MSM pills or Glucosamine, it helps with joints, especially the knee area. Though MSM is highly recommended.

TuDominicano

Yeah, when doing squats, lunges, leg extensions or any leg workout, proper form is necessary, if not you'll wind up hurting yourself. It's all about formation and accuracy.

It's most likely the cartilage underneath the knee cap. When that is injured or irritated it makes that crackling sound. Make sure you are doing squats correctly and you can wear a knee sleeve or brace that helps with tracking of the knee cap. If it's painful, ice!

jamie78

Maybe take glucosamine? It is a joint suppliment......since I am missing a pie piece of one kneecap, I swear by it......
It doesn't help with the crinkleing though

This! I have started using it too and it seems to help!

TuDominicano

Methylsulfonylmethane (MSM) is an organosulfur compound with the formula (CH3)2SO2. It is also known by several other names including DMSO2, methyl sulfone, and dimethyl sulfone.[1] This colorless solid features the sulfonyl functional group and is considered relatively inert chemically. It occurs naturally in some primitive plants and is present in small amounts in many foods and beverages and it is marketed as a dietary supplement.

Structure and chemical propertiesMSM is structurally related to dimethyl sulfoxide (DMSO), but the behavior of these two is different. DMSO is a highly polar solvent and an excellent ligand, with water-like dissolving properties whereas MSM is less polar and less reactive. MSM is also a metabolite of DMSO.

[edit] Use as a solventBecause of its polarity and thermal stability, MSM is used industrially as a high-temperature solvent for both inorganic and organic substances. It is used as a medium in organic synthesis. For example, displacement of aryl chlorides by potassium fluoride can be usefully conducted in molten MSM.[2] With a pKa of 31, it can be deprotonated with sodium amide, and the conjugate base is an effective nucleophile.

[edit] Effects on healthStanley W. Jacob reported having administered MSM to over 18,000 patients with a variety of ailments;[3] he co-authored a book promoting MSM with a variety of claims, including its supposed utility as a natural source of "biologically active sulfur,"[4] suggesting that people are deficient in such forms of sulfur in their dietary intake. There is no Dietary Reference Intake (DRI) or Daily Value established for sulphur; it is readily available in onions, garlic and cruciferous vegetables and in protein-containing foods, including nuts, seeds, milk and eggs.[5]

The claims for the need for sulfur supplementation originate with Robert Herschler, a biochemist who patented "Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it" in 1982; he claimed that MSM was useful in stress, mucous-membrane inflammation, allergies and gastrointestinal conditions.[6] Registered dietitian Kerry Lang on quackwatch disparages this claim, pointing out:[5]

Herschler's patent documents claim that 'the average diet is deficient in methylsulfonylmethane because it is readily lost during conventional food processing, such as frying, dehydrating, dilution with synthetic fillers and other poorly nutritional additives, cooking, radiation or pasteurizing, and long-term storage.' This statement is absurd, because the amount of sulfur in protein foods is not affected by processing. Since Americans tend to consume more protein than they need, 'sulfur deficiency' is very unlikely and would not occur without obvious evidence of severe malnutrition. If it could occur, the remedy would be to eat adequate protein, not to supplement with MSM.

MSM is sold as a dietary supplement and marketed with a variety of claims, often in combination with glucosamine and/or chondroitin for helping to treat or prevent osteoarthritis. According to one review, "The benefits claimed [for MSM] far exceed the number of scientific studies. It is hard to build a strong case for its use other than for treating arthritis problems."[7] The biochemical effects of supplemental methylsulfonylmethane are poorly understood. Some researchers have suggested that MSM has anti-inflammatory effects.[8] The spectrum of biological effects of dimethyl sulfoxide (DMSO) and MSM differ, but those of DMSO may be mediated, at least in part, by MSM.[9]

[edit] FDA enforcement actionIn October 2000, the United States Food and Drug Administration warned one MSM promoter, Karl Loren, to cease and desist from making therapeutic claims for MSM, as the marketing of drugs without the approval of the FDA is illegal.[10]

[edit] Evidence from clinical trialsSmall-scale studies of possible treatments with MSM have been conducted on both animals and humans. These studies of MSM have suggested some benefits, particularly for treatment of osteoarthritis.

[edit] OsteoarthritisA review by S. Brien, P. Prescott, N. Bashir, H. Lewith and G. Lewith of the two small randomized controlled trials of methylsulfonylmethane in osteoarthritis knee pain relief[11][12] "reported significant improvement in pain outcomes in the treatment group compared to comparator treatments; however, methodological issues and concerns over optimal dosage and treatment period were highlighted."[13]

The two trials included only 168 people, of whom 52 actually received the drug, so the review authors are careful to state: "No definitive conclusion can currently be drawn" and there is no "definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee."[13] While one of the two studies suggests that taking MSM for 12 weeks or less may be safe, "further research is needed to assess its safety for long-term use."[14] Side effects of MSM ingestion include stomach upset, diarrhoea and headache.[14] In the absence of studies into dosage, longer-term safety and definitive efficacy trials, MSM must be considered experimental and should not be self-administered or prescribed outside clinical trials.[14]

After several reports that MSM helped arthritis in animal models, one study by P.R. Usha et al. had suggested that 1.5 g per day MSM (alone or in combination with glucosamine sulfate) was helpful in relieving symptoms of knee osteoarthritis.[12] The Usha clinical trial, however, was outsourced to India and conducted by researchers with little prior experience in clinical trials; tests were described without associated data, while some results were unsupported by the data that was shown. K.S. Jayaraman has warned that such outsourcing of clinical trials can be "rash" and "risky," citing deficient ethics committees as well as an unethical approach to patient recruitment.[15]

Kim et al. conducted a second clinical trial of MSM for treatment of patients with osteoarthritis of the knee. Twenty-five patients took 6 g/day MSM and 25 patients took a placebo for 12 weeks. Ten patients did not complete the study, and intention to treat analysis was performed. Patients who took MSM reported reduced pain and improved physical function, but no evidence was found of a more general anti-inflammatory effect; there were no significant changes in two measures of systemic inflammation: C-reactive protein level and erythrocyte sedimentation rate.[11] Not counting an unpublished, no-control group trial by Lawrence, these two articles are the only clinical-trial support for MSM for osteoarthritis.

[edit] Interstitial cystitisIn 1978, the FDA approved dimethyl sulfoxide (DMSO) for instillation into the bladder as a treatment for interstitial cystitis. Since DMSO is metabolized to MSM by the body, it is possible that MSM is the active ingredient in DMSO treatments.[16]

[edit] Other conditionsBarrager et al. evaluated the efficacy of MSM for hay fever.[17] Fifty-five subjects consumed 2.6 g of MSM per day for 30 days. This study was not blinded; while an improvement in symptoms was observed compared to those taking a placebo, no significant changes were observed in two indicators of inflammation (C-reactive protein and immunoglobulin E levels).

Blum & Blum also conducted a double-blind, placebo-controlled clinical trial of an MSM-containing throat spray to reduce snoring.[18]

[edit] Pharmacology and toxicityThe LD50 (dose at which 50% of test subjects are killed) of MSM is greater than 17.5 grams per kilogram of body weight. In rats, no adverse events were observed after daily doses of 2 g MSM per kg of body weight. In a 90-day follow-up study rats received daily MSM doses of 1.5 g/kg, and no changes were observed in terms of symptoms, blood chemistry or gross pathology.[19]

Nuclear magnetic resonance (NMR) studies have demonstrated that oral doses of MSM are absorbed into the blood and cross the blood-brain barrier.[20][21] An NMR study has also found detectable levels of MSM normally present in the blood and cerebrospinal fluid, suggesting that it derives from dietary sources, intestinal bacterial metabolism, and the body's endogenous methanethiol metabolism.[22]

Published clinical trials of MSM did not report any serious side effects, but there are no peer-reviewed data on the effects of its long-term use in humans.