low chewing and Alzheimer's article

wilted6orchid

Low Chewing Efforts Worsen Alzheimer’s Disease Pathology
Source: Neuroscience Letters 439 (2008): 208-211
Article Type: Original Research
Authors: Kushida S et al.

In their latest paper, Kushida and colleagues examined in Amyloid beta-infused rats the effect of soft-diet feeding on two parameters which are typically affected in Alzheimer’s Disease (AD) patients

a) the release of the neurotransmitter dopamine
b) the learning ability and memory performance

Rats were fed either a hard (standard) or soft diet for 3 weeks days. During the last 2 weeks, rat brains were continuously infused with Abeta, the putative main culprit in AD.

“We found no significant differences in the basal level of dopamine release in the hippocampus between soft- and hard-diet-fed groups; however, the dopamine release evoked by high-K Ringer’s solution was significantly different between the soft- and hard-diet-fed groups. The increase of dopamine release in the hard-diet-fed group reached 420%; however, that in the soft-diet-fed group reached only 260%. In AD model rats, dopamine release in the soft-diet-fed group was significantly less than that of the hard-diet-fed group.”

After assessing the rats in the co-called step-through passive avoidance test, the authors conclude that:

“Our results also suggest that soft-diet feeding impairs learning ability and memory in AD rats; however, the underlying mechanism is unknown. One possible explanation is that the present results may be caused by the changes of activity in sensori-motor pathways of soft-diet-fed rats.”

How does this now relate to AD patients?

“Elderly people lose many teeth as they age. The loss of teeth not only forces them to eat soft foods, but also correlates to the development of senile dementia and Alzheimer’s disease (AD).”

So might one speculate that a rather early move in life towards the consumption of soft food triggers the onset of AD? An interesting idea – although much research is needed to establish this link of cause and consequence.

Just something I found interesting. Eat something crunchy today, chew your food properly, and brush and floss...or become a gum junkie:laugh:

wilted6orchid

Low Chewing Efforts Worsen Alzheimer’s Disease Pathology
Source: Neuroscience Letters 439 (2008): 208-211
Article Type: Original Research
Authors: Kushida S et al.

In their latest paper, Kushida and colleagues examined in Amyloid beta-infused rats the effect of soft-diet feeding on two parameters which are typically affected in Alzheimer’s Disease (AD) patients

a) the release of the neurotransmitter dopamine
b) the learning ability and memory performance

Rats were fed either a hard (standard) or soft diet for 3 weeks days. During the last 2 weeks, rat brains were continuously infused with Abeta, the putative main culprit in AD.

“We found no significant differences in the basal level of dopamine release in the hippocampus between soft- and hard-diet-fed groups; however, the dopamine release evoked by high-K Ringer’s solution was significantly different between the soft- and hard-diet-fed groups. The increase of dopamine release in the hard-diet-fed group reached 420%; however, that in the soft-diet-fed group reached only 260%. In AD model rats, dopamine release in the soft-diet-fed group was significantly less than that of the hard-diet-fed group.”

After assessing the rats in the co-called step-through passive avoidance test, the authors conclude that:

“Our results also suggest that soft-diet feeding impairs learning ability and memory in AD rats; however, the underlying mechanism is unknown. One possible explanation is that the present results may be caused by the changes of activity in sensori-motor pathways of soft-diet-fed rats.”

How does this now relate to AD patients?

“Elderly people lose many teeth as they age. The loss of teeth not only forces them to eat soft foods, but also correlates to the development of senile dementia and Alzheimer’s disease (AD).”

So might one speculate that a rather early move in life towards the consumption of soft food triggers the onset of AD? An interesting idea – although much research is needed to establish this link of cause and consequence.

Just something I found interesting. Eat something crunchy today, chew your food properly, and brush and floss...or become a gum junkie:laugh: