High Fructose is Evil
AnninStPaul
Posts: 1,372 Member
High Fructose Diet Not So Sweet for the Brain
May 24, 2012 – Diets high in fructose impair cognitive function, but this is reversed when the diet is supplemented with appropriate intake of omega-3 fatty acids, new research suggests
Although the study was done in an animal model, the findings have relevance for humans, coauthor Fernando Gomez-Pinilla, PhD, from the UCLA Brain Injury Research Centre, Los Angeles, California, told Medscape Medical News.
"High fructose consumption can induce some signs of metabolic syndrome in the brain and can disrupt the signalling of the insulin receptors and reduce the action of insulin in the brain," Dr. Gomez-Pinilla said.
"On the other hand, consumption of omega-3 fatty acids, particularly decosahexanoic acid [DHA], seems to protect against the effect of this high fructose consumption. That was the most interesting thing for us, to find that these changes in the brain that the fructose was triggering, the poor learning and the other molecular changes, could be buffered by omega-3 fatty acids," he added.
The study is published in the May 1 issue of the Journal of Physiology.
Dr. Gomez-Pinilla and coauthor Rahul Agrawal, PhD, fed adult male Sprague-Dawley rats standard rat chow for 1 week and then trained them on the Barnes maze test for 5 days to learn the test.
The rats were then randomly assigned to receive an omega-3 fatty acid diet or an omega-3 fatty acid–deficient diet with or without fructose solution as drinking water for 6 weeks.
They found that the rats assigned to the omega-3 fatty acid–deficient diet showed a significant memory deficit in the Barnes maze, which was further exacerbated by fructose intake.
They also found that the omega-3 fatty acid–deficient diet, plus high fructose consumption, disrupted insulin receptor signalling in the hippocampus, a sign of insulin resistance.
Rats that received the diet rich in omega-3 fatty acids navigated the maze much faster than those that did not receive omega-3 fatty acids.
"The omega-3 fatty acid–deficient rats were slower, and their brains showed a decline in synaptic activity. Their brain cells had trouble signalling each other, disrupting the rats' ability to think clearly and recall the route they had learned 6 weeks earlier," Dr. Gomez-Pinilla said.
Treatment Implications?
Encouraged by the results from this study, Dr. Gomez-Pinilla said he is now planning to study how diet — namely, a diet deficient in omega-3 fatty acids — can affect certain brain disorders, including posttraumatic stress disorder (PTSD).
"We have the idea that the type of diet we have described in the current study, one high in sugar and low in omega-3 fatty acids, may be a factor in PTSD," he said.
For example, such a diet is typical for military personnel, who also suffer a high rate of PTSD.
"They typically consume a high caloric diet but one that is not high in the right nutrients. They are not consuming enough omega-3 fatty acids. DHA is essential for synaptic function, and this is the mechanism that makes learning and memory possible.
"Our bodies don't produce DHA, so it must be supplemented through our diet. Consuming omega-3 fatty acids regularly can protect the brain against fructose's harmful effects,"
"Amazing" Finding
Bonnie Kaplan, PhD, from the University of Alberta, Calgary, Canada, said this study confirms that food containing high amounts of sugar adversely affects brain function.
"High sugar affects synapses, and this study confirmed that. But then, the researchers showed a very interesting thing, that adequate omega-3 fatty acids provided a protective effect. The fact that eating an adequate amount of DHA protects our brain cells from what we already know to be the bad effect of an unhealthy dietary variable — that's amazing!"
Dr. Kaplan pointed out that children in North America commonly consume drinks high in fruit sugar and that many parents believe that fruit juice is somehow healthier than soda.
"Probably they are not, and the children should go back to drinking water," she said.
"This is a very important study, and I was very excited to see it. They are a very good team at UCLA, and Dr. Gomez-Pinilla in particular has contributed a lot to this literature."
The study was supported by the National Institutes of Health. Dr. Gomez-Pinilla and Dr. Kaplan have disclosed no relevant financial relationships.
J Physiol. 2012;590:2485-2499.
http://www.medscape.com/viewarticle/764469?sssdmh=dm1.787602&src=nldne
May 24, 2012 – Diets high in fructose impair cognitive function, but this is reversed when the diet is supplemented with appropriate intake of omega-3 fatty acids, new research suggests
Although the study was done in an animal model, the findings have relevance for humans, coauthor Fernando Gomez-Pinilla, PhD, from the UCLA Brain Injury Research Centre, Los Angeles, California, told Medscape Medical News.
"High fructose consumption can induce some signs of metabolic syndrome in the brain and can disrupt the signalling of the insulin receptors and reduce the action of insulin in the brain," Dr. Gomez-Pinilla said.
"On the other hand, consumption of omega-3 fatty acids, particularly decosahexanoic acid [DHA], seems to protect against the effect of this high fructose consumption. That was the most interesting thing for us, to find that these changes in the brain that the fructose was triggering, the poor learning and the other molecular changes, could be buffered by omega-3 fatty acids," he added.
The study is published in the May 1 issue of the Journal of Physiology.
Dr. Gomez-Pinilla and coauthor Rahul Agrawal, PhD, fed adult male Sprague-Dawley rats standard rat chow for 1 week and then trained them on the Barnes maze test for 5 days to learn the test.
The rats were then randomly assigned to receive an omega-3 fatty acid diet or an omega-3 fatty acid–deficient diet with or without fructose solution as drinking water for 6 weeks.
They found that the rats assigned to the omega-3 fatty acid–deficient diet showed a significant memory deficit in the Barnes maze, which was further exacerbated by fructose intake.
They also found that the omega-3 fatty acid–deficient diet, plus high fructose consumption, disrupted insulin receptor signalling in the hippocampus, a sign of insulin resistance.
Rats that received the diet rich in omega-3 fatty acids navigated the maze much faster than those that did not receive omega-3 fatty acids.
"The omega-3 fatty acid–deficient rats were slower, and their brains showed a decline in synaptic activity. Their brain cells had trouble signalling each other, disrupting the rats' ability to think clearly and recall the route they had learned 6 weeks earlier," Dr. Gomez-Pinilla said.
Treatment Implications?
Encouraged by the results from this study, Dr. Gomez-Pinilla said he is now planning to study how diet — namely, a diet deficient in omega-3 fatty acids — can affect certain brain disorders, including posttraumatic stress disorder (PTSD).
"We have the idea that the type of diet we have described in the current study, one high in sugar and low in omega-3 fatty acids, may be a factor in PTSD," he said.
For example, such a diet is typical for military personnel, who also suffer a high rate of PTSD.
"They typically consume a high caloric diet but one that is not high in the right nutrients. They are not consuming enough omega-3 fatty acids. DHA is essential for synaptic function, and this is the mechanism that makes learning and memory possible.
"Our bodies don't produce DHA, so it must be supplemented through our diet. Consuming omega-3 fatty acids regularly can protect the brain against fructose's harmful effects,"
"Amazing" Finding
Bonnie Kaplan, PhD, from the University of Alberta, Calgary, Canada, said this study confirms that food containing high amounts of sugar adversely affects brain function.
"High sugar affects synapses, and this study confirmed that. But then, the researchers showed a very interesting thing, that adequate omega-3 fatty acids provided a protective effect. The fact that eating an adequate amount of DHA protects our brain cells from what we already know to be the bad effect of an unhealthy dietary variable — that's amazing!"
Dr. Kaplan pointed out that children in North America commonly consume drinks high in fruit sugar and that many parents believe that fruit juice is somehow healthier than soda.
"Probably they are not, and the children should go back to drinking water," she said.
"This is a very important study, and I was very excited to see it. They are a very good team at UCLA, and Dr. Gomez-Pinilla in particular has contributed a lot to this literature."
The study was supported by the National Institutes of Health. Dr. Gomez-Pinilla and Dr. Kaplan have disclosed no relevant financial relationships.
J Physiol. 2012;590:2485-2499.
http://www.medscape.com/viewarticle/764469?sssdmh=dm1.787602&src=nldne
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Replies
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Bottom line: don't let your pet rat eat a lot of fructose.0
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But it tastes soooooooooooooooooo good!!! lol
All things in moderation, and all that stuff. I will never EVER give up HFCS. It's in so many yummy things
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Diets high in fructose impair cognitive function
Fruit makes you dumb ?0 -
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Although the study was done in an animal model, the findings have relevance for humans, coauthor Fernando Gomez-Pinilla, PhD
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When I read this topic, I thought of that one commercial, where they say, "Sugar is sugar"... Anyways, just stick with fruit, that is good old natural sugar. Mmmmmmmmm.0
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When I read this topic, I thought of that one commercial, where they say, "Sugar is sugar"... Anyways, just stick with fruit, that is good old natural sugar. Mmmmmmmmm.
sugar is sugar.0 -
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Although the study was done in an animal model, the findings have relevance for humans, coauthor Fernando Gomez-Pinilla, PhD
Don't worry he only means HFCS and I suppose sucroseThe important thing to remember is that not all fructose is created equal. “We’re not talking about naturally occurring fructose in fruits, which also contain important antioxidants,” explained Gomez-Pinilla. “We’re more concerned about the fructose in high-fructose corn syrup, which is added to manufactured food products as a sweetener and preservative.”0 -
Sugar..,doot doot doot doot...doot doot.....AW honey honey..
http://www.youtube.com/watch?v=0MiQzAo6Cp8 0 -
Has anyone here ever done BOTOX?0
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Sugar is NOT sugar, as some people say. High fructose corn syrup has been molecularly altered. Our bodies do not know what to do with it. It becomes a toxin. Fructose and corn syrup are not the same as high fructose corn syrup.0
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Sugar is NOT sugar, as some people say. High fructose corn syrup has been molecularly altered. Our bodies do not know what to do with it. It becomes a toxin. Fructose and corn syrup are not the same as high fructose corn syrup.
blahblah. sugar is sugar. our bodies do not know the difference0 -
:indifferent: Looking forward to all the back and forth bashing.0
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Although the study was done in an animal model, the findings have relevance for humans, coauthor Fernando Gomez-Pinilla, PhD
lol0 -
the fructose in fruit is quite a bit less then the High fructose that is added to things. Fruit does not make you dumb and it is ignorant to take that from this statement. High fructose corn syrup is derived from corn....it does not occur naturally. I am not sure how they can call it natural and sugar is sugar as t he commercial says but since you can get it in nature that seems a little fishy to me. As with anything moderation is the key and if you choose to consume HFCS then just beware and use it in moderation.Diets high in fructose impair cognitive function
Fruit makes you dumb ?0 -
Sugar is NOT sugar, as some people say. High fructose corn syrup has been molecularly altered. Our bodies do not know what to do with it. It becomes a toxin. Fructose and corn syrup are not the same as high fructose corn syrup.
What does our body do with HFCS and how does this differ from what our body does with fructose from other sources?
How is HFCS toxic and more specifically, at what dosage?0 -
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Eating an apple and getting dumber as I type ...0
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Sugar is NOT sugar, as some people say. High fructose corn syrup has been molecularly altered. Our bodies do not know what to do with it. It becomes a toxin. Fructose and corn syrup are not the same as high fructose corn syrup.
Fructose is not "a toxin", and neither is sugar in general for that matter. Your body is not confused. Fructose is not "bad". Excess fructose CAN be "bad" in certain conditions. But an excess of anything is usually "bad".
Along with the other links provided in this thread, read this:
http://www.bodyrecomposition.com/research-review/straight-talk-about-high-fructose-corn-syrup-what-it-is-and-what-it-aint-research-review.html0 -
Although the study was done in an animal model, the findings have relevance for humans, coauthor Fernando Gomez-Pinilla, PhD
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I see a ugly A** car with ugly A** guy lol
You wish :smokin:0 -
Well, being a consumer, I vote with my dollars. I purchase products with sugar over HFCS. All I say, is give me, the consumer the choice.
If HFCS is good for "you", fine, great, buy and consume in it healthy quantities, if I'd rather ingest "raw sugar", why does it bug you?
I don't need an article telling me what is good and bad. I know what "I" like, I know what tastes good to "me". If you like HFCS, great, I teach my kids to avoid it. I teach them to purchase organic foods. Why? I like it, it tastes good. Great.
You want to teach your kids to purchase HFCS and if the box says "Healthy Choice" is better than the other box, great. That's your choice.
We both choose to vote differently with our dollars. I just ask ALL the companies to offer both, sugar and HFCS to me, the consumer.
To each his own. Peace.0 -
Actually artificial sweeteners are EVIL. Did you know Truvia is made using 40 chemical compounds and the FDA does not require they list it?
Monsanto is EVIL.
GMOs are often evil (the US does not even label them and most countries in the world ban the use of them)
Oh, and the fact that TWO out of every THREE children born after the year 2000 will get diabetes. Now that's evil.
HFCS, not evil. It's the packaged food that contains them that's evil.0 -
bump to read later0
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I hear it's cool to make blanket statements that ignore dosage and context.0
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If the stuff is toxic then why do food companies use it in the foods that the make and we buy? HMMMMM......best to cook at home as much as you can, our food in this day and time have been poluted in some way or another......UUUGG!!!!0
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I hear it's cool to make blanket statements that ignore dosage and context.
If making blanket statements that ignore dosage and context.are cool consider Lustig, Miles Davis.0 -
I hear it's cool to make blanket statements that ignore dosage and context.
If making blanket statements that ignore dosage and context.are call consider Lustig, Miles Davis.
I approve of your Billy Madison-joke-turned-on-Lustig.0
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