Reversing Type 2 Diabetes - new research Newcastle Uni

For those trying to lose weight to improve diabetes or reduce the risk of getting it, this might prove a very interesting link. Essentially it's about following a minimum calorie diet for a couple of weeks to spark the pancreas back into action. The trials have been very successful. Here's the link: http://www.ncl.ac.uk/magres/research/diabetes/reversal.htm :happy:
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Replies

  • AlabasterVerve
    AlabasterVerve Posts: 3,171 Member
    Fantastic, thanks for posting.
  • Rambopal
    Rambopal Posts: 4 Member
    Thank you for posting this. Interesting.
  • AlabasterVerve
    AlabasterVerve Posts: 3,171 Member
    Can this be taken seriously? The study was from two years ago but I haven't heard anything about it -- did I just miss it? I would have thought there would have been more coverage of this but so far the only thing I've found was this article:

    http://www.healthcanal.com/metabolic-problems/diabetes/41385-tv-special-shows-diet-reverses-type-2-diabetes.html

    That and this line from the site you linked to has me wondering...
    Do bear in mind that your doctor will be wary of information from the internet – but this comes from Newcastle University.
    Why isn't this a thing? Is it because there's something wrong with the research?
  • Akimajuktuq
    Akimajuktuq Posts: 3,037 Member
    Can this be taken seriously? The study was from two years ago but I haven't heard anything about it -- did I just miss it? I would have thought there would have been more coverage of this but so far the only thing I've found was this article:

    http://www.healthcanal.com/metabolic-problems/diabetes/41385-tv-special-shows-diet-reverses-type-2-diabetes.html

    That and this line from the site you linked to has me wondering...
    Do bear in mind that your doctor will be wary of information from the internet – but this comes from Newcastle University.
    Why isn't this a thing? Is it because there's something wrong with the research?

    So, if it isn't announced via the media then it isn't "real"? You do know that what we are presented on tv is only the part of the story right? You know how tv gets to us-it's funded by certain interest groups. Research that has shown processed foods to be detrimental to health rarely get airtime but "research" that suggests things like "eating eggs as bad as smoking cigarettes" does (and the study actually shows no such thing). Do ya think there might be a reason for that? Seen any commercials lately? What kinds of food are being advertised? Ok, now stick with me... those companies are the ones paying for your program.
  • bmreed0920
    bmreed0920 Posts: 139 Member
    Looks interesting. Thank you for sharing.
  • SirBonerFart
    SirBonerFart Posts: 1,185 Member
    I don't think it's any secret losing weight can prevent type 2 diabetes
  • AlabasterVerve
    AlabasterVerve Posts: 3,171 Member
    So, if it isn't announced via the media then it isn't "real"? blah blah blah
    '
    I don't watch TV -- I don't even buy cable just some sort of antenna service so no, I haven't seen any commercials lately. I also haven't seen anything about this research anywhere mainstream or alternative outlets. So if you stick with me... is this credible?
  • AlabasterVerve
    AlabasterVerve Posts: 3,171 Member
    I don't think it's any secret losing weight can prevent type 2 diabetes
    You didn't read the information that was linked to did you?
  • Pearsquared
    Pearsquared Posts: 1,656 Member
    "Only when a person has more fat than they can cope with does type 2 diabetes develop. In other words, once a person crosses their personal fat threshold, type 2 diabetes develops. Once they successfully lose weight and go below their personal fat threshold, diabetes will disappear."

    Interesting claim. I wonder how much research they've done into helping doctors determine what their patients' thresholds are. Certainly, keeping a healthy weight is going to be the goal, but some people may be in more danger of crossing over than others, and need more aggressive intervention.

    That totes sounds like a drug intervention, lol.
  • Binkie1955
    Binkie1955 Posts: 329 Member
    thanks so much keep sharing what you find. we're obviously not well informed by American media.
  • MutterGans
    MutterGans Posts: 47 Member
    Glad some of you good folks out there found this interesting....I'm a bit of a science geek. University research departments have trouble getting their research out there and to us, so I always try to go to the source. If any of you LOVE science research to (all science, not just diet related) then I can recommend http://www.sciencedaily.com/news which will provide you with a plethora of great links to the latest research.

    There's some really exciting research currently being done on gut bacteria - not just bifida etc, but the thousands of other types that keep us alive by living in our digestive system. The most groundbreaking treatment for IBS etc at the moment is faecal transplants. Yup, they stick someone elses poo in you! Also they've discovered that our gut bacteria isn't just related to the food we eat and the country we live in, but is consistant with where our ancient ancesters were from.
    Interesting that as we wipe out thousands of strains of friendly gut bacteria, our rates of cancer are going through the roof isn't it? So think twice about taking those antibiotics!
  • nataliea683
    nataliea683 Posts: 64 Member
    Can this be taken seriously? The study was from two years ago but I haven't heard anything about it -- did I just miss it? I would have thought there would have been more coverage of this but so far the only thing I've found was this article:

    http://www.healthcanal.com/metabolic-problems/diabetes/41385-tv-special-shows-diet-reverses-type-2-diabetes.html

    That and this line from the site you linked to has me wondering...


    QUOTE:
    Do bear in mind that your doctor will be wary of information from the internet – but this comes from Newcastle University.

    Why isn't this a thing? Is it because there's something wrong with the research?

    i actually used to work for the Professor who done this research and regularly saw the patients who took part in the trial. it really does work if it is followed correctly and under dr supervision. it did get quite alot of media coverage. we also did the diet show with the hairy bikers its the professor on there who developed the trial.
  • nataliea683
    nataliea683 Posts: 64 Member
    Can this be taken seriously? The study was from two years ago but I haven't heard anything about it -- did I just miss it? I would have thought there would have been more coverage of this but so far the only thing I've found was this article:

    http://www.healthcanal.com/metabolic-problems/diabetes/41385-tv-special-shows-diet-reverses-type-2-diabetes.html

    That and this line from the site you linked to has me wondering...


    QUOTE:
    Do bear in mind that your doctor will be wary of information from the internet – but this comes from Newcastle University.

    Why isn't this a thing? Is it because there's something wrong with the research?

    i actually used to work for the Professor who done this research and regularly saw the patients who took part in the trial. it really does work if it is followed correctly and under dr supervision. it did get quite alot of media coverage. we also did the diet show with the hairy bikers its the professor on there who developed the trial.
  • AbsoluteNG
    AbsoluteNG Posts: 1,079 Member
    Thanks, been meaning to find the group behind the research paper. The problem with this approach is that many people feel it is unethical to tell someone to eat only 500 calories but when you are facing a life threatening illness, this is really your only best option. Nobody dies due to diabetes, they die to diabetic complications. Two of the biggest diabetic complications include Atherosclerosis(Heart Attack) and cancer.

    There is a member of the intermittent fasting forums who was able to put his Type 2 diabetic condition into remission by using the Intermittent fasting approach. He did alternate day fasting. Instead of eating 500 calories everyday for the rest of his life, he alternated between high and low days.


    .
  • djshari
    djshari Posts: 513 Member
    I think this falls under extreme - for one not everyone is overweight but for those who are and can of course there are benefits. I think if someone were considering weight loss surgery this would be the same thing without surgery - in that case it may be safer... obviously with a doctor overseeing.
  • AbsoluteNG
    AbsoluteNG Posts: 1,079 Member
    I think this falls under extreme - for one not everyone is overweight but for those who are and can of course there are benefits. I think if someone were considering weight loss surgery this would be the same thing without surgery - in that case it may be safer... obviously with a doctor overseeing.

    The American Medical Association has recommended that a BMI of 30 or, 30 pounds of extra fat is when you should be tested for Diabetes. One third of the American population already hits that number, and one third of the American population is estimated to be insulin resistant. Becoming insulin resistant happens right before you become a Type 2 diabetic and the research shows that insulin resistant can be reversed as the paper specifically mentioned that phase 1 insulin response coming back to life. Oral Glucose Tolerance Test is how one can test for insulin resistance, the study in the paper even uses it to determine if phase 1 insulin response came back to life.
  • stefjc
    stefjc Posts: 484 Member
    It was all over the telly here for a few weeks, the Michael Mosely programme, books etc also refer to it, and other similar research.

    It is out there. As more IF studies are being started they all seem to look at many variations of short bursts of calorie restriction. Journals related to endocrinology have some interesting first findings, mainly animal still but more short term human studies too.

    I will be interested to see the results of a possible pan European longitudinal study - whilst that would take decades to complete the interim findings will be interesting.

    Anyone with type 2 should be able to ask their GP or diabetic nurse and get some helpful info now.
  • MzPix
    MzPix Posts: 177 Member
    Bump.
    (Need to read the article but don't have time right now.)
  • richardheath
    richardheath Posts: 1,276 Member
    Interesting. Here is a link to the PDF of the original article for those interested: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/pdf/125_2011_Article_2204.pdf

    The idea for the study was sparked, apparently, by noticing that patients having bariatric surgery had improved blood sugar levels 1 week after surgery - too soon for any weight loss related improvements were expected. So, they studied the idea that sudden calorie restriction might be at play here.

    The diet itself was 8 weeks of liquid Optifast with 3 portions per day of non-starchy vegetables. Total calorie intake was about 600 per day. 4 people could not stay on the diet, leaving the 11 diabetics.

    The trial was very small, but they do appear to show that insulin production in response to glucose and protein was at least partially restored in these individuals. Of the 11, 7 passed a glucose tolerance test while 3 did not (one did not get retested) 12 weeks after completion of the 8 week low cal diet. H1Ac levels remained low in all.

    Average weight loss in the 8 week diet was 15 kg; average weight regained in the following 12 weeks was 3 kg.

    The authors suggest that pancreatic fat might act as a marker for toxic fat break down products. And it is the levels of these, not the fat per se, that might trigger T2D in different individuals.

    Hepatic fat content fell rapidly in the first week of the diet and a decrease in glucose secretion from the liver was also observed.


    So: in summary. It does seem a promising approach, although compliance to a 600 cal/day diet might be low. Also, the sample size was very small and the follow up not very long, so further work is definitely needed before you could say that this approach should be recommended for everyone.
  • MutterGans
    MutterGans Posts: 47 Member
    It's really interesting isn't it. Certainly I'll be doing more reading on it. Thanks for link.
  • jetlag
    jetlag Posts: 800 Member
    This study was actually the basis of a big brother style weight loss experiment shown on British telly just last week.

    They picked 6 obese and diabetic women and divided them into 2 groups. The "danger" group were put on a strict 600 calorie a day liquid diet (think slim fast) and the other 3 were put on a 1600 calorie a day food diet, can't remember the exact macro ratio, but it was a perfectly long-term liveable diet.

    From what I remember, the food eaters lost weight, stuck to their diets and 2 of them were no longer diabetic.
    The liquid dieters lost weight (and one participant, who dropped out) but both of the remaining people were still diabetic, though they had improved.

    This tells me that it is perfectly possible to reverse Type 2 diabetes, it would seem and you do not have to starve yourself to do it.
  • MyaPapaya75
    MyaPapaya75 Posts: 3,143 Member
    nice article...I cut my cals and carbs it took about 6months of dedication no excuses and exercise, no meds and I'm Diabetes free..I still test always to be sure but my A1c remains 5.6 and under
  • hanwyz
    hanwyz Posts: 37 Member
    Haven't read the article yet, but just wanted to say that my ex's grandma was diabetic, she lost weight on weight watchers and her diabetes basically went away - she was off all the medication for it and her doctor actually asked if she was sure she was diabetic with the readings of insulin and blood glucose that he had taken...
  • Cayjominara
    Cayjominara Posts: 270 Member
    I came across this same article back in September of this year. I am diabetic and have been for 10 years. I am 43 years old and have suffered some of the side effects of this disease. After watching 6 family members and 3 friends die from diabetic complications, I decided I needed to take this WAY more seriously. In August, I stopped playing around with my health and started working out at leadt 4 days a week for 60 minutes. I began to change my diet and got rid of the sugar, the flour, the bread, the pasta, the fried stuff,the potatoes, the processed and fast foods, but my glucose readings were still out of range. My fasting sugars are usually 200 or so. Even with the diet and exercise, I did not see any weight loss. I increased the water to 96 oz. per day and stopped drinking pop. Then I read about the Newcastle diet. I researched it and researched it. I read about others that had tried it. The diet is extremely restricting and very challenging. But I figured I needed something drastic if I was going to get over this diabetes. On November 4th I started it. At that time I weighed 229 lbs. I'm 6'5" and people always ask me why I'm trying to lose weight because I don't "look fat". I carry most of it in my mid-section. Before I started working out I was 236 lbs. and jiggly everywhere, meaning I have a high percentage of body fat. Anyway, I have been sticking to the Newcastle diet pretty stringently. I have had a couple of hiccups, but we all make mistakes, right? It's a process. Today, I am down to 223 lbs. I am feeling and looking better than I have in years. My fasting blood sugars have been no higher than 132. Most of the time I get reading between 99 and 121. They haven't been that low since before 2003!!! I continue to exercise, so when I get down to my target weight, I'll have some muscle to work with. I am a believer in this Newcastle thing. I modified it a bit to allow for 1000 calories. I have only reached that margin twice since the beginning of the month. I often consume no more than 700 calories. It's tough and it requires great mental fortitude. My wife and children are in full support. Thanksgiving is this week, so I've been a bit nervous about caving in to the inevitable temptation of all that good food! My wife said she'll make me a really nice looking salad! LOL!

    I think this diet is worth a second look. I can't believe how my body and system has already transormed so much in this small amount of time. the 8 weeks will end on December 30th. I can hardly wait to see how I've progressed!
  • Rocbola
    Rocbola Posts: 1,998 Member
    You do know that what we are presented on tv is only the part of the story right? You know how tv gets to us-it's funded by certain interest groups. Research that has shown processed foods to be detrimental to health rarely get airtime but "research" that suggests things like "eating eggs as bad as smoking cigarettes" does (and the study actually shows no such thing). Do ya think there might be a reason for that? Seen any commercials lately? What kinds of food are being advertised? Ok, now stick with me... those companies are the ones paying for your program.
    This!!!

    Any one interested in reversing their type 2 diabetes through dietary changes should google Dr. Neal Barnard, and his organization The Physicians Committee For Responsible Medicine. (PCRM.org)
  • acpgee
    acpgee Posts: 7,902 Member
    Today's the day I reversed my diabetes diagnosis. Started dieting and exercising August 2012 when I got diagnosed with T2. After dropping some weight six months in, was given the green light to experiment with reducing my metformin. Have kept my hba1c at 4.9 the last six months, and kept reducing metformin down from original prescription of 2000 mg daily to 500 mg every other day. Today I was instructed to stop medicating altogether.
  • Cayjominara
    Cayjominara Posts: 270 Member
    Today's the day I reversed my diabetes diagnosis. Started dieting and exercising August 2012 when I got diagnosed with T2. After dropping some weight six months in, was given the green light to experiment with reducing my metformin. Have kept my hba1c at 4.9 the last six months, and kept reducing metformin down from original prescription of 2000 mg daily to 500 mg every other day. Today I was instructed to stop medicating altogether.

    That is AMAZING news! I am so happy for you! I can only dream of the day I get that SAME instruction from my doctor! Way to motivate us!
  • wildchildzoom
    wildchildzoom Posts: 5 Member
    This is very interesting....Even though I cannot do 500-1000 calories a day I do workout and do weight training. My A1c last year January was 6.8, recently i was tested at 5.8 and continue to try to lower it. Hopefully the weight training will bring that extra boost to bring it down even more. That is my dream to not have to take Metformin anymore!
  • acpgee
    acpgee Posts: 7,902 Member
    This is very interesting....Even though I cannot do 500-1000 calories a day I do workout and do weight training. My A1c last year January was 6.8, recently i was tested at 5.8 and continue to try to lower it. Hopefully the weight training will bring that extra boost to bring it down even more. That is my dream to not have to take Metformin anymore!

    I didn't follow the Newcastle very low calorie plan, but still managed to get to the point where i was instructed to stop meds after months of being on a more normal deficit. I had to lose almost 20% of bodyweight to get there.

    I think Newcastle study says that the BMI threshold at which people stop being diabetic varies wildly, depending on their predisposition to store fat in the liver and pancreas. For one person it might be BMI=40, for another unlucky person it could be BMI=22.
  • I'm very interested in this discussion.