Coffee consumption promotes muscle hypertrophy

Who knew? - I think I'll make a pot

https://pubmed.ncbi.nlm.nih.gov/29359224/

Coffee consumption promotes skeletal muscle hypertrophy and myoblast differentiation

Abstract
Coffee is a widely consumed beverage worldwide and is believed to help prevent the occurrence of various chronic diseases. However, the effect of coffee on skeletal muscle hypertrophy, differentiation and the mechanisms of action responsible have remained unclear. To investigate the effect of coffee on skeletal muscle hypertrophy, mice were fed a normal diet or a normal diet supplemented with 0.3% coffee or 1% coffee. Coffee supplementation was observed to increase skeletal muscle hypertrophy, while simultaneously upregulating protein expression of total MHC, MHC2A, and MHC2B in quadricep muscle. Myostatin expression was also attenuated, and IGF1 was upregulated with subsequent phosphorylation of Akt and mTOR, while AMPK phosphorylation was attenuated. Coffee also increased the grip strength and PGC-1α protein expression, and decreased the expressions of TGF-β and myostatin in tricep muscle. Coffee activated the MKK3/6-p38 pathway and upregulated PGC-1α, which may play a role in promoting myogenic differentiation and myogenin expression in C2C12 cells. These results suggest that coffee increases skeletal muscle function and hypertrophy by regulating the TGF-β/myostatin - Akt - mTORC1.

Replies

  • Dogmom1978
    Dogmom1978 Posts: 1,581 Member
    See, I knew there was an excellent reason to drink coffee! 😜

    Luckily, I already filter my water through coffee grounds. 😂
  • watts6151
    watts6151 Posts: 898 Member
    I should definitely be winning the Olympia with the amount I drink ☕️☕️☕️
  • alexmose
    alexmose Posts: 793 Member
    I know that I lift more weight with coffee in me!!
  • ecjim
    ecjim Posts: 960 Member
    alexmose wrote: »
    I know that I lift more weight with coffee in me!!

    There ya go - We have proof
  • youngmomtaz
    youngmomtaz Posts: 1,075 Member
    alexmose wrote: »
    I know that I lift more weight with coffee in me!!

    Me too! I had to be off coffee before minor surgery once. I was sad and the low energy made me feel like lifting would suck. A good punch of caffeine before weights keeps me going.