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Sugar, The Bitter Truth
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Why use crash test dummies in car tests? They aren't anywhere near human.ParadigmShifter wrote: »ParadigmShifter wrote: »
Then why even do studies on animals?
Because they can't do any human studies until they prove that whatever it is they are testing won't kill all the mice.
But supposedly "It has been WELL ESTABLISHED in the scientific community that animal studies don't seem to correlate the same results with humans."
Science tries it's best to observe and create hypothesis if a test is done on an animal and how it MAY affect a human.
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ParadigmShifter wrote: »
It has been WELL ESTABLISHED in the scientific community that animal studies don't seem to correlate the same results with humans.GaleHawkins wrote: »Marigolds333 wrote: »
https://youtu.be/dBnniua6-oM
Sugar, The Bitter Truth.. This is about an hour long , but VERY worth watching. Very informative.
@Marigolds333 below is some research that drives home the validity of video that you posted by addressing that High Fructose can lead to IR which we know makes weight loss much harder.
https://ncbi.nlm.nih.gov/pubmed/27025195
Pancreatology. 2016 May-Jun;16(3):347-52. doi: 10.1016/j.pan.2016.03.001. Epub 2016 Mar 10.
Alpha lipoic acid attenuates high-fructose-induced pancreatic toxicity.
Topsakal S1, Ozmen O2, Cankara FN3, Yesilot S4, Bayram D5, Genç Özdamar N6, Kayan S6.
Author information
Abstract
OBJECTIVES:
Chronic consumption of high-fructose corn syrup (HFCS) causes several problems such as insulin resistance. The goal of the study was to investigate pancreatic damage induced by chronic HFCS consumption and the protective effects of alpha lipoic acid (ALA) on pancreatic cells.
METHODS:
Wistar Albino, 4-month-old, female rats weighing 250-300 g were randomly distributed into three groups, each containing eight rats. The study included an HFCS group, an HFCS + ALA-administered group and a control group (CON). The prepared 30% solution of HFCS (F30) (24% fructose, 28% dextrose) was added to the drinking water for 10 weeks. ALA treatment was begun 4 weeks after the first HFCS administration (100 mg/kg/oral, last 6 weeks). Rats were anaesthetised and euthanised by cervical dislocation 24 h after the last ALA administration. Blood samples for biochemical tests (amylase, lipase, malondialdehyde (MDA) and catalase (CAT)) and tissue samples for histopathological and immunohistochemical examinations (caspase-3, insulin and glucagon) were collected.
RESULTS:
Comparing the control and HFCS groups, serum glucose (150.92 ± 39.77 and 236.50 ± 18.28, respectively, p < 0.05), amylase (2165.00 ± 150.76 and 3027.66 ± 729.19, respectively, p < 0.01), lipase (5.58 ± 2.22 and 11.51 ± 2.74, respectively, p < 0.01) and pancreatic tissue MDA (0.0167 ± 0.004 and 0.0193 ± 0.006, respectively, p < 0.05) levels were increased, whereas tissue CAT (0.0924 ± 0.029 and 0.0359 ± 0.023, respectively, p < 0.05) activity decreased in the HFCS group significantly. Histopathological examination revealed degenerative and necrotic changes in Langerhans islet cells and slight inflammatory cell infiltration in pancreatic tissue in the HFCS group. Immunohistochemically there was a significant decrease in insulin (2.85 ± 0.37 and 0.87 ± 0.64, respectively, p < 0.001) and glucagon (2.71 ± 0.48 and 1.00 ± 0.75, respectively, p < 0.001) secreting cell scores, whereas a greater increase in caspase-3 (0.14 ± 0.37 and 1.00 ± 0.75, respectively, p < 0.05) expression was seen in this group compared with the controls. In the ALA-treated group, all of these pathologic conditions were improved.
CONCLUSIONS:
This study indicated HFCS induced pancreatic lesions, but ALA had ameliorative effects.
Copyright © 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Alpha lipoic acid; High-fructose corn syrup; Immunohistochemistry; Oxidative stress; Pancreas; Pathology
PMID: 27025195 DOI: 10.1016/j.pan.2016.03.001
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Then why even do studies on animals?
It's cheap and you can experiment on hundreds of subjects in minimal space.3 -
ParadigmShifter wrote: »ParadigmShifter wrote: »
Then why even do studies on animals?
Because they can't do any human studies until they prove that whatever it is they are testing won't kill all the mice.
But supposedly "It has been WELL ESTABLISHED in the scientific community that animal studies don't seem to correlate the same results with humans."
True, but critters are the only thing available until safety is proven. Once safety is shown, they can then progress to humans to test efficacy.2 -
ParadigmShifter wrote: »ParadigmShifter wrote: »
Then why even do studies on animals?
Because they can't do any human studies until they prove that whatever it is they are testing won't kill all the mice.
But supposedly "It has been WELL ESTABLISHED in the scientific community that animal studies don't seem to correlate the same results with humans."
This depends on what you are studying - if gastrointestinal - then swine, if vasculature - then rabbit, etc. Animal studies give a preclinical team understanding on how a specific drug, marker, device will behave. Based on this information then the study is expanded to human population.
The obvious problem with humans is that you lose control of the variables and can only track behavior within the clinic. This is compounded with any issue that is linked to behavior, such as weight management.4 -
stevencloser wrote: »RuNaRoUnDaFiEld wrote: »CharlieBeansmomTracey wrote: »CharlieBeansmomTracey wrote: »Tazzie0208 wrote: »Sugar is not to be omitted from your diet. Your brain needs sugar. We function with the help of sugar. What needs to be done is as we all know, follow a balanced diet. Everything in moderation. Be mindful. That is all.
No your body doesn't need sugar. It doesn't need carbs at all, for that matter (and a few people manage to function just fine with a diet containing virtually no carbs) (not me!). the body can make everything it needs from fats and proteins.
so then how does one get the nutrients they need that fruits and veggies provide? those things are carbs(sugar)
I think they mean that dietary sugar or carbs are not needed, which is true.
... I think my carb total for this month during an animal products challenge is about 30g. Carbs definitely haven't been needed.
they may not be needed to function, but if you cut out fruits and veggies would you not be denying your body of certain nutrients only those things can provide? how is the body going to make certain nutrients from fats and protein if the food doesnt contain it?
All nutrients are available in animal products. Some are actually more bio available in that form.
Fibre is about the only thing that is missing but it is really only a benefit when digesting plant matter. It is not needed for a animal based diet.
You have to eat offal to get the full spectrum though don't you?
No, but that does make it much easier. Sort of like how spinach is a better source of calcium than carrots but you don't need to eat spinach to get calcium (if a vegetarian).
Not overcooking meat helps too.
It's funny you should mention calcium.
Meat is almost devoid of calcium.
If you include eggs and dairy, you will need to drink about a liter of milk a day for your calcium. Fine, that's possible.
You'll still be lacking Vitamin C and Manganese first and foremost and probably some other things I didn't see at first glance.
RDA's are set up for people who eat SAD.
Vitamin C recommendations are ridiculously high for those who have removed refined foods from their diet.
Calcium? There is a lot of calcium in animal products. Drink bone broth, eat cheese, eat fish... The muscle of the animal is not the only animal product out there that people eat. Dairy is not the only source of calcium out there, nor is it the best. Plus the K2 and D in animal products tends to aid with Ca absorption more than what you'd get in plant products.
For manganese, a trace mineral, it is in animal products, especially those that are raised in a more natural manner like grass fed beef. Shell fish are fairly high in manganese too.
And for those who like ofal, or like to incorporate it into food, that is a very high source of many vitamins and minerals. My point was that it is not a necessary source of vitamins and minerals for people who eat largely carnivorous. Just like collard greens are not mandatory for vegetarians. Both are helpful but not crucial to good health.stevencloser wrote: »RuNaRoUnDaFiEld wrote: »CharlieBeansmomTracey wrote: »CharlieBeansmomTracey wrote: »Tazzie0208 wrote: »Sugar is not to be omitted from your diet. Your brain needs sugar. We function with the help of sugar. What needs to be done is as we all know, follow a balanced diet. Everything in moderation. Be mindful. That is all.
No your body doesn't need sugar. It doesn't need carbs at all, for that matter (and a few people manage to function just fine with a diet containing virtually no carbs) (not me!). the body can make everything it needs from fats and proteins.
so then how does one get the nutrients they need that fruits and veggies provide? those things are carbs(sugar)
I think they mean that dietary sugar or carbs are not needed, which is true.
... I think my carb total for this month during an animal products challenge is about 30g. Carbs definitely haven't been needed.
they may not be needed to function, but if you cut out fruits and veggies would you not be denying your body of certain nutrients only those things can provide? how is the body going to make certain nutrients from fats and protein if the food doesnt contain it?
All nutrients are available in animal products. Some are actually more bio available in that form.
Fibre is about the only thing that is missing but it is really only a benefit when digesting plant matter. It is not needed for a animal based diet.
You have to eat offal to get the full spectrum though don't you?
Yep. Raw meat and/or organs on the regular.
This isn't true of many healthy carnivores. Some eat it but it isn't needed.
RDAs are not based on the SAD diet. They are derived by the requirements that people need to achieve good health. SAD is the polar opposite of that.
I disagree. RDA is set up for the typical person eating a SAD diet. Nutrient intake and absorption/usage can vary based upon foods.
Where are you getting this from?0 -
ParadigmShifter wrote: »ParadigmShifter wrote: »
Then why even do studies on animals?
Because they can't do any human studies until they prove that whatever it is they are testing won't kill all the mice.
But supposedly "It has been WELL ESTABLISHED in the scientific community that animal studies don't seem to correlate the same results with humans."
In some cases animals are used because it wold be unethical to do the same things to people (intentional infection, as an example).3 -
The best meat that gives the most nutrition is long pig aka canabalism. But then you'd risk being infected by brain eating prions as well as being arrested.stevencloser wrote: »RuNaRoUnDaFiEld wrote: »CharlieBeansmomTracey wrote: »CharlieBeansmomTracey wrote: »Tazzie0208 wrote: »Sugar is not to be omitted from your diet. Your brain needs sugar. We function with the help of sugar. What needs to be done is as we all know, follow a balanced diet. Everything in moderation. Be mindful. That is all.
No your body doesn't need sugar. It doesn't need carbs at all, for that matter (and a few people manage to function just fine with a diet containing virtually no carbs) (not me!). the body can make everything it needs from fats and proteins.
so then how does one get the nutrients they need that fruits and veggies provide? those things are carbs(sugar)
I think they mean that dietary sugar or carbs are not needed, which is true.
... I think my carb total for this month during an animal products challenge is about 30g. Carbs definitely haven't been needed.
they may not be needed to function, but if you cut out fruits and veggies would you not be denying your body of certain nutrients only those things can provide? how is the body going to make certain nutrients from fats and protein if the food doesnt contain it?
All nutrients are available in animal products. Some are actually more bio available in that form.
Fibre is about the only thing that is missing but it is really only a benefit when digesting plant matter. It is not needed for a animal based diet.
You have to eat offal to get the full spectrum though don't you?
Yep. Raw meat and/or organs on the regular.
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