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Diabetes drug significantly cuts body weight in adults with obesity
Dante_80
Posts: 480 Member
Read this interesting article the other day, wanted to share. I've been prescribed a similar drug due to - now waning - type 2 diabetes (Victosa, using liraglutide instead), and I think it has also helped me somewhat curb my appetite, especially in the evenings (I've been on a weight loss journey for close to 10 months now, having shed around 125lbs so far).
Could this become another good tool in conjuction with nutrition and exercise to stem the obesity epidemic?
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Diabetes drug significantly cuts body weight in adults with obesity
A Phase 3 clinical trial published in The New England Journal of Medicine demonstrated an average 14.9% decrease in body weight in adults with obesity or overweight who received an injectable diabetes medication, semaglutide, in addition to lifestyle interventions.
Approximately 50% of the participants in the semaglutide group achieved significant weight reductions of 15% or more, while 69% of participants achieved 10% or more, and 86% of participants achieved 5% or more.
The trial showed reductions in risk factors for diabetes and heart disease and a greater self-reported physical functioning in participants receiving semaglutide.
Obesity is a prevalent and serious health concern, both in the United States and globally. The Centers for Disease Control and Prevention (CDC) report that the prevalence of obesity in the U.S. increased substantially from 30.5% in 1999–2000 to 42.4% in 2017–2018, with severe obesity rising from 4.7% to 9.2%.
Doctors often use body mass index (BMI) — which a person can calculate by dividing their weight in kilograms (kg) by the square of their height in meters — to determine whether a person’s weight is healthy. A BMI of 25 to <30 falls within the overweight range in adults, while those with obesity have a BMI of ≥30.
A serious health concern
Obesity reduces life expectancy and is a major risk factor for cardiovascular disease, type 2 diabetes, non-alcohol-related fatty liver disease, and certain cancers, including breast, ovarian, endometrial, prostate, liver, and colon cancer.
Currently, a combination of diet and exercise is the mainstay of obesity treatment. If these lifestyle interventions prove ineffective over 6 months, clinical guidelines recommend medications for people with a BMI of ≥30 or those with a BMI of ≥27 who have other related health conditions.
Effectiveness, cost, and safety issues limit the use of currently available medications. Injectable semaglutide is a drug that the Food and Drug Administration (FDA) have approved for adults with type 2 diabetes and cardiovascular disease.
Semaglutide is an analog of the naturally occurring human glucagon-like peptide-1 (GLP-1) hormone in the body. The body releases GLP-1 from the gut into the bloodstream after meals, increasing satiety and reducing hunger and cravings.
In a phase 2 clinical trial involving adults with type 2 diabetes and obesity, injectable semaglutide treatment resulted in weight loss.
This result led investigators to conduct a global phase 3 trial called Semaglutide Treatment Effect in People with Obesity (STEP) to investigate the safety and effectiveness of semaglutide in participants aged 18 years and older.
The participants had either a BMI of ≥30 or a BMI of ≥27 and weight-related health conditions. A group of the participants received a placebo instead of the treatment.
The trial excluded people who had diabetes, had previously undergone obesity surgery, or had used medications to treat obesity in the 90 days before enrollment. However, the participants had some weight-related health conditions, including hypertension, high cholesterol, obstructive sleep apnea, and cardiovascular disease.
The researchers randomly assigned a total of 1,961 participants to receive either semaglutide (as an injection under the skin with a dose of 2.4 milligrams) or placebo, with both groups also receiving lifestyle interventions.
Over 68 weeks, 1,306 participants received semaglutide and 655 participants received the placebo on a weekly basis.
At baseline, the average body weight was 105.3 kg, the average age was 46 years, and the average BMI was 37.9. In addition, 75% of the participants had at least one coexisting condition.
‘Game-changing’ findings
On average, participants in the semaglutide group significantly decreased their body weight by 14.9% (-15.3 kg) from baseline compared with 2.4% (-2.6 kg) in the placebo group.
The trial demonstrated significant weight reductions of:
5% or more in 86.4% of participants in the semaglutide group vs. 31.5% in the placebo group
10% or more in 69.1% of participants in the semaglutide group vs. 12% in the placebo group
15% or more in 50.5% of participants in the semaglutide group vs. 4.9% in the placebo group
Study participants receiving semaglutide also had greater reductions in waist circumference, blood pressure, fasting lipid levels, and blood glucose than those receiving the placebo. In addition, they had increased self-reported physical functioning scores.
The most common adverse effects included mild-to-moderate nausea and diarrhea that usually subsided with time. More participants stopped treatment due to gastrointestinal side effects in the semaglutide group (4.5%) than in the placebo group (0.8%).
Study limitations
The trial had some limitations, including its short duration and the exclusion of people with diabetes.
The majority of the participants were white (75.1%) and female (74.1%) and, therefore, not reflective of the general population with obesity. This limits the generalizability of the findings.
Additionally, people with a phobia of needles may not wish to use an injectable drug in the long term.
One of the main authors of the study, Rachel Batterham, M.B., B.S., Ph.D., a professor of obesity, diabetes, and endocrinology at the Centre for Obesity Research at University College London (UCL) and the UCL Hospitals Centre for Weight Management, comments on the findings:
“No other drug has come close to producing this level of weight loss — this really is a gamechanger. For the first time, people can achieve through drugs what was only possible through weight loss surgery.”
Based on these trial results, Novo Nordisk, the pharmaceutical company funding the clinical trial, submitted a request for regulatory approval for injectable semaglutide to treat obesity to the FDA, the European Medicines Agency, and the National Institute for Health and Care Excellence.
Although the trial results seem promising, head-to-head trials comparing semaglutide with other standard-of-care pharmacologic and surgical treatment options will be necessary to determine its eventual role in treatment.
Dr. Batterham adds, “The impact of obesity on health has been brought into sharp focus by COVID-19, where obesity markedly increases the risk of dying from the virus, as well as increasing the risk of many life limiting serious diseases, including heart disease, type 2 diabetes, liver disease, and certain types of cancers.”
“This drug could have major implications for U.K. health policy for years to come.”
Source:. https://www.medicalnewstoday.com/articles/diabetes-drug-significantly-cuts-body-weight-in-adults-with-obesity
Could this become another good tool in conjuction with nutrition and exercise to stem the obesity epidemic?
---
Diabetes drug significantly cuts body weight in adults with obesity
A Phase 3 clinical trial published in The New England Journal of Medicine demonstrated an average 14.9% decrease in body weight in adults with obesity or overweight who received an injectable diabetes medication, semaglutide, in addition to lifestyle interventions.
Approximately 50% of the participants in the semaglutide group achieved significant weight reductions of 15% or more, while 69% of participants achieved 10% or more, and 86% of participants achieved 5% or more.
The trial showed reductions in risk factors for diabetes and heart disease and a greater self-reported physical functioning in participants receiving semaglutide.
Obesity is a prevalent and serious health concern, both in the United States and globally. The Centers for Disease Control and Prevention (CDC) report that the prevalence of obesity in the U.S. increased substantially from 30.5% in 1999–2000 to 42.4% in 2017–2018, with severe obesity rising from 4.7% to 9.2%.
Doctors often use body mass index (BMI) — which a person can calculate by dividing their weight in kilograms (kg) by the square of their height in meters — to determine whether a person’s weight is healthy. A BMI of 25 to <30 falls within the overweight range in adults, while those with obesity have a BMI of ≥30.
A serious health concern
Obesity reduces life expectancy and is a major risk factor for cardiovascular disease, type 2 diabetes, non-alcohol-related fatty liver disease, and certain cancers, including breast, ovarian, endometrial, prostate, liver, and colon cancer.
Currently, a combination of diet and exercise is the mainstay of obesity treatment. If these lifestyle interventions prove ineffective over 6 months, clinical guidelines recommend medications for people with a BMI of ≥30 or those with a BMI of ≥27 who have other related health conditions.
Effectiveness, cost, and safety issues limit the use of currently available medications. Injectable semaglutide is a drug that the Food and Drug Administration (FDA) have approved for adults with type 2 diabetes and cardiovascular disease.
Semaglutide is an analog of the naturally occurring human glucagon-like peptide-1 (GLP-1) hormone in the body. The body releases GLP-1 from the gut into the bloodstream after meals, increasing satiety and reducing hunger and cravings.
In a phase 2 clinical trial involving adults with type 2 diabetes and obesity, injectable semaglutide treatment resulted in weight loss.
This result led investigators to conduct a global phase 3 trial called Semaglutide Treatment Effect in People with Obesity (STEP) to investigate the safety and effectiveness of semaglutide in participants aged 18 years and older.
The participants had either a BMI of ≥30 or a BMI of ≥27 and weight-related health conditions. A group of the participants received a placebo instead of the treatment.
The trial excluded people who had diabetes, had previously undergone obesity surgery, or had used medications to treat obesity in the 90 days before enrollment. However, the participants had some weight-related health conditions, including hypertension, high cholesterol, obstructive sleep apnea, and cardiovascular disease.
The researchers randomly assigned a total of 1,961 participants to receive either semaglutide (as an injection under the skin with a dose of 2.4 milligrams) or placebo, with both groups also receiving lifestyle interventions.
Over 68 weeks, 1,306 participants received semaglutide and 655 participants received the placebo on a weekly basis.
At baseline, the average body weight was 105.3 kg, the average age was 46 years, and the average BMI was 37.9. In addition, 75% of the participants had at least one coexisting condition.
‘Game-changing’ findings
On average, participants in the semaglutide group significantly decreased their body weight by 14.9% (-15.3 kg) from baseline compared with 2.4% (-2.6 kg) in the placebo group.
The trial demonstrated significant weight reductions of:
5% or more in 86.4% of participants in the semaglutide group vs. 31.5% in the placebo group
10% or more in 69.1% of participants in the semaglutide group vs. 12% in the placebo group
15% or more in 50.5% of participants in the semaglutide group vs. 4.9% in the placebo group
Study participants receiving semaglutide also had greater reductions in waist circumference, blood pressure, fasting lipid levels, and blood glucose than those receiving the placebo. In addition, they had increased self-reported physical functioning scores.
The most common adverse effects included mild-to-moderate nausea and diarrhea that usually subsided with time. More participants stopped treatment due to gastrointestinal side effects in the semaglutide group (4.5%) than in the placebo group (0.8%).
Study limitations
The trial had some limitations, including its short duration and the exclusion of people with diabetes.
The majority of the participants were white (75.1%) and female (74.1%) and, therefore, not reflective of the general population with obesity. This limits the generalizability of the findings.
Additionally, people with a phobia of needles may not wish to use an injectable drug in the long term.
One of the main authors of the study, Rachel Batterham, M.B., B.S., Ph.D., a professor of obesity, diabetes, and endocrinology at the Centre for Obesity Research at University College London (UCL) and the UCL Hospitals Centre for Weight Management, comments on the findings:
“No other drug has come close to producing this level of weight loss — this really is a gamechanger. For the first time, people can achieve through drugs what was only possible through weight loss surgery.”
Based on these trial results, Novo Nordisk, the pharmaceutical company funding the clinical trial, submitted a request for regulatory approval for injectable semaglutide to treat obesity to the FDA, the European Medicines Agency, and the National Institute for Health and Care Excellence.
Although the trial results seem promising, head-to-head trials comparing semaglutide with other standard-of-care pharmacologic and surgical treatment options will be necessary to determine its eventual role in treatment.
Dr. Batterham adds, “The impact of obesity on health has been brought into sharp focus by COVID-19, where obesity markedly increases the risk of dying from the virus, as well as increasing the risk of many life limiting serious diseases, including heart disease, type 2 diabetes, liver disease, and certain types of cancers.”
“This drug could have major implications for U.K. health policy for years to come.”
Source:. https://www.medicalnewstoday.com/articles/diabetes-drug-significantly-cuts-body-weight-in-adults-with-obesity
5
Replies
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I guess it could become a good tool. I don't think it is a magic bullet, though. People over-consume calories for all sorts of reasons, not just because they are hungry. My husband is obese because he has drunk vast quantities of beer over his lifetime. He doesn't eat all that much. Reducing his appetite alone would have little effect on his weight. People seem willing and able to sabotage their gastric band surgery by finding ways to consume more calories than they should.13
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1. What are the side effects of this drugs
2. What are the side of effects of exercising and not overeating
Although #2 is hard work, I would much prefer that to what the side effects of what #1 would be11 -
Side effects do matter. Phen Phen worked. It also killed people who weren't aware of the side effects.
Weight loss is one of the one things that people are willing to chance with their lives for vanity reasons many times. Even people who are just a little overweight will chance a drug rather than do the real work to get it done.
A.C.E. Certified Personal and Group Fitness Trainer
IDEA Fitness member
Kickboxing Certified Instructor
Been in fitness for 30 years and have studied kinesiology and nutrition
13 -
I just started using Ozempic, which is a semaglutide, and started a group discussion on this site about experiences from the patients' perspective. I'm generally skeptical of miracle weight loss solutions, but am a pre-diabetic with cardiovascular issues and, ahem, some extra pounds due to COVID inactivity and boredom eating. My doctor recommended this and my insurance pays for it, so I'm giving it a try. We'll see. Check out my Ozempic group if you have something to contribute or want to hear more.9
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Diabetes medications come in a few "classes" (or types) and many of them have a weight loss effect as a side effect (an adverse event - positive or negative - seeing as this is often not their primary purpose).
Clinical study or nah, a discussion with your prescribing physician about whether this kind of approach is appropriate for one's weight loss goals (and lifestyle), is needed.5 -
Below is the mechanismSemaglutide acts like human glucagon-like peptide-1 (GLP-1) so that it increases insulin secretion, thereby increasing sugar metabolism.4
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I just started Saxenda on 4/2/21. I started with blood work, doctor consultation and a health coach to get me on track to better habits 3 weeks before starting. Saxenda + lifestyle changes is working out really well for me. I'm down 4 lbs in 5 days. I know it's mostly water weight but it's a promising start.3
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Don't let the perfect be the enemy of the good, people.Side effects do matter.
Does obesity have side effects or bad health outcomes?
We both know that obesity related ailments cut a lot of lives short and reduce the quality of a lot of lives dramatically. We also know obese people are more likely than others to have severe reactions to the coronavirus and they're more likely to need an ICU bed, making it unavailable to someone like my 72 year old mom.
What side effects does this drug have that worry you? It isn't phen phen. Do you think the side effects of this drug are worse than the amputations that become necessary in some T2D cases? (That isn't super common, neither are side effects generally; otherwise they would have been caught and the drug wouldn't have made it to market.)8 -
My concern is what happens when you stop taking the drug? I think most of us have lost and regained at least once because we stopped doing the things that helped us lose weight in the first place. After a several weight loss attempts followed by regains, I finally came to the conclusion that I would never do anything to lose weight that I wasn't willing to maintain for the rest of my life.13
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I started taking metformin with the hopes of weightloss, and then got my dose doubled, and it hasn't made any difference to my weight. My sister took it and lost about 30kg, but I found out later she stopped buying fast food and started eating smaller portions.14
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cyaneverfat wrote: »I started taking metformin with the hopes of weightloss, and then got my dose doubled, and it hasn't made any difference to my weight.
It really can't on its own. The drug helps with blood sugar regulation and satiety. It does not burn fat on its own or reduce your weight in any way.
4 -
cyaneverfat wrote: »I started taking metformin with the hopes of weightloss, and then got my dose doubled, and it hasn't made any difference to my weight.
It really can't on its own. The drug helps with blood sugar regulation and satiety. It does not burn fat on its own or reduce your weight in any way.
I feel like my appetite is smaller? I just might be eating more often.3 -
This content has been removed.
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Obesity and T2D are protective mechanisms the body uses to protect itself from excessive consumption of sugar and carbs.
A medication is NOT the answer. Cutting out / down the poison is the answer.
Sugar and carbs are not a poison. Excessive consumption in any possible macronutrient mix can result in obesity and T2D.21 -
Obesity and T2D are protective mechanisms the body uses to protect itself from excessive consumption of sugar and carbs.
A medication is NOT the answer. Cutting out / down the poison is the answer.
Your advice here would literally kill my husband. No hyperbole.
Also? There are other causes of T2D besides obesity and gluttony.
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I just started using Ozempic, which is a semaglutide, and started a group discussion on this site about experiences from the patients' perspective. I'm generally skeptical of miracle weight loss solutions, but am a pre-diabetic with cardiovascular issues and, ahem, some extra pounds due to COVID inactivity and boredom eating. My doctor recommended this and my insurance pays for it, so I'm giving it a try. We'll see. Check out my Ozempic group if you have something to contribute or want to hear more.
Looking for your group0 -
shortassmax wrote: »I just started using Ozempic, which is a semaglutide, and started a group discussion on this site about experiences from the patients' perspective. I'm generally skeptical of miracle weight loss solutions, but am a pre-diabetic with cardiovascular issues and, ahem, some extra pounds due to COVID inactivity and boredom eating. My doctor recommended this and my insurance pays for it, so I'm giving it a try. We'll see. Check out my Ozempic group if you have something to contribute or want to hear more.
Looking for your group
https://community.myfitnesspal.com/en/group/140032-ozempic-users-for-weight-loss0 -
1. What are the side effects of this drugs
2. What are the side of effects of exercising and not overeating
Although #2 is hard work, I would much prefer that to what the side effects of what #1 would be
But that isn't the equation for people being prescribed Ozempic and co.
The question is what are the side effects of poorly controlled blood sugar vs side effects of the drug.
It isn't a drug for weight loss - it is a drug for type 2 diabetes that has the added benifit of weight loss.5 -
My concern is what happens when you stop taking the drug? I think most of us have lost and regained at least once because we stopped doing the things that helped us lose weight in the first place. After a several weight loss attempts followed by regains, I finally came to the conclusion that I would never do anything to lose weight that I wasn't willing to maintain for the rest of my life.
Well, you mostly don't stop taking it.
Some people can reduce their need for medications if they lose weight and then I guess you would trial weaning down.
But type 2 diabetes is usually a progressive disease so one continues on medication.3 -
Obesity and T2D are protective mechanisms the body uses to protect itself from excessive consumption of sugar and carbs.
A medication is NOT the answer. Cutting out / down the poison is the answer.
Absolutely untrue. Obesity is not a protective mechanism. It is a result of excess calorie intake. Stop with your horrible advice all over these boards.15 -
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Obesity and T2D are protective mechanisms the body uses to protect itself from excessive consumption of sugar and carbs.
A medication is NOT the answer. Cutting out / down the poison is the answer.
Absolutely untrue. Obesity is not a protective mechanism. It is a result of excess calorie intake. Stop with your horrible advice all over these boards.
THANK YOU!4 -
Bumping because I heard about semaglutide elsewhere. I love the idea of an appetite suppressant without cardiovascular concerns, but the side effects sound dreadful, and weekly shots inconvenient.
https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014
For Immediate Release:
June 04, 2021
Today, the U.S. Food and Drug Administration approved Wegovy (semaglutide) injection (2.4 mg once weekly) for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), for use in addition to a reduced calorie diet and increased physical activity. This under-the-skin injection is the first approved drug for chronic weight management in adults with general obesity or overweight since 2014. The drug is indicated for chronic weight management in patients with a body mass index (BMI) of 27 kg/m2 or greater who have at least one weight-related ailment or in patients with a BMI of 30 kg/m2 or greater.
...The most common side effects of Wegovy include nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection) and gastroesophageal reflux disease (a type of digestive disorder).
The prescribing information for Wegovy contains a boxed warning to inform healthcare professionals and patients about the potential risk of thyroid C-cell tumors. Wegovy should not be used in patients with a personal or family history of medullary thyroid carcinoma or in patients with a rare condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Wegovy should not be used in patients with a history of severe allergic reactions to semaglutide or any of the other components of Wegovy. Patients should stop Wegovy immediately and seek medical help if a severe allergic reaction is suspected. Wegovy also contains warnings for inflammation of the pancreas (pancreatitis), gallbladder problems (including gallstones), low blood sugar, acute kidney injury, diabetic retinopathy (damage to the eye's retina), increased heart rate and suicidal behavior or thinking. Patients should discuss with their healthcare professional if they have symptoms of pancreatitis or gallstones. If Wegovy is used with insulin or a substance that causes insulin secretion, patients should speak to their health care provider about potentially lowering the dose of insulin or the insulin-inducing drug to reduce the risk of low blood sugar. Healthcare providers should monitor patients with kidney disease, diabetic retinopathy and depression or suicidal behaviors or thoughts.3 -
You would probably find contraindications for most meds.
As far as I know, it is not prescribed ( not on the PBS anyway) for weight loss here in Australia.
But used sometimes for type 2 diabetes not responding sufficiently to oral meds.
Sure, giving oneself an injection weekly is inconvenient- but by that stage, usually it is that or insulin, which of course is injected more often than weekly.2 -
Oh my...Are you a doctor? If not, maybe stick to nutrition and kickboxing - you have no idea why people ae being prescribed this drug...Side effects do matter. Phen Phen worked. It also killed people who weren't aware of the side effects.
Weight loss is one of the one things that people are willing to chance with their lives for vanity reasons many times. Even people who are just a little overweight will chance a drug rather than do the real work to get it done.
A.C.E. Certified Personal and Group Fitness Trainer
IDEA Fitness member
Kickboxing Certified Instructor
Been in fitness for 30 years and have studied kinesiology and nutrition
9 -
Following this thread. One aspect of it that I'd like to learn more about is the impact of this drug on appetite, and if that is a part of why it seems to work.
Thank you for posting!2 -
A thought about the side effects: if the test subjects were diabetics then retinopathy, kidney disease and low blood sugars are common issues in diabetes. Doubt if the drug worsens them. As for nausea and dizziness they are not uncommon symptoms of low blood sugar. Nausea is also caused by gastroparesis which can be caused by diabetic nerve damage so that the stomach empties slowly. Flatulence is also common when diabetics over consume carbohydrates. I had diagnosed diabetes for over 21 years before receiving a kidney/pancreas transplant. I still suffer from gastroparesis, lost one eye to retinopathy and have experienced all the issues that I mentioned. Please keep in mind that if any person in the test groups experiences a medical issue, the issue is recorded as a side effect whether it is related to the drug or not. Personally, I would have taken this medication if it was available to me.4
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OK, now been on this for just over 9 weeks. Was prescribed for pre-diabetes. Almost 54 and post menopausal, which was when my struggle with losing weight started in all earnest.
Sugar is down to a normal level, I lost 17lbs so far, eating around 1200-1500 calories a day. Moderate workouts (kettlebells ) for 30 mins three times a week and walking 10 000 steps most days. (Workouts halted and walked a lot less for three weeks due to covid)
For all the clever people who would insist that I would have gotten the same results without the drug, please go lift some weights or read a book - you are wrong. I could never eat so litte and stick to this amount of food AND be active before.
My blood pressure is down from hovering around high to normal.
Minimal side effects so far other than the loss of appetite. Some excessive burping when I ate a bit too much, constipation a couple of times but more fibre or a dose of Metamucil took care of that. A bit of nausea right in the beginning, but then I realized I was not eating enough. No real cravings and ate more or less anything I want, just in small amounts.
12 -
1. What are the side effects of this drugs
2. What are the side of effects of exercising and not overeating
Although #2 is hard work, I would much prefer that to what the side effects of what #1 would be
Side effects for me are minimal - some constipation (my own fault as I had too little fibre) and a loss of appetite - whick is the whole idea. More side effects are lower BP, regulated sugar in the normal levels and weight loss.
The side effects of exercising and not overeating for me was getting fitter, a slight lowering or BP and nothing more.... Weight loss would be losing and gaining the same two pounds over and over and over. Even though I was eating "healthy" food in limited quantities, my blood sugar was fluctuating a lot more than what is considered healthy.
When I was in my 20's, 30's and 40's I could work out every day and eat lower calories, lose weight and keep it off. Unfortunately I was just as smug and uninformed as you are, and due to life and injuries getting in the way, I gained a bunch back. Imagine my surprise when the "exercise and not overeating" did not work anymore...
And if you think for one second that using this meds and working out and eating lower calories is not hard work, I suggest you talk to a few more people and maybe try and keep an open mind and learn something in the process.7 -
Hi all,
I have been taking Wegovy for about 3 months now, I have not experienced any positive side effects. Instead, I often find myself nauseous, experiencing regular heartburn, and feeling more tired than normal. My current dose is 1.0 MG' and I have spoken to my doctor yesterday to express my concerns. She has now prescribed Phentermine to kick start my weight loss journey. I am interested to hear how others have responded to this new medication.0
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