I just wish I had it back!!! (Ladies only!)

anemoneprose

ok this is a totally crazy idea. i'm not a doc & have never done depo but i do have a uterus.

keep exercising!

http://en.wikipedia.org/wiki/Medroxyprogesterone_acetate#Pharmacokinetics

MPA is well-absorbed orally and through intramuscular injection, peaking at 2–4 hours for the former. The half life is 12 to 17 hours for an oral dose, and 40 to 50 days (!) for an intramuscular injection. MPA binds to albumin in the blood, and is metabolized primarily through the liver via hydroxylation and conjugation.[3] Intramuscular MPA is released slowly; a 150 mg dose is first detectable in the blood 30 minutes after injection, plateauing at 1.0 ng/mL for three months, followed by a gradual, tapering decline that lasts up to nine months in some women. The high levels of MPA in the blood inhibits luteinizing hormone and ovulation for several months, with an accompanying decrease in serum progesterone to below 0.4 ng/mL. Ovulation resumes when once blood levels of MPA fall below 0.1 ng/ml. Serum estradiol remains at approximately 50 pg/nl for approximately four months post-injection (with a range of 10-92 pg/nL after several years of use), rising once MPA levels fall below 0.5 ng/ml.[32]



*****
http://www.medscape.com/viewarticle/729027_4
Drug Distribution and Exercise


Among several factors, the distribution of drugs to their intended site is dependent on the binding of drugs to plasma proteins.[8] Exercise has been shown to change drug binding to plasma proteins and other tissues. Plasma protein concentrations increase during exercise because of a loss of water from plasma into the tissues.[15,16] As a result, plasma protein concentrations increase, which may influence drug binding to plasma proteins and tissues.[15] In addition, it is theorized that alterations in drug distribution may occur because of redistribution of blood to active muscles, causing an inability of the drug to reach its intended site of action.[15] Several studies have shown that the volume of distribution of drugs such as theophylline, propranolol, acebutolol, oxprenolol, and verapamil change as a result of exercise.[15,17–19]

Additional studies have reported that digoxin binding is altered during exercise.[20–24] Study participants who have taken digoxin for at least 2 weeks and then exercised at various intensities have demonstrated that during exercise, serum digoxin concentration significantly decreases while skeletal muscle concentration significantly increases when compared with resting digoxin levels.[20–24] The clinical significance of these changes were not studied.

http://www.medscape.com/viewarticle/729027_5
Drug Metabolism and Exercise


Drug metabolism is the conversion of the drug to another substance. Some of the factors that affect drug metabolism include blood flow and metabolic enzyme activity. Although drug metabolism can take place in several different organs, the liver has the greatest metabolic capacity and is the organ principally responsible for drug metabolism.[8]

The metabolism of some drugs is highly dependent on the amount of blood flow that occurs through the liver. As discussed previously, blood flow shunted away from the liver during exercise may alter the metabolism of drugs dependent on liver blood flow such as propranolol and verapamil.[8] For other drugs, metabolism is independent of liver blood flow and dependent on metabolic enzyme activity. Physical conditioning can alter metabolic activity and therefore affect drug metabolism. The metabolism of drugs such as carvedilol, insulin, theophylline, and warfarin depend on metabolic enzyme activity. Therefore, it is conceivable that metabolism pharmacokinetics of these types of drugs could change in patients progressing from an untrained to a trained condition and vice versa. There is, however, very little clinical evidence to support this to date.[4]

Pookylou

Hooray for people who actually research medical procedures before actually getting them done!!

For the rest...should have Googled it.

You're a d**k, when you get a vagina then your opinion matters. Have a seat.

'cause men can't know anything about periods/vaginas/women's bodies................? Wow I have been educated today for sure

whierd

ok this is a totally crazy idea. i'm not a doc & have never done depo but i do have a uterus.

keep exercising!

http://en.wikipedia.org/wiki/Medroxyprogesterone_acetate#Pharmacokinetics

MPA is well-absorbed orally and through intramuscular injection, peaking at 2–4 hours for the former. The half life is 12 to 17 hours for an oral dose, and 40 to 50 days (!) for an intramuscular injection. MPA binds to albumin in the blood, and is metabolized primarily through the liver via hydroxylation and conjugation.[3] Intramuscular MPA is released slowly; a 150 mg dose is first detectable in the blood 30 minutes after injection, plateauing at 1.0 ng/mL for three months, followed by a gradual, tapering decline that lasts up to nine months in some women. The high levels of MPA in the blood inhibits luteinizing hormone and ovulation for several months, with an accompanying decrease in serum progesterone to below 0.4 ng/mL. Ovulation resumes when once blood levels of MPA fall below 0.1 ng/ml. Serum estradiol remains at approximately 50 pg/nl for approximately four months post-injection (with a range of 10-92 pg/nL after several years of use), rising once MPA levels fall below 0.5 ng/ml.[32]



http://www.medscape.com/viewarticle/729027_5
Drug Metabolism and Exercise


Drug metabolism is the conversion of the drug to another substance. Some of the factors that affect drug metabolism include blood flow and metabolic enzyme activity. Although drug metabolism can take place in several different organs, the liver has the greatest metabolic capacity and is the organ principally responsible for drug metabolism.[8]

The metabolism of some drugs is highly dependent on the amount of blood flow that occurs through the liver. As discussed previously, blood flow shunted away from the liver during exercise may alter the metabolism of drugs dependent on liver blood flow such as propranolol and verapamil.[8] For other drugs, metabolism is independent of liver blood flow and dependent on metabolic enzyme activity. Physical conditioning can alter metabolic activity and therefore affect drug metabolism. The metabolism of drugs such as carvedilol, insulin, theophylline, and warfarin depend on metabolic enzyme activity. Therefore, it is conceivable that metabolism pharmacokinetics of these types of drugs could change in patients progressing from an untrained to a trained condition and vice versa. There is, however, very little clinical evidence to support this to date.[4]

*faith restored*

anemoneprose

*faith restored*

well, i am an inveterate googler, it's true but i agree that OP probably did want to hear more personal experiences from other women (most of whom do know stuff other than from googling) :flowerforyou: to everyone? (and that idea is kind of kooky)

ElizaRoche

DAMN.. she has the right to ask whatever she wants in here!!!.. Let her be:grumble:

ElizaRoche

*faith restored*

well, i am an inveterate googler, it's true but i agree that OP probably did want to hear more personal experiences from other women (most of whom do know stuff other than from googling) :flowerforyou: to everyone? (and that idea is kind of kooky)

exactly

jackiecamarena

DAMN.. she has the right to ask whatever she wants in here!!!.. Let her be:grumble:

And this is a public forum. Everyone is allowed to respond as well.

MrsFowler1069

Hooray for people who actually research medical procedures before actually getting them done!!

For the rest...should have Googled it.

You're a d**k, when you get a vagina then your opinion matters. Have a seat.

Do you disagree with my opinion?

Also, personal attacks are against the Community Guidelines. If you wish to vent, please keep it to Private Messages.

I meet your anatomical criteria and I think it would have been good to ask these questions prior to accepting the drug. No offense, you know....live and learn or whatever. But even now, with all of the drug information, reviews, interaction information, etc, available on the same Internet as this message board (not to mention her own doctor), I don't feel like this is the best option for gathering the most helpful set of facts. Anecdotal experiences, commence:


ETA: I will still take the option of sitting. I'm tired.

EvgeniZyntx

Just a guy, but I have decision rights on a few uteri.

My daughter wanted DMPA (because her friend took it, and sexually active 15-16 year olds make medical decisions from listening to other girls and not from medical knowledge) and after reviewing the Upjohn/Pizer data and history, plus the number of reported cases of 1, 3, 6 year delays in menstruation post treatment I said no. This is an old drug, first approved in the 60s with really questionable implementation research.

But, as advice to the OP, I can suggest a little more patience - the study I found the most interesting (on Mexican women, because, well, I'm partially Mexican) showed a return at 5.5 months +- 2 months. So wait a little, might be just around the corner.

Just a guy, with uteri.

Edit:Depo is DMPA.

anemoneprose

I meet your anatomical criteria and I think it would have been good to ask these questions prior to accepting the drug. No offense, you know....live and learn or whatever.

sure it'd be ideal if everyone were as obsessive an advocate as it seems one needs to be to get through the medical system, but not everyone happens to be, and i think it's incumbent on docs to maybe not be so cavalier re informed consent when sticking someone with a long-acting drug like that.

& the plural of anecdote is data.

BonnieandClyde29

Just a guy, but I have decision rights on a few uteri.

My daughter wanted DMPA (because her friend took it, and sexually active 15-16 year olds make medical decisions from listening to other girls and not from medical knowledge) and after reviewing the Upjohn/Pizer data and history, plus the number of reported cases of 1, 3, 6 year delays in menstruation post treatment I said no. This is an old drug, first approved in the 60s with really questionable implementation research.

But, as advice to the OP, I can suggest a little more patient - the study I found the most interesting (on Mexican women, because, well, I'm partially Mexican) showed a return at 5.5 months +- 2 months. So wait a little, might be just around the corner.

Just a guy, with uteri.

Edit:Depo is DMPA.

lol it's all good, and yes I got that DMPA is depo thank you, lol.

BonnieandClyde29

whierd..... the girl wants advice from other people with uteri. While your googling skills were just wonderful, you lack the necessary equipment. :flowerforyou:


edit: also,referring to it as a medical procedure seems a little overboard. Its a needle in the butt. But I'm sure google told you that too

Considering how many TOM threads there are, I am not sure she is seeking advice from the proper sources.

A medical procedure is simply what it is. Even an exam is a medical procedure. So I am not exactly sure why you bothered to add that in.

Hooray for people who actually research medical procedures before actually getting them done!!

because this ^^ comment makes it sound like a huge deal, I suppose. Its pointless anyway. If you looked up symptoms for depo (or any hormonal contraceptive) you'd get a list as long as your arm full of contradictory symptoms. Everyone reacts completely differently to it.

Thank you and yes, my body is reacting to it different during and after now, and not like it has before

crb0077

I'm not sure about weight loss/gain etc but I had the shot once....had TOM for 4 months non stop....never ever again!!!!

DemoraFairy

On top of that the forum did say ladies only so thanks for your useless opinion!

when you get a vagina then your opinion matters.

No vagina no comment

Seriously? So I would have a more valid opinion than a male doctor who specialises in this sort of thing just because I'm a girl, even though I've never heard of a depo shot before? Or a guy whose girlfriend has been through this and he knows exactly what happened? I'm not necessarily saying he wasn't being a bit of a **** about it, if she did her research and couldn't find anything then ask away, but saying he shouldn't say anything just because he's a guy is ridiculous. I know OP wanted personal experiences, but experiences can be retold just as well buy a guy who knows the story as by the person it happened to. If you want to criticise his comments then criticise his comments, don't say he's not allowed to make them because he's male.

SarahJane0691

Wow...

I do not agree with saying that if your not male you have no right to comment - at all. The Dr the OP is going to could be male - are we going to disregard anything they say because of gender?! NO.

However the point is the male in question didn't actually offer any constructive comment until he was goaded into it.

lawkat

I did it twice and it messed up my cycle. My doctor put me on the pill form of birth control to get it back to normal again.

neandermagnon

Just a guy, but I have decision rights on a few uteri.

My daughter wanted DMPA (because her friend took it, and sexually active 15-16 year olds make medical decisions from listening to other girls and not from medical knowledge) and after reviewing the Upjohn/Pizer data and history, plus the number of reported cases of 1, 3, 6 year delays in menstruation post treatment I said no. This is an old drug, first approved in the 60s with really questionable implementation research.

But, as advice to the OP, I can suggest a little more patience - the study I found the most interesting (on Mexican women, because, well, I'm partially Mexican) showed a return at 5.5 months +- 2 months. So wait a little, might be just around the corner.

Just a guy, with uteri.

Edit:Depo is DMPA.

you are a great dad :drinker: the world needs more dads who look out for their daughters over stuff like this :drinker:

as for the issue of men commenting on women's reproductive issues, men can be knowledgeable about female issues, and women can be knowledgeable about male issues.

Vivian06703188

So many birth control procedures are dangerous for your health and fertility. This is evidenced by the lawyers commercials on tv suing the manufacturers. I truly feel for your situation because any information you get on the subject is just guess work. There is one thing that you might find helpful. My doctor tells me a persons weight can fluctuate up to 5lbs everyday. So the up and down and all around may not be a gain. You may just be on a plateau. I know this isn't very helpful but it may have nothing to do with the birth control. You should try some different techniques to break the plateau. I truly wish you the best of luck.

mmm_drop

IN. To learn more about TOM because without MFP I would know nothing about reproductive organs and how they work.

robynann1955

I am a woman and I have to agree with the bloke - you cannot restrict replies and this is not a reproductive health forum. And yes googling things always gets a wealth of information - just takes time to fish through it. Your doctor is the person you really should be asking, so glad you have an appointment.