Diet Soda and Weight Loss

daniip_la wrote: »

steph7007 wrote: »

http://m.cancer.org/cancer/cancercauses/othercarcinogens/athome/aspartame

Aaron_k123. I'd like your thoughts on this article. Not meant for haters to bash. I truly would like to broaden my perspective. I believe in healthy eating and good diet choices. Not because I think I know it all. I realize this discussion seems finger pointing. I'm guilty of it in the start of the conversation. But from a biological stand point vs a healthy standpoint..... I really just want to obtain more knowledgeable on this. Again, this is just me wanting his perspective without any negativity from anybody else.

I totally get you are a busy man. If you take a peek... THANK YOU.

If anyone comes at this with the negativity screw you and get a life.

I'm not Aaron_k123, but I know my way around a scientific article. I appreciate you trying to learn more about the matter before making decisions.

I'm curious as to your questions, though. Everything in that link states that there's no harm to aspartame. Was there a particular section in which you didn't feel comfortable about their reasoning?

(this isn't me trying to step on Aaron_k123's toes or answer for him. I just have an interest in helping others understand science as well.)

Aaron_K123 wrote: »

dykask wrote: »

Aaron_K123 wrote: »

dykask wrote: »

Aaron_K123 wrote: »

dykask wrote: »

stevencloser wrote: »

How many more years of research has to flow into the same thing for the last person to be satisfied? The consensus on aspartame is the most confident "ain't nothing wrong with it" I've ever seen in any substance.

Aspartame is far from the only artificial sweetener. Additionally the studies done are have been one sided, both pharmacokinetic and pharmacodynamics studies should be done. The problem is the FDA requirements. But why fear, the US government has never been wrong with diet or drugs!

Out of curiosity what is your familiarity with pharmacokinetic and pharmacodynamic studies? Its a rather odd request for a food additive which is rapidly metabolized and cleared. Kind of like demanding we study the properties of ice on the surface of the sun. For a compound to have measurable PK it has to be able to enter into the blood without being metabolically altered or cleared. So how, exactly, are you picturing a PK study be performed on a methylated dipeptide? Perhaps you can explain what mean and what you expect out of such a study?

ADME PK is typically performed on small molecule drugs which are orally bioavailable and do not undergo rapid metabolism. A is for asbsorption and relates to the ability of the compound to transfer from a mucosal layer such as the intestine into the blood stream for distribution. Aspartame, as an example, is not absorbed into the blood. The M in ADME is for metabolism, related to if the compound is broken down in our body or remains intact. Aspartame, as an example, is rapidly broken down into components of phenylalanine, aspartate and methanol. Di is for distribution, which is the ability of the compound to be distrubuted to different tissues via the blood. For aspartame it is metabolically broken down and not absorbed so there is no "D". E is for excretion, the removal of the compound from the blood to be excreted by the body and works in opposition to distribution. Again, for aspartame, it is metabolically broken down and not absorbed so there is nothing to excrete. Finally PK is the summation of ADME plus seeing what peak levels compound reaches in the blood or in target tissues and how long that is sustained. Of course, in the case of aspartame, can't really do PK given its just immediately broken down.

Aspartame, and the other commonly used artificial sweetners, are metabolically labile and are quickly broken down in our bodies. There is nothing to study in terms of PK so not sure what you are really asking here.

Clearly you have a much deeper knowledge of the this subject area. My comment was from why some doctors say they can't take a position of the artificial sweeteners. At least with some discussions I've listened too. I don't have references because I didn't keep notes about it at the time because my concern was other topics. I can't deeply debate the merits because my background isn't strong. I'm merely accepting the expertise of others.

There literally dozens of artificial sweeteners, although many are uncommon. In my mind the main saving grace of these compounds is that they are typically many times sweeter than even fructose, so very little of the compounds are used. There are even many acute toxins we use routinely with good results. So in fact I'm not overly concerned with the toxicity. However I think it wise to keep an mind open about that. It is becoming widely accepted that fructose is a chronic toxin in the dosage range that is typical in many modern diets. For example in the US many teens are consuming in excess of 50 g/day. I actually think artificial sweeteners offer a safer alternative to refined sugars.

I personally do us a small amount of some artificial sweeteners, although since cutting back on sugar I surprising find myself comsuming much fewer things that contain them. My perception of sweet has been changing. In fact I've found myself being turned off by some things that are just too sweet.

A little background on myself I currently work in drug development and ADME-PK is part of our repitoire for evaluating our compounds so its something I have direct experience with. Medical doctors would not have direct experience with pharmacokinetic studies so that isn't actually within their area of expertise. Its like someone who isn't a mechanic expressing concern that an electric car hasn't been thoroughly smog tested and so until they see data on smog tests for the Tesla they aren't going to purchase one. Pharmacists would probably be much more familiar with the concept of ADME-PK through their studies although again not through the practice of it. The group that would know about it through doing it would be research scientists in areas of drug development. A metabolized food additive isn't something you'd put into an ADME-PK study because there is about as much point in that as trying to smog test a Tesla. You mentioned that you listened to expertise, hopefully you are genuine there and don't mean that you listen to "expertise" only if it conforms to what you have decided to believe anyways. MDs don't have expertise there unless they are MD-PhDs who did some drug development.

You are correct about it being low amounts due to higher sweetness. Aspartame off the top of my head is something like 200 times the sweetness of fructose (I might not remember the exact number). They aren't toxins so you definately don't have to worry about toxicity. People really misuse and overuse the word toxin these days.

"It is becoming widely accepted that fructose is a chronic toxin in the dosage range that is typical in many modern diets" News to me. What is this group (scientific or medical) widely accepts fructose is a "toxin". Fructose doesn't qualify as a toxin because it does not meet the definition of a toxin which is that it has to have acute toxicity. "For example in the US many teens are consuming in excess of 50 g/day." case in point that fructose is not a toxin.

Quick aside just as an FYI. Fructose is a monosaccharide, along with glucose and galactose, fructose being a plant product. Many of the sugars we encounter in our daily lives are disaccharides, two monosaccharides linked together. Lactose is a disaccharide and is the source of sweetness in milk, the sugar found in milk, its galactose and glucose linked together. Sucrose, also a plant product, is also a disaccharide and is what we think of when we think table sugar....its glucose and fructose. You may have seen the name dextrose on ingredient labels, dextrose is just another name for glucose...same thing.

I'm more of a salt-tooth than a sweet-tooth, I like my chocolate dark as they make it. I like sweet beverages though for whatever reason. I flavor my coffee with aspartame typically. Will have a diet coke maybe a couple times a week but thats about it. I'm not trying to push artificial sweetners like they are going to help with people's health, they are a non-entity for me, they neither help nor harm. If you are on a diet and you love your sweet drinks then switching to a diet style drink is a good way to avoid some unneeded calories from a syrup, thats about it.

I very carefully used the term “chronic toxin”. There are different levels of toxicity. Most people only consider something toxic if it is acutely toxic. Many of our over the counter drugs are in the category, but the dosage is typically high for toxic effects and often the effects don't accumulate over time. Chronic toxins are completely on the other end of the spectrum. Often chronic toxin effects accumulate over time and often take decades to do their damage.

The toxic effects of fructose are depended on multiple factors but is mostly driven by how much fructose must be metabolized at a given time. Just how much is too much is a complex question with many variables. Pretty much all fructose is metabolized in the liver or is excreted. The liver has a limited capacity to handle fructose and will handle overloads by converting fructose to low density lipids. This is the same way the ethanol is metabolized, except ethanol can also pass into the brain which isn’t possible with fructose. What happens is the lipids end up being stored in the liver and that becomes a problem in multiple ways. For example uric acid is a by-product of fructose metabolism and it does have toxic properties. The lipids stored in the liver can create a condition called NonAlcoholic Fatty Liver Disease (NAFLD). NAFLD also contributes to Metabolic Syndrome. Finally, even if the lipids make their way out of the liver, they tend to added to the visceral fat, which also contributes to Metabolic Syndrome.

So in short, fructose is a dose dependent hepatic chronic toxin just like ethanol. However, unlike ethanol it doesn’t have the acute toxicity. This relationship possibly exists because ethanol is derived from fructose. (Many people in the world know how to do that.)

NAFLD just like Fatty Liver Disease leads to cirrhosis of the liver. Currently an estimated 25% of the people in the US have NAFLD. http://www.liverfoundation.org/abouttheliver/info/nafld/
Metabolic Syndrome is more complex but is estimated afflict about 1/3 of the US population. Not everyone that is obese has it and it is possible to be slim and have Metabolic Syndrome. http://www.cdc.gov/nchs/data/nhsr/nhsr013.pdf

The cause of NAFLD is too much fructose being processed by the liver. So the number of people having that problem in the US suggests that a large number of people in the US are consuming fructose at high enough levels to encounter toxic effects from that consumption.

While the toxicity of fructose was controversial in the past it is currently more widely accepted. The controversy started well over 200 years ago. Science is catching up with the controversy. However there haven’t been any well-established links between artificial sweeteners and NAFLD or Metabolic Syndrome. (Many have tried to establish links.)

I feel at this point its important to back up and define some terms.

Toxin has a definition and I feel like you, and many members of the public, are misusing it and changing its meaning.

A toxin, by definition, is a metabolic product of a living organism (animal, plant, bacterium) that has an acute toxic affect to another organism. Toxins are also typically antigenic and trigger antibody production. If a compound doesn't meet that definition it is not a toxin. Arsenic is acutely toxic, however it is not the metabolic product of a living organism it is an element and therefore it is not a toxin. Tar produced by tabacco plants can leave residues that over time can increase risk of harm in the form of cancer by causing damage to your lung, but its not acutely toxic...so its not a toxin. You stating that you carefully stated "chronic toxin" does not somehow mean you aren't misusing the term. If we were talking about the damages of poverty on society and you started talking about the difficulties billionaires face and I pointed out that billionaires aren't poor and you came back saying "I carefully stated 'poor billionaires' " that doesn't suddenly mean you are now making sense." There are no poor billionaires...there are no chronic toxins. There is such a thing as chronic toxicity however you must understand the word toxin does not mean "anything that is toxic".

The bacterium vibro cholera produces a molecule that causes damage to the cell membrane of cells in your intestine rupturing and killing them in quick order. That is a toxin.

Fructose is not a toxin by the definition of the word toxin. Aspartame is not a toxin by the definition of the word toxin. Small molecules used as drugs produced in labs are not toxins by the definition of the word toxin.

People are just taking toxin to mean "anything that is toxic" and that is NOT the definition of the word at all, people are just misuing it.

So what do you mean when you say toxin? Do you mean "anything that can possibly cause us harm" because that seems to be the way you are using it. In that sense sure, any sugar is a toxin...oxygen is a toxin, anything we injest is a toxin because metabolic products of it cause us repairable damage that, although repairable, over long periods of time tear us down and increase our chance of cancer or chronic diseases.

Fructose, in the form of high fructose corn syrup, as a processed product no doubt has a lot to do with the ease at which American's become obese with their diets. That doesn't make fructose a "toxin". Words have meaning and we should use those words only when their meaning applies. Saying "chronic toxin" is like saying "poor billionaire" its antithetical to the very meaning of the word. Toxins, by definition of the word, have high toxicity at low concentrations in an acute fashion. If I am somehow mistaken please find a scientific publication or a scientific organization (such as the CDC) refering to a "chronic toxin" or something that is not a living organisms organic product as a toxin or something that causes damage only over the long term as a toxin and link to it. Do note you might find a phrase such as "chronic toxin exposure" but the chronic refers to the exposure not the toxin itself, so be careful.

Can look up cholera toxin as a cannonical example of a toxin, specifically a type of toxin known as an enterotoxin. BT, a pesticide, is also an enterotoxin but it only affects certain insects. Another property of toxins by the way, they tend to be organism specific. Cholera toxin wouldn't affect those insects.

I know I am repeating myself but I want to say this again for emphasis to anyone reading. Toxin DOES NOT MEAN "anything that is toxic". Toxic and toxin, despite how similar they look, are very different words.

Aaron_K123 wrote: »

dykask wrote: »

Aaron_K123 wrote: »

dykask wrote: »

Aaron_K123 wrote: »

dykask wrote: »

Aaron_K123 wrote: »

dykask wrote: »

stevencloser wrote: »

How many more years of research has to flow into the same thing for the last person to be satisfied? The consensus on aspartame is the most confident "ain't nothing wrong with it" I've ever seen in any substance.

Aspartame is far from the only artificial sweetener. Additionally the studies done are have been one sided, both pharmacokinetic and pharmacodynamics studies should be done. The problem is the FDA requirements. But why fear, the US government has never been wrong with diet or drugs!

Out of curiosity what is your familiarity with pharmacokinetic and pharmacodynamic studies? Its a rather odd request for a food additive which is rapidly metabolized and cleared. Kind of like demanding we study the properties of ice on the surface of the sun. For a compound to have measurable PK it has to be able to enter into the blood without being metabolically altered or cleared. So how, exactly, are you picturing a PK study be performed on a methylated dipeptide? Perhaps you can explain what mean and what you expect out of such a study?

ADME PK is typically performed on small molecule drugs which are orally bioavailable and do not undergo rapid metabolism. A is for asbsorption and relates to the ability of the compound to transfer from a mucosal layer such as the intestine into the blood stream for distribution. Aspartame, as an example, is not absorbed into the blood. The M in ADME is for metabolism, related to if the compound is broken down in our body or remains intact. Aspartame, as an example, is rapidly broken down into components of phenylalanine, aspartate and methanol. Di is for distribution, which is the ability of the compound to be distrubuted to different tissues via the blood. For aspartame it is metabolically broken down and not absorbed so there is no "D". E is for excretion, the removal of the compound from the blood to be excreted by the body and works in opposition to distribution. Again, for aspartame, it is metabolically broken down and not absorbed so there is nothing to excrete. Finally PK is the summation of ADME plus seeing what peak levels compound reaches in the blood or in target tissues and how long that is sustained. Of course, in the case of aspartame, can't really do PK given its just immediately broken down.

Aspartame, and the other commonly used artificial sweetners, are metabolically labile and are quickly broken down in our bodies. There is nothing to study in terms of PK so not sure what you are really asking here.

Clearly you have a much deeper knowledge of the this subject area. My comment was from why some doctors say they can't take a position of the artificial sweeteners. At least with some discussions I've listened too. I don't have references because I didn't keep notes about it at the time because my concern was other topics. I can't deeply debate the merits because my background isn't strong. I'm merely accepting the expertise of others.

There literally dozens of artificial sweeteners, although many are uncommon. In my mind the main saving grace of these compounds is that they are typically many times sweeter than even fructose, so very little of the compounds are used. There are even many acute toxins we use routinely with good results. So in fact I'm not overly concerned with the toxicity. However I think it wise to keep an mind open about that. It is becoming widely accepted that fructose is a chronic toxin in the dosage range that is typical in many modern diets. For example in the US many teens are consuming in excess of 50 g/day. I actually think artificial sweeteners offer a safer alternative to refined sugars.

I personally do us a small amount of some artificial sweeteners, although since cutting back on sugar I surprising find myself comsuming much fewer things that contain them. My perception of sweet has been changing. In fact I've found myself being turned off by some things that are just too sweet.

A little background on myself I currently work in drug development and ADME-PK is part of our repitoire for evaluating our compounds so its something I have direct experience with. Medical doctors would not have direct experience with pharmacokinetic studies so that isn't actually within their area of expertise. Its like someone who isn't a mechanic expressing concern that an electric car hasn't been thoroughly smog tested and so until they see data on smog tests for the Tesla they aren't going to purchase one. Pharmacists would probably be much more familiar with the concept of ADME-PK through their studies although again not through the practice of it. The group that would know about it through doing it would be research scientists in areas of drug development. A metabolized food additive isn't something you'd put into an ADME-PK study because there is about as much point in that as trying to smog test a Tesla. You mentioned that you listened to expertise, hopefully you are genuine there and don't mean that you listen to "expertise" only if it conforms to what you have decided to believe anyways. MDs don't have expertise there unless they are MD-PhDs who did some drug development.

You are correct about it being low amounts due to higher sweetness. Aspartame off the top of my head is something like 200 times the sweetness of fructose (I might not remember the exact number). They aren't toxins so you definately don't have to worry about toxicity. People really misuse and overuse the word toxin these days.

"It is becoming widely accepted that fructose is a chronic toxin in the dosage range that is typical in many modern diets" News to me. What is this group (scientific or medical) widely accepts fructose is a "toxin". Fructose doesn't qualify as a toxin because it does not meet the definition of a toxin which is that it has to have acute toxicity. "For example in the US many teens are consuming in excess of 50 g/day." case in point that fructose is not a toxin.

Quick aside just as an FYI. Fructose is a monosaccharide, along with glucose and galactose, fructose being a plant product. Many of the sugars we encounter in our daily lives are disaccharides, two monosaccharides linked together. Lactose is a disaccharide and is the source of sweetness in milk, the sugar found in milk, its galactose and glucose linked together. Sucrose, also a plant product, is also a disaccharide and is what we think of when we think table sugar....its glucose and fructose. You may have seen the name dextrose on ingredient labels, dextrose is just another name for glucose...same thing.

I'm more of a salt-tooth than a sweet-tooth, I like my chocolate dark as they make it. I like sweet beverages though for whatever reason. I flavor my coffee with aspartame typically. Will have a diet coke maybe a couple times a week but thats about it. I'm not trying to push artificial sweetners like they are going to help with people's health, they are a non-entity for me, they neither help nor harm. If you are on a diet and you love your sweet drinks then switching to a diet style drink is a good way to avoid some unneeded calories from a syrup, thats about it.

I very carefully used the term “chronic toxin”. There are different levels of toxicity. Most people only consider something toxic if it is acutely toxic. Many of our over the counter drugs are in the category, but the dosage is typically high for toxic effects and often the effects don't accumulate over time. Chronic toxins are completely on the other end of the spectrum. Often chronic toxin effects accumulate over time and often take decades to do their damage.

The toxic effects of fructose are depended on multiple factors but is mostly driven by how much fructose must be metabolized at a given time. Just how much is too much is a complex question with many variables. Pretty much all fructose is metabolized in the liver or is excreted. The liver has a limited capacity to handle fructose and will handle overloads by converting fructose to low density lipids. This is the same way the ethanol is metabolized, except ethanol can also pass into the brain which isn’t possible with fructose. What happens is the lipids end up being stored in the liver and that becomes a problem in multiple ways. For example uric acid is a by-product of fructose metabolism and it does have toxic properties. The lipids stored in the liver can create a condition called NonAlcoholic Fatty Liver Disease (NAFLD). NAFLD also contributes to Metabolic Syndrome. Finally, even if the lipids make their way out of the liver, they tend to added to the visceral fat, which also contributes to Metabolic Syndrome.

So in short, fructose is a dose dependent hepatic chronic toxin just like ethanol. However, unlike ethanol it doesn’t have the acute toxicity. This relationship possibly exists because ethanol is derived from fructose. (Many people in the world know how to do that.)

NAFLD just like Fatty Liver Disease leads to cirrhosis of the liver. Currently an estimated 25% of the people in the US have NAFLD. http://www.liverfoundation.org/abouttheliver/info/nafld/
Metabolic Syndrome is more complex but is estimated afflict about 1/3 of the US population. Not everyone that is obese has it and it is possible to be slim and have Metabolic Syndrome. http://www.cdc.gov/nchs/data/nhsr/nhsr013.pdf

The cause of NAFLD is too much fructose being processed by the liver. So the number of people having that problem in the US suggests that a large number of people in the US are consuming fructose at high enough levels to encounter toxic effects from that consumption.

While the toxicity of fructose was controversial in the past it is currently more widely accepted. The controversy started well over 200 years ago. Science is catching up with the controversy. However there haven’t been any well-established links between artificial sweeteners and NAFLD or Metabolic Syndrome. (Many have tried to establish links.)

I feel at this point its important to back up and define some terms.

Toxin has a definition and I feel like you, and many members of the public, are misusing it and changing its meaning.

A toxin, by definition, is a metabolic product of a living organism (animal, plant, bacterium) that has an acute toxic affect to another organism. Toxins are also typically antigenic and trigger antibody production. If a compound doesn't meet that definition it is not a toxin. Arsenic is acutely toxic, however it is not the metabolic product of a living organism it is an element and therefore it is not a toxin. Tar produced by tabacco plants can leave residues that over time can increase risk of harm in the form of cancer by causing damage to your lung, but its not acutely toxic...so its not a toxin. You stating that you carefully stated "chronic toxin" does not somehow mean you aren't misusing the term. If we were talking about the damages of poverty on society and you started talking about the difficulties billionaires face and I pointed out that billionaires aren't poor and you came back saying "I carefully stated 'poor billionaires' " that doesn't suddenly mean you are now making sense." There are no poor billionaires...there are no chronic toxins. There is such a thing as chronic toxicity however you must understand the word toxin does not mean "anything that is toxic".

The bacterium vibro cholera produces a molecule that causes damage to the cell membrane of cells in your intestine rupturing and killing them in quick order. That is a toxin.

Fructose is not a toxin by the definition of the word toxin. Aspartame is not a toxin by the definition of the word toxin. Small molecules used as drugs produced in labs are not toxins by the definition of the word toxin.

People are just taking toxin to mean "anything that is toxic" and that is NOT the definition of the word at all, people are just misuing it.

So what do you mean when you say toxin? Do you mean "anything that can possibly cause us harm" because that seems to be the way you are using it. In that sense sure, any sugar is a toxin...oxygen is a toxin, anything we injest is a toxin because metabolic products of it cause us repairable damage that, although repairable, over long periods of time tear us down and increase our chance of cancer or chronic diseases.

Fructose, in the form of high fructose corn syrup, as a processed product no doubt has a lot to do with the ease at which American's become obese with their diets. That doesn't make fructose a "toxin". Words have meaning and we should use those words only when their meaning applies. Saying "chronic toxin" is like saying "poor billionaire" its antithetical to the very meaning of the word. Toxins, by definition of the word, have high toxicity at low concentrations in an acute fashion. If I am somehow mistaken please find a scientific publication or a scientific organization (such as the CDC) refering to a "chronic toxin" or something that is not a living organisms organic product as a toxin or something that causes damage only over the long term as a toxin and link to it. Do note you might find a phrase such as "chronic toxin exposure" but the chronic refers to the exposure not the toxin itself, so be careful.

Can look up cholera toxin as a cannonical example of a toxin, specifically a type of toxin known as an enterotoxin. BT, a pesticide, is also an enterotoxin but it only affects certain insects. Another property of toxins by the way, they tend to be organism specific. Cholera toxin wouldn't affect those insects.

I know I am repeating myself but I want to say this again for emphasis to anyone reading. Toxin DOES NOT MEAN "anything that is toxic". Toxic and toxin, despite how similar they look, are very different words.

It really seems like you are spiting hairs here. Perhaps you would prefer fructose is a dosage dependent hepatic chronic poison. That actually sounds worse in some ways. Not to create a debate but there does seem to be a multiple definitions of toxins in use. Your poor billionaire is just a oxymoron and really doesn't apply in this case or even make sense. The toxic effects of fructose are real as reveled my current science. Perhaps the verbal usages of the term is just more casual. What term do you suggest to refer to the toxic effects of fructose?

Viewing it that way wouldn't anything your liver has to process be considered a hepatic chronic poison? What makes fructose more of a hepatic chronic poison than say lactose or galactose or glycogen of any variety?

:"Not to create a debate but there does seem to be a multiple definitions of toxins in use. " Yes, their is the actual definition of the word and then there is the popularization of the word in common use in various blogs and websites on the internet that runs contrary to the actual definition. Toxin is a scientific term, it has a specific meaning...the public misusing the term doesn't somehow give it a new meaning it just means the public is misusing the term. They are treating it like toxin means something that is toxic and thats not what it means. I get that that is an easy mistake to make but its still a mistake.

Yes, poor billionaire is an oxymoron....so is chronic toxin. Chronic toxin makes as much sense as poor billionaire because billionaires are rich and toxins are acute poisons that are metabolic products of living organisms. There are no poor billionaies, there are no chronic toxins. That was my point.

"The toxic effects of fructose are real as reveled my current science."

What science? The links you provided at no point refered to fructose as a toxin nor as being toxic, you just kind of claimed that yourself. Can you perhaps link to something that says straight out that fructose is toxic?

If fructose was toxic then eating apples would be deadly. I don't really think that the "science is behind the controversy" on that one.

"What term do you suggest to refer to the toxic effects of fructose?" Well frankly I wouldn't because I don't think that fructose is toxic. But lets see I can pick something that is toxic like cyanide. Cyanide is an element, it can be found in plants (it is concentrated in natural almonds) but it isn't a metabolic product of plants so it isn't a toxin. I'd think in the case of cyanide that poison would be the appropriate term.

What you seem to be doing is conflating things that might damage our bodies long term and expecting them to be called something like a toxin or a poison. The thing is pretty much everything metabolically damages our bodies. Oxygen reeks absolute havoc on our bodies, but its not "toxic" nor is it a "poison". To be toxic or a poison means a specific interaction, a mechanism of action that leads to specific damage not just wear and tear.

Let me use a car as an analogy because I think people are more comfortable with the concepts behind a car engine than they are with the metabolic functions of our bodies.

A car runs on gasoline. That gasoline is taken into the cars engine where it is ignited and explodes. This explosion leaves residues on the parts of the engine, causes general wear, and eventually the engine will fail. Is gasoline a "poison" or a "toxin" to the car? No, of course not. Lets say you put sugar into the cars gastank and when that is taken into the engine it causes abrupt and sudden damage that requires immediate repair...now we are talking about a poison (or a toxin).

You might argue that fructose causes damage to a human body in the way that gasoline causes damage to a car, but that doesn't make it toxic man. I don't know where you are getting that from and I really highly doubt you can point to any science text or any scientifically published paper or any scientific organizations website that would say that fructose is "toxic" or a poison or a toxin. Frankly I think you are just saying that over time consumption of fructose (or really any carbohydrate) puts stress on our liver much the same way gasoline puts stress on a car engine but you are choosing words that are more dramatic despite the fact that by choosing those words you are now just incorrect because the words you are using don't have the meanings that you are attempting to use them for.