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Diabetes drug significantly cuts body weight in adults with obesity
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Obesity and T2D are protective mechanisms the body uses to protect itself from excessive consumption of sugar and carbs.
A medication is NOT the answer. Cutting out / down the poison is the answer.
Absolutely untrue. Obesity is not a protective mechanism. It is a result of excess calorie intake. Stop with your horrible advice all over these boards.
THANK YOU!4 -
Bumping because I heard about semaglutide elsewhere. I love the idea of an appetite suppressant without cardiovascular concerns, but the side effects sound dreadful, and weekly shots inconvenient.
https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014
For Immediate Release:
June 04, 2021
Today, the U.S. Food and Drug Administration approved Wegovy (semaglutide) injection (2.4 mg once weekly) for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), for use in addition to a reduced calorie diet and increased physical activity. This under-the-skin injection is the first approved drug for chronic weight management in adults with general obesity or overweight since 2014. The drug is indicated for chronic weight management in patients with a body mass index (BMI) of 27 kg/m2 or greater who have at least one weight-related ailment or in patients with a BMI of 30 kg/m2 or greater.
...The most common side effects of Wegovy include nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection) and gastroesophageal reflux disease (a type of digestive disorder).
The prescribing information for Wegovy contains a boxed warning to inform healthcare professionals and patients about the potential risk of thyroid C-cell tumors. Wegovy should not be used in patients with a personal or family history of medullary thyroid carcinoma or in patients with a rare condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Wegovy should not be used in patients with a history of severe allergic reactions to semaglutide or any of the other components of Wegovy. Patients should stop Wegovy immediately and seek medical help if a severe allergic reaction is suspected. Wegovy also contains warnings for inflammation of the pancreas (pancreatitis), gallbladder problems (including gallstones), low blood sugar, acute kidney injury, diabetic retinopathy (damage to the eye's retina), increased heart rate and suicidal behavior or thinking. Patients should discuss with their healthcare professional if they have symptoms of pancreatitis or gallstones. If Wegovy is used with insulin or a substance that causes insulin secretion, patients should speak to their health care provider about potentially lowering the dose of insulin or the insulin-inducing drug to reduce the risk of low blood sugar. Healthcare providers should monitor patients with kidney disease, diabetic retinopathy and depression or suicidal behaviors or thoughts.3 -
You would probably find contraindications for most meds.
As far as I know, it is not prescribed ( not on the PBS anyway) for weight loss here in Australia.
But used sometimes for type 2 diabetes not responding sufficiently to oral meds.
Sure, giving oneself an injection weekly is inconvenient- but by that stage, usually it is that or insulin, which of course is injected more often than weekly.2 -
Side effects do matter. Phen Phen worked. It also killed people who weren't aware of the side effects.
Weight loss is one of the one things that people are willing to chance with their lives for vanity reasons many times. Even people who are just a little overweight will chance a drug rather than do the real work to get it done.
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Following this thread. One aspect of it that I'd like to learn more about is the impact of this drug on appetite, and if that is a part of why it seems to work.
Thank you for posting!2 -
A thought about the side effects: if the test subjects were diabetics then retinopathy, kidney disease and low blood sugars are common issues in diabetes. Doubt if the drug worsens them. As for nausea and dizziness they are not uncommon symptoms of low blood sugar. Nausea is also caused by gastroparesis which can be caused by diabetic nerve damage so that the stomach empties slowly. Flatulence is also common when diabetics over consume carbohydrates. I had diagnosed diabetes for over 21 years before receiving a kidney/pancreas transplant. I still suffer from gastroparesis, lost one eye to retinopathy and have experienced all the issues that I mentioned. Please keep in mind that if any person in the test groups experiences a medical issue, the issue is recorded as a side effect whether it is related to the drug or not. Personally, I would have taken this medication if it was available to me.4
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OK, now been on this for just over 9 weeks. Was prescribed for pre-diabetes. Almost 54 and post menopausal, which was when my struggle with losing weight started in all earnest.
Sugar is down to a normal level, I lost 17lbs so far, eating around 1200-1500 calories a day. Moderate workouts (kettlebells ) for 30 mins three times a week and walking 10 000 steps most days. (Workouts halted and walked a lot less for three weeks due to covid)
For all the clever people who would insist that I would have gotten the same results without the drug, please go lift some weights or read a book - you are wrong. I could never eat so litte and stick to this amount of food AND be active before.
My blood pressure is down from hovering around high to normal.
Minimal side effects so far other than the loss of appetite. Some excessive burping when I ate a bit too much, constipation a couple of times but more fibre or a dose of Metamucil took care of that. A bit of nausea right in the beginning, but then I realized I was not eating enough. No real cravings and ate more or less anything I want, just in small amounts.
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1. What are the side effects of this drugs
2. What are the side of effects of exercising and not overeating
Although #2 is hard work, I would much prefer that to what the side effects of what #1 would be
Side effects for me are minimal - some constipation (my own fault as I had too little fibre) and a loss of appetite - whick is the whole idea. More side effects are lower BP, regulated sugar in the normal levels and weight loss.
The side effects of exercising and not overeating for me was getting fitter, a slight lowering or BP and nothing more.... Weight loss would be losing and gaining the same two pounds over and over and over. Even though I was eating "healthy" food in limited quantities, my blood sugar was fluctuating a lot more than what is considered healthy.
When I was in my 20's, 30's and 40's I could work out every day and eat lower calories, lose weight and keep it off. Unfortunately I was just as smug and uninformed as you are, and due to life and injuries getting in the way, I gained a bunch back. Imagine my surprise when the "exercise and not overeating" did not work anymore...
And if you think for one second that using this meds and working out and eating lower calories is not hard work, I suggest you talk to a few more people and maybe try and keep an open mind and learn something in the process.7 -
Hi all,
I have been taking Wegovy for about 3 months now, I have not experienced any positive side effects. Instead, I often find myself nauseous, experiencing regular heartburn, and feeling more tired than normal. My current dose is 1.0 MG' and I have spoken to my doctor yesterday to express my concerns. She has now prescribed Phentermine to kick start my weight loss journey. I am interested to hear how others have responded to this new medication.0 -
Below is the mechanismSemaglutide acts like human glucagon-like peptide-1 (GLP-1) so that it increases insulin secretion, thereby increasing sugar metabolism.
This is an important comment, because insulin resistance isn't cured by adding more insulin.
I'm using a freestyle libre lately, to measure my blood sugars, and it has led me to get lower and lower carb in my diet, because that way my blood sugars don't go crazy. For instance, 1/2 tsp sugar will send me upwards of 11, 12... bad stuff.
Been watching a few youtubes and I think the consensus for type 2 diabetes is to lose weight to reduce resistance - but also to reduce carbs. That way I won't make as much insulin, and can resensitise to it.
Either way I have to say it's making me feel a lot better, and I don't get anything like as hungry.0 -
Obesity and T2D are protective mechanisms the body uses to protect itself from excessive consumption of sugar and carbs.
A medication is NOT the answer. Cutting out / down the poison is the answer.
Sugar and carbs are not a poison. Excessive consumption in any possible macronutrient mix can result in obesity and T2D.
I can't find the original post by Tsazani. Which is a shame, because sucrose and hfcs, in the quantities the western world consumes it in, IS toxic. It is very toxic.
Fructose is a 5 sided molecule, that your body cannot metabolise properly and that your brain can't see. It has to be dealt with in the liver, and creates a fatty droplet and triglycerides. Glucose is fine, but sucrose is 1 fructose and 1 glucose molecule. So that's fatty droplets, triglycerides, LDL cholesterol all being made right there, to deal with this stuff. You get to use some of it, but mostly it gets stored.
Overconsumption of fructose can lead to cirrhosis of the liver, high cholesterol, definitely obesity. This is because when your body sees it, it tries to store it.
As to glucose, being what all carbohydrates end up as, the safe six sided molecule, this will intially have some storage in the liver as glycogen, which is fine. But what happens to the glucose that goes into the blood?
Answer? Insulin.
You eat the carbs, the insulin shows up and hurtles round, bringing the glucose into cells, and storing it as fat. You're in store mode. And you'll mop it all up and tidy it away in a couple of hours and then find yourself hungry again. This is how high carb eaters can eat a pile of food and still be starving. Their bodies are storing the carbs as fat, so those carbs aren't available to be used.
So if you are eating carbs, and they're going into your blood, and your body is storing them, that is the antithesis of what you are attempting to achieve.
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But what happens to the glucose that goes into the blood?
Answer? Insulin.
Yes - extremely simplified summary of the normal physiological system.
One makes insulin to regulate blood sugar levels
This is not a bad thing - or a fat causing thing. It is a healthy body working normally thing.
Too many calories are the source of fat storing - ie gaining weight
And your body is perfectly capable of metabolising fructose - people have eaten fruit perfectly well since time immemorial.
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So if you are eating carbs, and they're going into your blood, and your body is storing them, that is the antithesis of what you are attempting to achieve.
I've been eating a very high, ~52% carb diet for the most part of the last two years (I'm following the Med diet since it is very easy to do so here in Greece). When I started, I was pre-diabetic and suffering from NAFLD, among other things.
According to your "findings", with a mean daily total consumption of >200gr carbs, including more than 30grams of pure fructose..I would have been dead by now. Fortunately, I'm 205 pounds lighter, my liver is clear and my blood sugar is exceptional.
My friend, please stop reading bad science (or to be more precise, mis-understanding science in general). Whether eating less carbs works well for you personally is completely irrelevant to the point you were trying to make. Youtube is definitely not helping you on this.
I'll reiterate. Excessive consumption in any possible macronutrient mix can result in obesity and T2D.
Really hope this helps.
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TBH I'd never heard of this approach before and know nothing about it. But I was talking with my dd last night and they'd prescribed the injection for her. Luckily her insurance wouldn't pay for it so she canceled her appointment to go forward with it. She said it'd cost her about 1K a month.
I am so skeptical of using drugs to make this happen. It's scary to think about as far as long-term consequences. I remember using Dexatrim way back in my late teens. I became so fidgety, irritable and nervous I had to quit. I'm not anti-drug per se but feel that everything causes a reaction of some kind.
Simply put, there is no easy way to achieve desired weight loss. But it can be done.1 -
I personally in the past was prescribed victoza but experienced side effects. He switched me to Trulicity and I am doing much better. My new endocrinologist is supportive of me taking it. As he explained it is not an insulin. It is an enhancer for insulin. I feel it helps curb my appetite and I am not having food cravings or feeling the need to eat between meals.
I think it is always best to talk to your dr and figure out what is best and may work for you because we are all different. What works for one person may not work for another. I wish you well.3 -
Is it up to MFP standards to discuss Semaglutides? Are there some MFP rules regarding this? I believe things are censored according to MFP standards, but I've not read any published standards for MFP posting. Do they exist?0
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chris_in_cal wrote: »Is it up to MFP standards to discuss Semaglutides? Are there some MFP rules regarding this? I believe things are censored according to MFP standards, but I've not read any published standards for MFP posting. Do they exist?
What? What do you mean?
If it's legal, we can talk about it. Here are the general Community Guidelines:
https://www.myfitnesspal.com/community-guidelines
This is posted in the Debate Club section, too. There will be lots of opinions here. You can read the Debate Club "rules" here:
https://community.myfitnesspal.com/en/discussion/10331444/welcome-to-the-debate-health-and-fitness-category-please-read
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It seems a thread was removed from Debate Club today.
I'm new in this "Debate Club" category and have never observed a thread being removed. I was surprised (though I could just be mistaken on this)0
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