Leaky gut

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  • nxd10
    nxd10 Posts: 4,570 Member
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    If they saw chronic inflammation on the scope wouldn't that be IBD?

    No. And my chronically ill son, who has the worst inflammation and has tested positive for food sensitivities, has none of them and no symptoms at all that his intestines have a problem. It was only because he was vomiting all the time (before his migraines started) that they scoped him. The inflammation causes all the problems usually called 'leaky gut'. Like I said - stupid name, and I'm sure most people don't understand it - but real phenomenon.
  • MarziPanda95
    MarziPanda95 Posts: 1,326 Member
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    nxd10 wrote: »
    If they saw chronic inflammation on the scope wouldn't that be IBD?

    No. And my chronically ill son, who has the worst inflammation and has tested positive for food sensitivities, has none of them and no symptoms at all that his intestines have a problem. It was only because he was vomiting all the time (before his migraines started) that they scoped him. The inflammation causes all the problems usually called 'leaky gut'. Like I said - stupid name, and I'm sure most people don't understand it - but real phenomenon.

    That's all well and good but I know several people who use 'leaky gut' and mean 'I believe for some reason that my bowel is literally leaking into my bloodstream and causing my autoimmune problems'... which is completely false, of course. Fair enough to those with actual problems but the term has been hijacked (and yes, has a name that is totally misleading).
  • ydyms
    ydyms Posts: 266 Member
    edited December 2015
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    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)
  • BinaryPulsar
    BinaryPulsar Posts: 8,927 Member
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    ydyms wrote: »
    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)

    I have to eat a low histamine diet also.
  • ydyms
    ydyms Posts: 266 Member
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    ydyms wrote: »
    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)

    I have to eat a low histamine diet also.

    Could you please give me ideas what to eat? I'm eating the same few foods every day :(
  • neohdiver
    neohdiver Posts: 738 Member
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    neohdiver wrote: »

    Do you have any pubmed articles to link?

    Here's a sampling - since you didn't specify a particular area of interest:

    Vancomycin - two case reports: http://www.ncbi.nlm.nih.gov/pubmed/19840535; http://www.ncbi.nlm.nih.gov/pubmed/6853034

    . . .

    IBS and gut permeability: http://www.ncbi.nlm.nih.gov/pubmed/25734736

    . . .

    As you can see from the sampling, it is a fairly hot topic these days.

    Always read your sources.

    First two articles focus on renal failure and insufficiency for proper clearance of the drug.

    The IBD reference suggests a mechanism for increases "ovalbumin transport, probably by augmented transcytosis" and not an increase in general permeability...

    The first two articles focus on a combination of renal and GI failures - enteritis, in the first instance and unspecified intestinal disease in the second. Oral vancomycin does not normally pass through the gut epithelial layer of molecular size of vancomycin. It normally treats the condition within the gut and is excreted as part of the stool. The only time oral vancomycin would require renal clearance is if the gut is permeable enough to permit oral vancomycin to pass through its walls and enter the bloodstream. If it enters the bloodstream (because of, in the two articles, enteritis or intestinal disease make the gut more permeable to vancomycin than normal, then impaired renal function is a significant concern because of the inability to clear vancomycin that should not have found itself into the bloodstream in the first place. In other words, the concern about renal insufficiency is secondary to a gut that permits oral vancomycin to enter the bloodstream (something that does not happen in a normal gut). As noted in my initial post, this is an area in which I have considerable personal experience that required substantial research, consultations with experts in the field and, ultimately, my daughter's involvement in a research study in which the question of whether her GI disease made her gut permeable to vancomycin determined whether she would be permitted to remain in the study - precisely because of the significantly increased risks associated with having measurable levels of vancomycin in her bloodstream (including the potential that her kidneys would be unable to properly clear it).

    As to the IBD article, I did not claim it theorized an "increase in general permeability." I provided a series of links to articles that discuss a variety of aspects of gut permeability, ultimately in response to the poster who initially claimed, "If your gut leaked you'd be in the hospital with blood poisoning!" As a blanket statement, that claim is medical nonsense. My original response discussed some of the many variations of gut permeability established or being researched. The links I provided continue that line of discussion. I made no blanket claims about general permeability - so pointing out that an article doesn't discuss general permeability doesn't counter anything I claimed.
  • BinaryPulsar
    BinaryPulsar Posts: 8,927 Member
    edited December 2015
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    ydyms wrote: »
    ydyms wrote: »
    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)

    I have to eat a low histamine diet also.

    Could you please give me ideas what to eat? I'm eating the same few foods every day :(

    I know! Me too! It's so ridiculous, isn't it? I am following The Low Histamine Chef. And there are groups on Facebook where you can talk to lots of people for help navigating through this. It's very individual. Depends per person. I am also eating the same foods every day. But, I can share with you what I eat. My issues are not GI. I have a nerve injury in my face with a mast cell malfunction and vasomotor malfunction. Histamine increases pain in my face and eyes and can cause flushing. I was injured by a med, so it's pretty severe. My Rheumatologist thinks I will recover, but maybe could take a year. I am able to eat nuts and seeds and chik peas. I just opened my food diary (for now), and posted what I eat on my profile (for now). I will share it here with you also.

    *1/2 cup blueberries, 1/2 cup blackberries, ground flax (4 tbsp) & chia seed (2 tbsp), silk unsweetened coconut milk

    *3/4 cup butternut squash & 1/2 cup sweet potato

    *nuts (some each meal): 20 almonds, 20 hazlenuts, 8 brazil, handful pecans, sunflower seeds

    *apple/pear

    *1 & 3/4 cups cooked chikpeas/salt (eden organic)
    *1/4 cup dry quinoa (cooked)
    *cucumber
    *bell pepper
    *carrots
    *broccoli
    *leafy greens
    *occasionally Larry & Luna's coconut bliss bar (coconut frozen desert bar)

    I also have a helpful app on my android phone called Baliza food intolerances.
  • BinaryPulsar
    BinaryPulsar Posts: 8,927 Member
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    Also you can take Quercetin and Vitamin C (calcium ascorbate) three times a day with meals. They are natural antihistamines.
  • Jillasmar
    Jillasmar Posts: 85 Member
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    I went to the doctor about something similar. I had to stop eating things containing sucrose. Like dried fruits, pears, apples, gummy foods. They all bloated me and made me very gassy and constipated. I feel a lot better now although I am not completely bloat free. I also have celiacs disease so I do not eat gluten
  • nxd10
    nxd10 Posts: 4,570 Member
    edited December 2015
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    nxd10 wrote: »
    If they saw chronic inflammation on the scope wouldn't that be IBD?

    No. And my chronically ill son, who has the worst inflammation and has tested positive for food sensitivities, has none of them and no symptoms at all that his intestines have a problem. It was only because he was vomiting all the time (before his migraines started) that they scoped him. The inflammation causes all the problems usually called 'leaky gut'. Like I said - stupid name, and I'm sure most people don't understand it - but real phenomenon.

    That's all well and good but I know several people who use 'leaky gut' and mean 'I believe for some reason that my bowel is literally leaking into my bloodstream and causing my autoimmune problems'... which is completely false, of course. Fair enough to those with actual problems but the term has been hijacked (and yes, has a name that is totally misleading).

    Yes people think that. It's the plastic bag theory of the human body. Things go in one end, out the other, and there's a big bag inside you that holds it while there. Sometimes there are little holes in it.

    Not my son's problem. The name is just dumb. But he's just really sick.
  • nxd10
    nxd10 Posts: 4,570 Member
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    ydyms wrote: »
    ydyms wrote: »
    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)

    I have to eat a low histamine diet also.

    Could you please give me ideas what to eat? I'm eating the same few foods every day :(

    My son - and the whole family - is on a low tyramine/histamine diet because of my son's severe migraines. Also no gluten/egg/cow dairy because of tested sensitivities. Good thing my husband and I love to cook.

    It's not hard once you start. Don't think about what you can't eat, think about what you can. I'm sure you have a list - don't think about what you can't eat. Think about what you can and just put those ingredients into epicurioous.com.

    THE SINGLE HARDEST THING IS THAT ALL FOOD HAS TO BE SUPER FRESH. So you cook a chicken today, it's fine. You put it in the refrigerator. Tomorrow night those leftovers are high in tyramine and histamine because of breakdown products from the amino acids.

    Buy very fresh or fresh frozen meat - we buy frozen chicken breasts/thighs and fish from Trader Joes in big bags (pretty cheap) and fresh meat from a butcher who cuts the meat that morning. If it's been frozen and thawed and is in a case at the grocery store, it's high in tyramine.

    Freeze all leftovers. So cook, cook, and freeze. When you want to eat them, thaw in microwave.

    Don't eat coldcuts or things from a deli case. People blame nitrates, etc. for getting migraines from ham or sliced roast beef. It's probably just the tyramine. It is cooked and sits in the deli counter. You buy it and it sits your fridge. It's just old (not unsafe, just high in tyramine/histamine). Don't eat it. We make a roast pork, chicken, or beef every Sunday, slice and freeze it for sandwiches.

    National Headache Foundation has good guidance on it (http://www.headaches.org/2012/01/13/headache-sufferers-diet/).

    After the family went on it for my son's migraines, my husband's heart stopped skipping and his blood pressure dropped. The thing tyramine does in normal people's bodies who can digest it is regulate blood pressure and heart rate.
  • BinaryPulsar
    BinaryPulsar Posts: 8,927 Member
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    nxd10 wrote: »
    ydyms wrote: »
    ydyms wrote: »
    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)

    I have to eat a low histamine diet also.

    Could you please give me ideas what to eat? I'm eating the same few foods every day :(

    My son - and the whole family - is on a low tyramine/histamine diet because of my son's severe migraines. Also no gluten/egg/cow dairy because of tested sensitivities. Good thing my husband and I love to cook.

    It's not hard once you start. Don't think about what you can't eat, think about what you can. I'm sure you have a list - don't think about what you can't eat. Think about what you can and just put those ingredients into epicurioous.com.

    THE SINGLE HARDEST THING IS THAT ALL FOOD HAS TO BE SUPER FRESH. So you cook a chicken today, it's fine. You put it in the refrigerator. Tomorrow night those leftovers are high in tyramine and histamine because of breakdown products from the amino acids.

    Buy very fresh or fresh frozen meat - we buy frozen chicken breasts/thighs and fish from Trader Joes in big bags (pretty cheap) and fresh meat from a butcher who cuts the meat that morning. If it's been frozen and thawed and is in a case at the grocery store, it's high in tyramine.

    Freeze all leftovers. So cook, cook, and freeze. When you want to eat them, thaw in microwave.

    Don't eat coldcuts or things from a deli case. People blame nitrates, etc. for getting migraines from ham or sliced roast beef. It's probably just the tyramine. It is cooked and sits in the deli counter. You buy it and it sits your fridge. It's just old (not unsafe, just high in tyramine/histamine). Don't eat it. We make a roast pork, chicken, or beef every Sunday, slice and freeze it for sandwiches.

    National Headache Foundation has good guidance on it (http://www.headaches.org/2012/01/13/headache-sufferers-diet/).

    After the family went on it for my son's migraines, my husband's heart stopped skipping and his blood pressure dropped. The thing tyramine does in normal people's bodies who can digest it is regulate blood pressure and heart rate.

    Thanks for the info. I ended up just going vegan because it was so difficult reacting to animal products. Mine was induced by a medical injury from being wrongly prescribed a harmful med. I get trigeminal nerve pain and migraines also. It's very difficult to explain to people and the pain is intense, but not actually visible on the outside unless I flush, but I only flush when the pain gets very very severe. But, people think it's just flushing. It's not. It's severely painful. I flush (color change in skin) from neurological pain. It's a pretty terrifying experience. And impacts my vision as well. Everytime I lie down the pain increases. I can't even take advil or Tylenol. It increases the pain because the med caused hypersensitivity. I can't eat oils either.
  • nxd10
    nxd10 Posts: 4,570 Member
    edited December 2015
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    nxd10 wrote: »
    ydyms wrote: »
    ydyms wrote: »
    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)

    I have to eat a low histamine diet also.

    Could you please give me ideas what to eat? I'm eating the same few foods every day :(

    My son - and the whole family - is on a low tyramine/histamine diet because of my son's severe migraines. Also no gluten/egg/cow dairy because of tested sensitivities. Good thing my husband and I love to cook.

    It's not hard once you start. Don't think about what you can't eat, think about what you can. I'm sure you have a list - don't think about what you can't eat. Think about what you can and just put those ingredients into epicurioous.com.

    THE SINGLE HARDEST THING IS THAT ALL FOOD HAS TO BE SUPER FRESH. So you cook a chicken today, it's fine. You put it in the refrigerator. Tomorrow night those leftovers are high in tyramine and histamine because of breakdown products from the amino acids.

    Buy very fresh or fresh frozen meat - we buy frozen chicken breasts/thighs and fish from Trader Joes in big bags (pretty cheap) and fresh meat from a butcher who cuts the meat that morning. If it's been frozen and thawed and is in a case at the grocery store, it's high in tyramine.

    Freeze all leftovers. So cook, cook, and freeze. When you want to eat them, thaw in microwave.

    Don't eat coldcuts or things from a deli case. People blame nitrates, etc. for getting migraines from ham or sliced roast beef. It's probably just the tyramine. It is cooked and sits in the deli counter. You buy it and it sits your fridge. It's just old (not unsafe, just high in tyramine/histamine). Don't eat it. We make a roast pork, chicken, or beef every Sunday, slice and freeze it for sandwiches.

    National Headache Foundation has good guidance on it (http://www.headaches.org/2012/01/13/headache-sufferers-diet/).

    After the family went on it for my son's migraines, my husband's heart stopped skipping and his blood pressure dropped. The thing tyramine does in normal people's bodies who can digest it is regulate blood pressure and heart rate.

    Thanks for the info. I ended up just going vegan because it was so difficult reacting to animal products. Mine was induced by a medical injury from being wrongly prescribed a harmful med. I get trigeminal nerve pain and migraines also. It's very difficult to explain to people and the pain is intense, but not actually visible on the outside unless I flush, but I only flush when the pain gets very very severe. But, people think it's just flushing. It's not. It's severely painful. I flush (color change in skin) from neurological pain. It's a pretty terrifying experience. And impacts my vision as well. Everytime I lie down the pain increases. I can't even take advil or Tylenol. It increases the pain because the med caused hypersensitivity. I can't eat oils either.

    I understand. My son spent yesterday whimpering in the dark from high sensitivies and migraines. Pain meds don't work for him so he doesn't even bother taking them. He's usually awesome at dealing with the pain and sensitivities - he has had excellent training from a clinical pain specialist (which I highly highly recommend if you have not done so already). But he came off a 3 week stomach virus and hadn't eaten. The inability to eat, dehydration, and lack of exercise triggered a nightmarish one.

    The easiest way for me to describe his diet is gluten-free vegan with meat. BTW, Indian cuisines are the easiest to eat unmodified, as well as Northern European if you avoid the wheat. Good luck. Fortunately, the internet provides a lot of resources. There are many more people out there suffering from chronic pain than anyone can imagine.
  • BinaryPulsar
    BinaryPulsar Posts: 8,927 Member
    edited December 2015
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    nxd10 wrote: »
    nxd10 wrote: »
    ydyms wrote: »
    ydyms wrote: »
    I have a leaky gut, and was diagnosed with a histamine intolerance as the cause of it. Once I started to eat super low histamine, I started to heal thankfully! (I'm the op here.)

    I have to eat a low histamine diet also.

    Could you please give me ideas what to eat? I'm eating the same few foods every day :(

    My son - and the whole family - is on a low tyramine/histamine diet because of my son's severe migraines. Also no gluten/egg/cow dairy because of tested sensitivities. Good thing my husband and I love to cook.

    It's not hard once you start. Don't think about what you can't eat, think about what you can. I'm sure you have a list - don't think about what you can't eat. Think about what you can and just put those ingredients into epicurioous.com.

    THE SINGLE HARDEST THING IS THAT ALL FOOD HAS TO BE SUPER FRESH. So you cook a chicken today, it's fine. You put it in the refrigerator. Tomorrow night those leftovers are high in tyramine and histamine because of breakdown products from the amino acids.

    Buy very fresh or fresh frozen meat - we buy frozen chicken breasts/thighs and fish from Trader Joes in big bags (pretty cheap) and fresh meat from a butcher who cuts the meat that morning. If it's been frozen and thawed and is in a case at the grocery store, it's high in tyramine.

    Freeze all leftovers. So cook, cook, and freeze. When you want to eat them, thaw in microwave.

    Don't eat coldcuts or things from a deli case. People blame nitrates, etc. for getting migraines from ham or sliced roast beef. It's probably just the tyramine. It is cooked and sits in the deli counter. You buy it and it sits your fridge. It's just old (not unsafe, just high in tyramine/histamine). Don't eat it. We make a roast pork, chicken, or beef every Sunday, slice and freeze it for sandwiches.

    National Headache Foundation has good guidance on it (http://www.headaches.org/2012/01/13/headache-sufferers-diet/).

    After the family went on it for my son's migraines, my husband's heart stopped skipping and his blood pressure dropped. The thing tyramine does in normal people's bodies who can digest it is regulate blood pressure and heart rate.

    Thanks for the info. I ended up just going vegan because it was so difficult reacting to animal products. Mine was induced by a medical injury from being wrongly prescribed a harmful med. I get trigeminal nerve pain and migraines also. It's very difficult to explain to people and the pain is intense, but not actually visible on the outside unless I flush, but I only flush when the pain gets very very severe. But, people think it's just flushing. It's not. It's severely painful. I flush (color change in skin) from neurological pain. It's a pretty terrifying experience. And impacts my vision as well. Everytime I lie down the pain increases. I can't even take advil or Tylenol. It increases the pain because the med caused hypersensitivity. I can't eat oils either.

    I understand. My son spent yesterday whimpering in the dark from high sensitivies and migraines. Pain meds don't work for him so he doesn't even bother taking them. He's usually awesome at dealing with the pain and sensitivities - he has had excellent training from a clinical pain specialist (which I highly highly recommend if you have not done so already). But he came off a 3 week stomach virus and hadn't eaten. The inability to eat, dehydration, and lack of exercise triggered a nightmarish one.

    The easiest way for me to describe his diet is gluten-free vegan with meat. BTW, Indian cuisines are the easiest to eat unmodified, as well as Northern European if you avoid the wheat. Good luck. Fortunately, the internet provides a lot of resources. There are many more people out there suffering from chronic pain than anyone can imagine.

    Thank you! Oh, I am so sorry your son has to go through this. He is so strong. I hope he will improve. You are a strong and good parent to do so much to help ease some of this for him. Merry Christmas! ♥

    Edit to add: Yeah, my diet is vegan and gluten free and low histamine. I added one egg yolk today, so hopefully that will work out. At some point I might try fresh chicken again since my diet is so limited.
  • ydyms
    ydyms Posts: 266 Member
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    I have a question for those of you unfortunate ones knowledgeable about the leaky gut: I've read conflicting reports about exercise, specifically cardio. Is cardio exercise bad for a leaky gut? I definitely become super bloated after a run and I was wondering if there's a connection...
  • BinaryPulsar
    BinaryPulsar Posts: 8,927 Member
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    I don't know about leaky gut. But, if you have histamine intolerance exercise does increase histamine. It's healthy for you. Just need to be cautious and find the right balance.
  • nxd10
    nxd10 Posts: 4,570 Member
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    My son has clear medical documentation of what is called 'leaky gut' (inability to digest tyramine/histamine, chronic serious inflammation, gluten/dairy/egg sensitivity, a whole raft of dietary deficiencies despite supplements) that causes chronic severe migraine and pain. Exercise was recommended by my son's neurologist, functional medicine specialist, and pain specialist. And it REALLY helps. One very important factor is actually not being sedentary. If he sits too long it triggers problems - he actually has a watch that reminds him to get up every hour and it makes a big difference.

    At least an hour 3 x a week minimum was recommended. You have to find something that works for you. What I know my sister had problems with was when she got high lactic acid buildup from the way she was exercising. My son's PT told him to keep a good steady sustainable pace that kept his heart up but didn't give him a muscle 'burn'. That would be consistent with my sister's experience.
  • nxd10
    nxd10 Posts: 4,570 Member
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    But bloat after running can just be because it gets your gut moving. You may simply need more fiber and water. Metamucil is a simple easy help for bloat.
  • BinaryPulsar
    BinaryPulsar Posts: 8,927 Member
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    Thanks for the info about exercise and neuropathic pain. I was incredibly active before my medical injury (professional dancer). And have become sedentary. I am adding exercise back in.