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Why do people deny CICO ?

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  • stanmann571
    stanmann571 Posts: 5,727 Member
    I agree with everything @AnnPT77 said and will add my own slight off average example. I have PCOS, borderline low thyroid (not low enough to warrant medications), and an injury that rendered me unable to sit for long periods of time so most my sedentary time is spent lying down. My "sedentary" is essentially lower than calculated sedentary, and I burn fewer calories through activity than average. I could say that I have a "slower metabolism" by about 150-180 calories. This is why I need to be more active than the average person to achieve the same kind of loss. Understanding how CICO works helped me put together a plan that works for my CICO.

    While there exist cases where people are burning fewer calories (I'm a prime example), in most cases this isn't what's happening. And the overwhelmingly vast majority of these cases, being an outlier doesn't make it impossible to lose weight while getting adequate nutrition. You'll be extremely hard pressed to find someone who truly would gain on 1200 calories unless extremely small in stature (in which case their nutritional needs are different and can be fulfilled within a smaller calorie limit).

    Psychological sustainability is a whole other can of worms and I believe I'll break a woo record if it ever gets discussed because I believe people who find a normal weight unsustainable are better off if they stick to the lowest sustainable weight for them even if it falls in the overweight (or even obese) range, but keep working on acquiring skills and strategies that can potentially lower the threshold for what is sustainable.

    I suspect you're mistaken on this point, as I've found a great deal of acceptance as a relatively fit and still obese(when I hit the bottom of my maintenance range I'll be just barely overweight) person. I still have to work to stay fit and healthy, but I've chosen to accept a higher maintenance range. I may someday(when I become much less active) get into the high "normal" range. But for now, I like to eat, and I like to train, and I know how to cut if and when I choose to, and I've got the skills to do so, it's just not that much of a priority.
  • PAV8888
    PAV8888 Posts: 14,336 Member
    edited April 2018
    But Harris-Benedict (and revisions including the ones used by mfp and Fitbit) are often found to not accurately enough predict individuals who are observed directly. Or at least not accurately enough so that researchers still try to tinker with the predictive formulas and delineate populations where "their" equation would work better, or be more precise

    Now before anyone else misinterprets, this has nothing to do with CICO or an inability to succeed in losing weight based on starting from a starting point that could be derived from even worse than the available equations (or even be arbitrarily chosen) and correcting based on individual results over time.

    I am just trying to understand (with my limited understanding of statistics) why interperson REE variability would not exceed 5%.

    MFP uses Mifflin which I understand is a revision of Harris-Benedict.

    https://www.ncbi.nlm.nih.gov/m/pubmed/21458373/
    The Mifflin under-predicted RMR in both sexes, normal weight individuals, 40-60 year olds, and non-Hispanic White participants.

    However, clinical judgment and caution should be used when applying these prediction equations to special populations **or small groups**

    N=1 is a very small group. Individual forum threads deal with n=1s. The totality of forum threads behaves closer to the population.

    ... at an individual level, both equations have wide limits of agreement and clinically
    important differences in REE would be obtained.

    Our results are in agreement with other studies in this fi eld.[1,8,10] Boullata et al, in 2007 compared predictive equations of REE and indirect calorimetry in hospitalized patients and
    found that even the most accurate equation (the Harris-Benedict 1.1) was inaccurate in 39% of patients and had an unacceptably high error

    https://www.google.ca/url?sa=t&source=web&rct=j&url=https://pdfs.semanticscholar.org/caf8/dca3049a274c3fa76b9a322a0b8e190b8a1b.pdf&ved=2ahUKEwiExKXfnqHaAhXLasAKHacqDwQQFjAFegQIABAB&usg=AOvVaw1GVOvFwAI97OZJ-Hw3JFkn

    Of course in hospitalized patients something else is happening too and this would have implications as to whether the patient is hyper or hypo metabolic.

    The point being though that without a complete history we don't know whether the somebody posting is hyper or hypo metabolic and people are not well known for disclosing every pertinent issue they have up front.

    And while millions and millions of people are absolutely normal [just like the British actress in the clip we often link to, and as I found out for myself once I started using MFP and Fitbit and doing a dexa scan or two, myself] given how few people make it to MFP in the first place, and how few of them then post, I don't see why it is impossible to run into a-typical individuals more often than the full population statistics would indicate.

    And yes, everything Ann said above is true, with the vast majority of perceived situations that CICO is not working stemming from an inability to correctly evaluate a combination of inputs and results.

    So just to be clear. I believe that CICO applies 100% of the time but can be hard to pin down the exact numbers when it comes to a particular individual, and even at different points time, for a particular individual.

    And that a (very few) times [but more often seen on MFP than elsewhere] the the answer may not be "eat less to lose", because eat less to lose sometimes is addressing the wrong part of CICO for the particular person and is doing so with the wrong tool.

    You know, the break the wall by banging it with your head analogy.
  • PAV8888
    PAV8888 Posts: 14,336 Member
    edited April 2018
    See and this is where I will perhaps find the Crux of our slight disagreement, capturing adaptation capturing temporary compromise due to illness or whatever else is going on in a person's life is part (sometimes) of giving the correct answer to someone who is not able to lose weight even though they eat very little, specifically because both sides of the equation play off one another.

    Considering some degree of REE variance from the expected mean, considering an even bigger variance from an expected tdee, neither of these negates the fact that with sufficient effort and attention weight loss can be achieved and maintained.

    Now it may change slightly in terms of whether you try to feather a situation or sledgehammer it. It may change the way you go about doing it. Maybe even radically. But it doesn't change the fact that what you're trying to achieve is manipulate the effective CI versus the effective CO to tilt the way you want them to arrive at the results you want.

    The weird part is because I I agree wholeheartedly with the main points of your last paragraph, including the bigotry of low expectations and understanding your debits and credits, is why I disagree with your excluding things such as age and hormones by considering them inconsequential.

    I guess I do the same to a degree by not considering TEF or the exact calories of nuts or extra non digestion generated by OMAD to be part of the consequential debits and credits.

    Or on second thought, I consider that whatever those effects may be, they are less important than ease of adherence.
  • solieco1
    solieco1 Posts: 1,559 Member
    edited April 2018

    @AnnPT77

    "Rare things happen rarely. Common things happen commonly."

    This. So succinct, so perfect. Just this. Well, and basic physics.




  • ugofatcat
    ugofatcat Posts: 385 Member
    ericjaton5 wrote: »
    First off, I'd like to say how wonderful it is to have a community that can discuss a topic such as this at a high level and use evidenced-based argument.

    I do have issues with CICO and how it is applied to people's weight loss regimens. It also ignores metabolism physiology and is a simplified "tag line" that can be easily explained to the masses but when applied in this simplified format is, in my opinion, not very helpful.

    I don't think anyone is arguing about the 2nd law of thermodynamics here. Energy cannot be created or destroyed. Calories in equals calories out. I 100% agree with this statement.

    The issue I have is where the calories in and calories out actually come from. Let's do some simple derivation to better understand the physiology of what energy compartments the body utilizes.

    Calories In = Calories Out
    Makes sense so far right?
    Energy Reserves + Dietary Intake = Calories Out
    Here we breakdown calories in - they can come from the food they eat, or energy the body has already stored
    Energy Reserves + Dietary Intake = Metabolism (BMR) + Excretion + Physical Activity
    Here we breakdown calories out - We burn energy via cellular metabolism (BMR, which likes others have said does alter according to caloric intake), excretion (wasted/excreted/peed/pooped nutrients not utilized by the body), and physical activity
    (Glycogen + Adipose + Protein) + (Carbs + Fat + Protein) = (Thermogenesis + Cellular Demands) + Excretion + Physical Activity
    So here I breakdown energy reserves by categories and try to define storage compartments of energy that the body can actively target

    Almost all people losing weight want to optimize adipose tissue targetting for energy.

    My issue with CICO is that it COMPLETELY DISREGARDS how to optimize adipose breakdown (lipolysis) or the physiologic regulatory mechanisms surrounding how to crack this energy compartment within the body.

    Yes, simple caloric restriction will make you lose weight over the long term. But chronic caloric restriction, as we already know, also decreases basal metabolic rate THAT DOES NOT RECOVER. There was a study looking at long-term caloric restriction and daily exercise, and at 7 YEAR follow up, these human subjects still had decreased BMR (I don't have a link right now but if people want to pick it apart I'll go find it). Other issues are symptomatic, people feel cold, are tired, and hungry all the time. In addition, chronic caloric restriction decreases sex hormones and decreases BDNF, and GH. These are important hormones required to maintain lean body mass during weight loss.

    Another issue is that chronic caloric restriction is extremely difficult to maintain. There was a large clinical trial (n=1000 or something big) I think in the 90s that used CR and exercise to have people lose weight, and at 6 month follow up at a 95% failure rate, and after a year the majority of subjects gained most of the weight back.

    CICO does not take into consideration nutrient timing, the influence of sleep, nutrition, the hormonal theory of obesity, and in vivo energy balance physiology. This is why I don't recommend the CICO weight loss concept to other people.

    I am on my phone so formatting may be screwed up.

    1st, CO takes into account hormones, exercise, lack of sleep, cortisol, thyroid, thermoelectric of food etc.

    2nd, there was a study from the National Weight Control Registery comparing the BMR of obese individuals who lost weight to lean individuals of similiar weights who never lost weight. No significant difference between BMRs. Will sure later when I have my computer.

    3. What do you consider restrictive?Based on dietary recalls with obese individuals I have seen, dating an obese individual, and my obese friends I estimate some of them are eating 3,000+ calories a day, everyday. If they ate 2,000 calories a day they would lose weight and I do not find 2,000 restrictive. So I guess it depends on what people find restrictive.

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